Целлекс

General characteristics. Structure:

Active ingredient: 2,4 mg of polypeptides from a brain of embryos of pigs, in terms of crude protein 0,9 (at the nominal content of crude protein of 1,65 mg on 1 ml of substance).  

Excipients: glycine, 0,1M of hydrophosphate dinatrium solution to рН 7,8, sodium of chloride, polysorbate-80, the water purified.

Complex of the proteins and polypeptides of embryonal brain fabric with a molecular weight from 5 to 200 kd representing growth factors, differentiations and alarm molecules. Solution for parenteral administration. Drug is used for treatment of acute disorders of cerebral circulation of ischemic and hemorrhagic character in an acute and early rehabilitation stage of a disease.

Pharmacological properties:

Pharmacodynamics. Availability of tkanespetsifichesky alarm proteins and polypeptides - growth factors, factors of a differentiation of nervous cells in drug causes its direct neuroreparative action, due to regulation of concentration of a pool of neurotransmitters, with braking of a spilover of exciting amino acids.

Drug activates secondary neuroprotection due to stimulation of processes of a sinaptogenez, recovery of signals of an autophagy, improvement of fabric immunoregulation with braking of immunogene cytotoxicity of macrophages. At the same time it is noted

tkanespetsifichesky and systemic reparative action of drug with recovery of regenerative and reparative potential of cells of a brain, reduction of number of the damaged cells and expressiveness of perifocal hypostasis in a penumbra zone (allows to achieve considerable restriction of the center of a necrosis of brain fabric) with recovery of microcirculation and the general perfusion.

Recovery and regulatory stimulation of various kompartment of TsNS with system influence of growth factors, a differentiation and alarm molecules provides decrease in terms of recovery and rehabilitation of patients with damages of the central and peripheral nervous system of vascular genesis and recovery of motive, sensitive and cognitive functions. 

The therapeutic effect usually develops in 3-5 days after the beginning of administration of drug.

Pharmacokinetics. The complex structure of Tselleksa® which active fraction consists of the balanced and stable mix of biologically active proteins and polypeptides possessing total multifunctional action does not allow to carry out the usual pharmacokinetic analysis of separate components.

Indications to use:

Cerebrovascular diseases:

- acute disorders of cerebral circulation in the acute and early rehabilitation period of a course of a disease as a part of complex therapy.

Route of administration and doses:

The adult drug appoint in a dose 0,1 - 0,2 mg of 1 times a day subcutaneously within 10 days depending on weight of a condition of the patient. If necessary conduct a repeated course in 10 days. Researches on use of drug in children's practice were not conducted.

Features of use:

It is necessary to appoint with care drug in the presence in the anamnesis of allergic reactions to drugs of the proteinaceous and peptide nature.

Lack of the corresponding researches does not allow to use drug at this contingent of patients.

Now there are no data on influence ^{of the drug Tselleks®} on ability to driving and work with the mechanisms requiring special attention and speed of mental and motor reactions.

With extra care it is appointed at arterial hypertension of a malignant current in a decompensation stage; sympathoadrenal crises as the panic attacks; the expressed alarming and depressive frustration.

Drug does not contain prion infections and viruses.

Side effects:

Allergic reactions in the form of not expressed hyperemia in an injection site, hypersensitivity reactions (skin rash, an itch, a Quincke's disease), subfebrile condition, a sleep disorder, a headache can be noted.

Interaction with other medicines:

At combined use with psychogogic drugs and alcohol perhaps psychomotor excitement, sleep disorders.

Reduction of activity of anesthetics, tranquilizers, neuroleptics is possible.

Contraindications:

Epilepsy, maniacal psychosis, productive nonsense, delirium, age up to 18 years (in connection with insufficiency of clinical data).

Overdose:

Now cases of overdose ^{of the drug Tselleks®} are noted.

Storage conditions:

In the place protected from light, at ^{a temperature from 2 ° C to 8 ° C}. To store in the place, unavailable to children. Period of validity 1 year.

Issue conditions:

According to the recipe

Packaging:

Solution for hypodermic introduction of 0,1 mg/ml.

On 1 ml or 2 ml in ampoules of dark glass with a capacity of 1 ml or 2 ml the import, having a ring tension for opening, or the ampoules having a break point.

On 1 ampoule on 1 ml in a blister strip packaging from a film polyvinyl chloride.

On 1 ampoule on 2 ml in a blister strip packaging from a film polyvinyl chloride.

On 2 ampoules on 1 ml in a blister strip packaging from a film polyvinyl chloride.

On 2 ampoules on 2 ml in a blister strip packaging from a film polyvinyl chloride.

On 5 ampoules on 1 ml in a blister strip packaging from a film polyvinyl chloride.

On 5 ampoules on 2 ml in a blister strip packaging from a film polyvinyl chloride.

1 or 2 blister strip packagings together with the application instruction place in a pack cardboard.