Magne B6 ® forte

General characteristics. Structure:

Acting a veshchestva:magniya citrate - 618,43 mg that corresponds to 100 mg of magnesium (Mg ++), a pyridoxine a hydrochloride - 10 mg;
excipients: lactose, macrogoal-6000, magnesium stearate, gipromelloz 6 мПа.с, titanium dioxide (Е 171), talc.

Description. Oval biconvex tablets, film coated white color. On a break two layers are visible: cover of white color and tablet mass of white color.

Pharmacological properties:

Pharmacodynamics. Magnesium is the vital element which is necessary for normal functioning of cells, participates in the majority of reactions of a metabolism. In particular, he participates in regulation of transfer of nervous impulses and in reduction of muscles. 1/3 amounts of the magnesium which is contained in an organism collect in a bone tissue. The organism receives magnesium together with food. The lack of magnesium of an organism can be observed at disturbance of a diet (diet) or at increase in need for magnesium.
The pyridoxine (B6 vitamin) participates in many metabolic processes, promotes improvement of absorption of magnesium from digestive tract and to its penetration into cells.
Magnesium levels in serum:
- between 12 and 17 mg/l (1 - 1,4 ¼Ø¬ó/l or 0,5 - 0,7 mmol/l): point out moderate deficit of magnesium
- it is lower than 12 mg/l (1 ¼Ø¬ó/l or 0,5 mmol/l): point out heavy deficit of magnesium.

Pharmacokinetics. Gastrointestinal absorption of magnesian salts happens partially by the passive mechanism in which solubility of salt plays the defining role.
Extent of this absorption does not exceed 50%. Removal happens, preferential kidneys.

Indications to use:

The established deficit of magnesium isolated or connected with other scarce states which is followed by such symptoms as an acrimony, insignificant sleep disorders, gastrointestinal spasms, a cardiopalmus, increased fatigue, pains and spasms of muscles, feeling of a pricking in muscles.
If in a month of treatment there is no reduction of these symptoms continuation of treatment is inexpedient.

Route of administration and doses:

Pill should be taken entirely, washing down with a glass of water. Adults: 3-4 tablets the day divided into 2-3 receptions during food. Children are aged more senior than 6 years (weight about 20 kg):
10-30 mg/kg/days (0,4-1,2 mmol/kg/days), that is to children are more senior than 6 years (weight about 20 kg) 2-4 tablets the day divided into 2-3 receptions during food.
Read also here what tablets, more available at the price, it is possible to use instead of Magne B6 Forte. Usually treatment duration drugs of magnesium makes one month.

Features of use:

Tablets are intended only for adults and children 6 years are more senior.
At a moderate renal failure it is necessary to take drug with caution because of risk, development of a gipermagniyemiya.
At simultaneous deficit of calcium and magnesium, shortage of magnesium should be filled before additional reception of calcium.
At use of a pyridoxine in high doses for a long time (within several months or in certain cases - years) touch neuropathy which is followed by such symptoms as numbness and vestibular disturbances, a tremor of distal otel of extremities and gradually developing touch ataxy (a lack of coordination of movements) can develop. These disturbances usually are reversible and take place after cancellation of high doses of vitamin B.
Influence on ability to drive the car and other mechanisms
There are no special recommendations.

Side effects:

Allergic reactions, including skin; frustration from digestive tract: diarrhea, abdominal pains, lock, nausea, vomiting, meteorism.

Interaction with other medicines:

With a levodopa: activity a levodopa (if reception of this drug is not combined with reception of inhibitors of a peripheral dopa-decarboxylase) is inhibited by a pyridoxine. It is necessary to avoid any reception of a pyridoxine if along with a levodopa inhibitors of a peripheral dopa-decarboxylase are not appointed.
Not recommended combinations
Simultaneous use of the drugs containing phosphates or salts of calcium can reduce considerably absorption of magnesium in digestive tract. With phosphatic or calcic salts: these products oppress intestinal absorption of magnesium.
Combinations which should be taken into account. At appointment in tetracyclines it is necessary to observe an interval not less than three hours between intake of tetracycline and magnesium as magnesium reduces gastrointestinal absorption of tetracyclines.

Contraindications:

- Hypersensitivity to any of drug components.
- Heavy renal failure (clearance of creatinine less than 30 ml/min.).
- Fenilketonuriya
- Age up to 6 years (efficiency and safety are not established).
- A hereditary galactosemia, a sprue of glucose and a galactose or insufficiency of lactase (in connection with presence at composition of drug of lactose).
- A concomitant use of a levodopa (watch "Interactions with other medicines").
With care: moderate renal failure (danger of development of a gipermagniyemiya).
PREGNANCY AND PERIOD of BREASTFEEDING Pregnancy
During pregnancy drug is accepted only according to the recommendation of the doctor.
Breastfeeding period
In view of that magnesium gets into maternal milk, in need of administration of drug it is recommended to stop feeding by a breast.

Overdose:

At normal function of kidneys the overdose of magnesium at intake usually does not lead to emergence of toxic reactions. However in case of a renal failure development of poisoning with magnesium is possible.
Overdose symptoms which expressiveness depends on concentration of magnesium in blood: lowering of arterial pressure; nausea, vomiting; oppression of the central nervous system, decrease in reflexes; changes on the electrocardiogram (an urezheniye and/or disturbances of a heart rhythm); respiratory depression, coma, cardiac standstill and paralysis of breath; anury.
Treatment: regidratation, artificial diuresis. At a renal failure the hemodialysis or peritoneal dialysis is necessary.

Storage conditions:

To store at a temperature not above 30 °C. To store in the place, unavailable to children. Period of validity 2 years. Not to use drug after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets, film coated.
On 15 tablets in the blister from PVH-PE-PVDH/of aluminum foil.
On 2 or 4 blisters together with the application instruction in a cardboard pack.