Tolperil-Zdorovye, solution for infection on 1 ml No. 5

General characteristics. Structure:

International and chemical name: tolperilsostav: Tolperisonum a lidocaine hydrochloride a hydrochloride of 1 ml hydrochloride Tolperisonum (in terms of 100% substance) 100 mg of lidocaine of a hydrochloride (in terms of 100% substance) 2,5 mg; Excipients: diethylene glycol monoyetilovy ether, methylparahydroxybenzoate (E218), water for injections. Main physical and chemical properties: the transparent, colourless or slightly painted solution.

Pharmacological properties:

Pharmacological Muscle relaxant of the central action. The mechanism of action is caused by braking of conductivity of impulses of primary afferent fibers and motor neurons that leads to blocking of spinal mono-and polisinaptichesky reflexes. By braking of receipt of Sa 2 + in synapses for the second time interferes with an exit of mediators. Slows down carrying out excitement in the retikulospinalny way. Strengthens a peripheral blood stream irrespective of influence of the central nervous system. In development of this effect the effect of Tolperisonum can play a role weak spasmolytic and Anti-adrenergic.

Pharmacokinetics. Bioavailability owing to the expressed metabolism makes about 20%. It is metabolized in a liver and kidneys. The elimination half-life after intravenous administration makes about 1,5 hours. It is excreted by kidneys, it is preferential (more than 99%) in the form of metabolites.

Indications to use:

The tone and spasms of cross-striped muscles owing to organic lesions of the central nervous system is patholologically strengthened (including defeats of pyramidal ways, multiple sclerosis, a stroke, a myelipathy, encephalomyelitis); the raised tone of muscles, a spasm of muscles, muscular contractures at musculoskeletal system diseases (a spondylosis, a spondylarthrosis, cervical and lumbar syndromes, arthroses of large joints); recovery treatment after orthopedic and traumatologic operations. The diseases which are followed by a spasm of arteries and disturbance of an innervation of vessels (for example, a Crocq's disease, Sharko's syndrome).

Route of administration and doses:

The drug is administered intramusculary on 1 ml by 2 times a day or slowly intravenously on 1 ml of 1 times a day.

Features of use:

Considering existence in lidocaine drug before use surely it is necessary to carry out a sensitivity test to lidocaine.

Ability to influence speed of response at control of motor transport or other mechanisms. At control of motor transport or other mechanisms it is necessary to consider a possibility of emergence of such side reactions as arterial hypotension and muscular weakness.

Use of drug during pregnancy is contraindicated. In need of use of drug in the period of a lactation feeding by a breast needs to be stopped.

Children. Injection solution cannot be applied at children's age.

Side effects:

From TsNS: muscular weakness, headache. From the alimentary system: nausea, vomiting, a sensation of discomfort in a stomach.
From cardiovascular system: arterial hypotension.
Allergic reactions: in some cases - a skin itch, an erythema, a small tortoiseshell, a Quincke's disease, an acute anaphylaxis.

Interaction with other medicines:

Drug strengthens action of a niflyuminovoa of acid therefore at simultaneous use the acid niflyuminovoa dose decline is necessary.
Tolperisonum does not show sedation therefore it can be applied in a combination with sedative, somnolent, tranquilizing means. Does not strengthen effect of alcohol on the central nervous system.
Use during pregnancy or feeding by a breast.

Contraindications:

Hypersensitivity to drug components, a heavy myasthenia, pregnancy and the period of feeding by a breast, children's age.

Overdose:

There are no data on symptoms of overdose.
Treatment: drug withdrawal, symptomatic treatment. Specific антидо

Storage conditions:

To store in original packaging at a temperature from 2 °C - 8 °C. To store in the place, unavailable to children.

Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

Solution for injections in ampoules on 1 ml No. 5 in a box, No. 5 or No. 5х2 in the blister, in a box.