Strezam

General characteristics. Structure:

Active agents:

Etifoksina hydrochloride                          of 50 mg 
Lactoses monohydrate                                of 119 mg 
Talc                                                      of 15 mg 
Cellulose of microcrystallic            10 mg 
Silicon dioxide of colloid anhydrous    3 mg 
Magnesium stearate                                          of 3 mg 

Structure of a cover of the capsule:
titanium
dioxide
gelatin
indigo carmine.

Pharmacological properties:

Derivative benzoxazine, has anxiolytic activity, to a lesser extent has sedative effect. Does not cause accustoming and a withdrawal. Selectively influences SG channels (chloric channels) supramolecular GAMK-benzodiazepin-hlorionofor a receptor complex, inhibiting GABA-ergic transfer.

Pharmacokinetics. It is quickly soaked up from a GIT, quickly metabolized in a liver before formation of several metabolites. One of metabolites (диэтилэтифоксин) is active and its elimination half-life makes about 20 hours. Gets through a placental barrier.
Time of achievement of the maximum concentration in blood - 2-3 hours, an elimination half-life - about 6 hours.
It is removed preferential with urine in the form of metabolites, and also in not changed look in small amounts. Also it is removed with bile.

Indications to use:

It is applied to elimination of alarm, fear, internal tension, an acrimony, decrease in mood, including against the background of somatopathies, especially cardiovascular nature.

Route of administration and doses:

Inside, with a small amount of water.
The dose of drug is defined by the doctor, individually, depending on a condition of the patient.
About 1 capsule 3 times a day, or on 2 capsules 2 times a day is usually appointed. (150-200 mg/days)
Treatment duration - from several days to 4-6 weeks, depending on a condition of the patient.

Features of use:

Because of presence at composition of drug of lactose, drug should not be used at a galactosemia, a sprue of glucose and a galactose, and also in case of a lactose intolerance.
In case of the admission of administration of drug it is not necessary to double a dose at the following reception.
Due to the risk of emergence of drowsiness, it is necessary to avoid during treatment control of motor transport and the activity requiring special attention, for example, of control of various mechanisms.

Side effects:

The insignificant drowsiness appearing in the first days of reception and usually disappearing independently in the course of treatment; skin rashes, and also allergic reactions in the form of a small tortoiseshell and a Quincke's edema are seldom possible.

Interaction with other medicines:

Exponentiates effect of drugs, the oppressing TsNS, such as opioid analgetics, barbiturates, somnolent drugs, antihistamines, neuroleptics, etc. Also strengthens alcohol influence.

Contraindications:

Depressed cases, myasthenia, heavy disturbances of functions of a liver and/or kidneys, hypersensitivity. It is not recommended to use aged up to 18 years.

Use of drug at pregnancy and a lactation: it is not recommended to use drug during pregnancy. At detection of pregnancy during administration of drug, it is necessary to consult with the doctor concerning treatment continuation. It is not recommended to use drug when feeding by a breast.

Overdose:

Symptoms: slackness, excessive drowsiness.

Treatment: gastric lavage large amount of water, symptomatic treatment. The specific antidote is absent.

Storage conditions:

At a temperature from 15 °C to 25 °C. To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

Capsules; on 12 capsules in blisters PVC/aluminium, on 2 blisters with the application instruction in packs cardboard; or on 20 capsules in blisters PVC/aluminium, on 3 blisters with the application instruction in packs cardboard.