Phenibutum

General characteristics. Structure:

Active ingredient: 250 mg of aminophenyl-butyric acid of a hydrochloride (Phenibutum) in 1 tablet.

Excipients: lactoses monohydrate, potato starch, povidone (polyvinylpirrolidone low-molecular medical), stearate calcium monohydrate.

Pharmacological properties:

Pharmacodynamics. Nootropic means, facilitates GAMK (at - aminobutyric acid) - the mediated peyoredacha of nervous impulses in the central nervous system (direct impact on GAMK-ergichesky receptors). Tranquilizing action is combined with aktiviruyuyoshchy effect. Also possesses antiagregantny, antioxidant and some protiyovosudorozhny action.

Improves a functional condition of a brain due to normalization of his metabolism and influence on a brain blood stream (increases volume and linear speed, reduces vascular resistance, improves microcirculation).

Does not influence on well-cared and adrenoceptors. Extends stage of latency and shortens duration and expressiveness of a nystagmus. Reduces vazovegetativny symptoms (including a headache, heavy feeling in the head, sleep disorders, irritability, emoyotsionalny lability). At course reception increases physical and intellectual effeciency (attention, memory, speed and accuracy of sensory-motor reactions). Reduces manifestations of an adynamy (improves health, increases interest and an initiative (motivation of activity)) without sedation or excitement.

Promotes decrease in feeling of alarm, tension and concern, normalizes a dream.

Does not cause oppression of the central nervous system in people of advanced age, the muscular weakening after-effect most often is absent. Reduces the oppressing influence of ethanol on the central nervous system.

Pharmacokinetics. Absorption is high, drug well gets into all body tissues and through a gematoyoentsefalichesky barrier (about 0,1% of the entered drug dose, and at persons of young and advanced age in much bigger degree get into tissues of a brain). It is evenly distributed in a liver and kidneys.

It is metabolized in a liver - 80-95%, metabolites pharmacological are inactive. Does not kumulirut. In 3 h it begins to be removed by kidneys, at the same time concentration in tissue of a brain does not decrease, and it is found in a brain in a teyocheniye of 6 h. About 5% are removed by kidneys in not changed look, partially removed with bile.

Indications to use:

- asthenic and alarming and neurotic states

- stutter, tics and enuresis at children

- sleeplessness and night alarm at people of advanced age

- Menyer's disease, dizzinesses connected with dysfunctions of a vestibular analizayotor of various genesis; prevention of a motion desease at kinetoza

- as a part of complex therapy at treatment of an alcoholic abstinence syndrome.

Route of administration and doses:

Inside after food 2-3 week courses. To adults and children from 14 years appoint 250-500 mg 3 times a day (the maximum daily dose of 1500 mg). To children from 8 to 14 years - on 250 mg 3 times a day. The single maximum dose at adults and children from 14 years makes 750 mg, at persons 60 years - 500 mg, from 8 to 14 years-250 of mg are more senior.

Stopping of an alcoholic abstinence syndrome in the first days of treatment: in the afternoon on 250 - 500 mg 3 times a day and for night of 750 mg, with gradual decrease in a daily dose to usual for adults.

Motion desease prevention: 250-500 mg once in 1 hour prior to the estimated beginning of rolling or at emergence of the first easy symptoms of a sea sickness. The antirocking to sleep action of Phenibutum amplifies at increase in a dose of drug. At approach of the expressed displays of seasickness (vomiting, etc.) purpose of Phenibutum inside mayoloeffektivno even in doses of 750-1000 mg.

Otogenic labyrinthitis and Menyer's disease in the period of an aggravation: 750 mg 3-4 times a day within 5-7 days, at decrease in expressiveness of vestibular frustration - on 250-500 mg 3 times a day within 5-7 days and then - on 250 mg of 1 times a day within 5 days. At the easy course of diseases - on 250 mg 2 times a day within 5-7 days, with a poyosleduyushchy dose decline to 250 mg of 1 times a day within 7-10 days.

Asthenic states: inside, on 40-80 mg/days, in some cases - to 200-300 mg/days within 1-1,5 months.

Depressions of late age - 2-3 times a day on 40-200 mg/days within 1,5-3 months.

Features of use:

At prolonged use it is necessary to control indicators of function of a liver and peripheral blood.

Influence on ability to manage vehicles and mechanisms. It is necessary to abstain from potentially dangerous types of a deyayotelnost requiring special attention.

Side effects:

Irritability strengthening, excitement, uneasiness, dizziness, headache, drowsiness, nausea (at the first receptions), allergic reactions (skin rash, an itch).

Interaction with other medicines:

Extends and strengthens action of somnolent, narcotic analgetics, neuroleptics, protivoparkinsonichesky and antiepileptic means.

Contraindications:

Hypersensitivity, children's age up to 8 years. Patients with rare hereditary diseases, such as a lactose intolerance, deficit of lactase or glyukozo-galaktozny malabsorption should not accept drug (in connection with existence in a lactose sostayova).

With care at erosive cankers of digestive tract, a liver failure, pregnancy, in the period of a lactation.

Overdose:

Symptoms: the expressed drowsiness, nausea, vomiting, fatty dystrophy of a liver (reception more than 7000 mg), an eosinophilia, a lowering of arterial pressure, a renal failure.

Treatment: gastric lavage, reception of absorbent carbon and performing simptomaticheyosky therapy.

Storage conditions:

In the place protected from light at a temperature not above 25 °C. To store in the places unavailable to children. A period of validity - 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets on 250 mg. Packaging: on 10 tablets in a blister strip packaging. On 2, 3 or 5 blister strip packagings with the application instruction place in a pack from a cardboard.