Betagis

General characteristics. Structure:

Active agent: betagistina dihydrochloride of 16 mg.

Pharmacological properties:

Pharmacodynamics. Betagistin — a synthetic analog of a histamine. Drug activates organ microcirculation, in particular, increases a blood stream in an inner ear and in basilar arteries. At stabilization of a labyrinth blood-groove there is a normalization of endolymphatic pressure both in a labyrinth, and in the cochlear device of an inner ear owing to what the subjective feeling of dizziness decreases. Drug stops bad attacks of vestibular dizziness of various etiology, eliminates cochlear disturbances, noise and a ring in ears, prevents development of deafness. The preventive and therapeutic effectiveness of system use of a betagistin is shown at Menyer's disease to which main clinical symptoms the dizziness attacks (вертиго) which are followed by nausea and vomiting belong; sonitus; the progressing relative deafness. The best results noted at purpose of drug at initial stages of a disease of Menyer.
Betagistin suppresses diaminoxidase, blocking disintegration of an endogenous histamine, and stimulates H1 receptors of an inner ear. Influence on precapillary sphincters and increase in a precapillary blood-groove in a labyrinth and a curl are result.
Betagistin has the expressed central effect. Blocking H3 receptors, drug normalizes neyronalny transmission in polisinaptichesky neurons of side kernels of a vestibular nerve at the level of the bridge of a trunk part of a brain.
Though бетагистин is histamine-like substance, it does not cause disturbances of permeability of capillaries, changes of the system ABP, does not influence a tone of unstriated muscles of internals and secretion of a gastric juice.

Pharmacokinetics. At intake бетагистин it is quickly absorbed in a GIT. Bioavailability of drug reaches 100%. Cmax of a betagistin in a blood plasma is defined by 2 h after use.
At primary passing through a liver of a betagistin dihydrochloride is metabolized to 2-piridilouksusny acid. From an organism it is allocated with kidneys. T1/2 is 3–4 h. Completely drug is removed in 24 h after use.

Indications to use:

• disease and Menyer's syndrome;
• dizziness of various genesis (at osteochondrosis of cervical department of a backbone, vertebro-basilar insufficiency, atherosclerosis of vessels of a brain, after a craniocereberal injury, surgeries, psychotic genesis, idiopathic вертиго).

Route of administration and doses:

Betagis accept inside in time or after food. The dose of drug and duration of a course of treatment are defined individually for each patient depending on indications and disease severity.
At course treatment appoint adult 24–48 mg of a betagistin a day (on 1/2–1 tablet 3 times a day).
In most cases improvement of a state is noted in 2–3 weeks, if necessary the course of treatment Betagis can be prolonged up to several months.

Features of use:

With extra care appoint drug to patients with OH, and also the patient with stomach ulcer and/or a duodenum in the anamnesis.
Betagis along with antihistaminic drugs is not recommended to appoint.
Children
Betagis's use for children aged up to 12 years is not recommended as for patients of this age group did not define safety and efficiency of drug.
Period of pregnancy and feeding by a breast
During pregnancy and feeding by a breast Betagis's use is allowed strictly according to indications and under direct control of the doctor only when the expected advantage exceeds possible risk.
Ability to influence speed of response at control of vehicles and work with other mechanisms
Betagis has no sedative effect and does not influence ability of the patient to activity which requires special attention and speed of psychomotor reactions.

Side effects:

From a GIT: a sensation of discomfort in epigastric area, nausea, vomiting (it is frequent — at patients with chronic gastrointestinal diseases).
From a nervous system: very seldom — a headache.
Allergic reactions: very seldom — rash on skin, a hyperemia and an itch of integuments.

Interaction with other medicines:

At simultaneous use with antihistaminic drugs Betagis's efficiency decreases.

Contraindications:

the increased individual sensitivity to a betagistin or other components of drug, stomach ulcer and/or a duodenum in an aggravation phase, a pheochromocytoma, OH with frequent attacks. Children's age up to 12 years.

Overdose:

Symptoms: nausea, vomiting, pain in epigastric area, a headache, drowsiness, increase in the ABP, in hard cases — spasms.
Treatment: it is artificial to cause vomiting or to wash out a stomach. There is no specific antidote. Symptomatic treatment.

Storage conditions:

At a temperature of 15-25 °C.

Issue conditions:

According to the recipe

Packaging:

Tab. of 16 mg контурн. ячейк. unitary enterprise., No. 10, No. 30, No. 90.