Magne B6 ®

General characteristics. Structure:

Tablets, coated
Tablet kernel:
Active ingredients:
Lactate magnesium a dihydrate * - 470 mg
Pyridoxine a hydrochloride - 5 mg
Excipients: sucrose, kaolin heavy, acacias gum,
carboxypolymethylene 934, talc (magnesium hydrosilicate), magnesium stearate.
Tabletki:akation cover gum, sucrose, titanium dioxide, talc (magnesium
hydrosilicate), wax karnaubsky (powder).
* - 48 mg are equivalent to the content of magnesium (Mg ++)

Solution for intake
Active ingredients:
Lactate magnesium a dihydrate ** - 186,00 mg
Magnesium пидолат ** - 936,00 mg
Pyridoxine a hydrochloride - 10,00 mg
 Excipients: sodium disulphite, sodium saccharinate, fragrance
cherry and caramel, the water purified to 10 ml.
** - 100 mg are equivalent to the summary contents of magnesium (Mg ++)

Description. Tablets are coated: oval biconvex tablets, coated white color, with a smooth brilliant surface.
Solution for intake: transparent liquid of brown color with a caramel smell.

Pharmacological properties:

Pharmkodinamika. Magnesium is the vital element which is in all body tissues and is necessary for normal functioning of cells, participates in the majority of reactions of a metabolism. In particular, he participates in regulation of transfer of nervous impulses and in reduction of muscles. The organism receives magnesium together with food. The lack of magnesium of an organism can be observed at disturbance of a diet (diet) or at increase in need for magnesium (at the raised exercise and intellectual stress, a stress, pregnancy, use of diuretics). The pyridoxine (B6 vitamin) participates in many metabolic processes, in regulation of metabolism of a nervous system. B6 vitamin improves absorption of magnesium from digestive tract and its penetration into cells. Content of magnesium in serum:
- from 12 to 17 mg/l (0,5 - 0,7 mmol/l) speak about moderate insufficiency of magnesium.
- lower than 12 mg/l (0,5 mmol/l) speak about heavy deficit of magnesium.

Pharmacokinetics. Absorption of magnesium in digestive tract makes no more than 50% of the dose accepted inside. 99% of magnesium are in an organism in cells. About 2/3 intracellular magnesium are distributed in a bone tissue, and another 1/3 is in smooth and cross-striped muscular tissue. Magnesium preferential with urine is removed. With urine it is removed at least 1/3 from the accepted magnesium dose.

Indications to use:

The established deficit of magnesium isolated or connected with other scarce states which is followed by such symptoms as: acrimony, insignificant sleep disorders; gastrointestinal spasms or cardiopalmus; increased fatigue, pains and spasms of muscles, feeling of a pricking.

Route of administration and doses:

Before administration of drug it is necessary to consult with the doctor. Tablets are coated:
Adults are recommended to take 6-8 pill a day. To children 6 years (body weight more than 20 kg) are more senior than 4-6 tablets a day. Solution for intake.
Adults are recommended to accept 3-4 ampoules a day.
To children 1 years (body weight more than 10 kg) a daily dose are more senior makes 10-30 mg/kg and equals to 1-4 ampoules.
The daily dose should be divided into 2-3 receptions, to accept during food, washing down with a glass of water.
Solution in ampoules is dissolved in / a glass of water for reception by 2-3 times a day during food.
On average duration of treatment is 1 month.
Treatment should be stopped at once after normalization of level of magnesium in blood. ATTENTION:
The self-cracking ampoules with Magne of B6 do not demand use of a nail file. To open an ampoule, take it for a tip, previously having covered it with a piece of fabric, and break off it the sharp movement.

Features of use:

Information for patients with a diabetes mellitus: tablets, coated, contain sucrose as excipient.
In case of the accompanying deficit of calcium, deficit of magnesium has to be eliminated prior to introduction of additional reception of calcium.
At the frequent use of purgatives, alcohol, intense exercise and mental stresses the need for magnesium increases that can lead to development of deficit of magnesium in an organism.
Ampoules contain sulfite which can cause or worsen reactions of allergic type, including anaphylactic reactions, patients have risk groups.
Drug in a dosage form of a tablet is intended only for adults and children 6 years are aged more senior. For children of younger age drug in a dosage form solution for intake is recommended.

Influence on ability to drive the car and other mechanisms. Does not influence.

Side effects:

Allergic reactions to drug components. Frustration from digestive tract: abdominal pains, lock, nausea, vomiting, meteorism.

Interaction with other medicines:

- Simultaneous use of the drugs containing phosphates or salts of calcium can reduce considerably absorption of magnesium in digestive tract.
- Drugs of magnesium reduce tetracycline absorption, it is recommended to do an interval of 3 hours before Magne's use to B6.
- Magnesium weakens action of peroral thrombolytic means, reduces digestion of iron.
- B6 vitamin oppresses activity of the Levodopa.

Contraindications:

Hypersensitivity to drug components, the expressed renal failure (clearance of creatinine less than 30 ml/minute), a fenilketonuriya, children's age up to 6 years (for the tableted dosage form) and till 1 year (for solution), at intolerance of fructose, a syndrome of the broken absorption of glucose or a galactose or deficit of invertase-isomaltase. With care:
At moderate insufficiency of function of kidneys as there is a risk of development of a gipermagniyemiya.

Overdose:

At normal function of kidneys oral administration of magnesium does not cause toxic reactions. However, poisoning with magnesium can develop at a renal failure. Toxic effects generally depend on the content of magnesium in blood serum. Overdose symptoms: lowering of arterial pressure, nausea, vomiting, depression, delay of reflexes, distortion of results of the electrocardiogram, respiratory depression, coma, cardiac standstill and cardioplegia, anuretic syndrome.
Treatment: regidratation, artificial diuresis. At a renal failure the hemodialysis or peritoneal dialysis is necessary.

Storage conditions:

Period of validity. Tablets, coated: 2 years Solution for intake: 3 years
Drug cannot be used after expiry date. STORAGE CONDITIONS
Tablets, coated: in the dry, protected from light place at a temperature not above 25 °C.
Solution for intake: in the place protected from light at a temperature not above 25 °C.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Tablets, coated:
On 10 tablets in the blister from aluminum PVC/foil. On 5 blisters together with the application instruction place in a cardboard pack. Solution for intake:
On 10 ml of drug in the ampoules of dark glass (hydrolytic class III EF) soldered from two parties with the line of a break and drawing two marking rings on each of the parties. On 10 ampoules in a packaging insert from a cardboard together with the application instruction place in a cardboard pack.