Diagiperon

General characteristics. Structure:

Active ingredient: spirit extraction from a grass of a St. John's Wort 1:5. Not less than 0,0075 mg of giperitsin, not less than 0,3 mg of flavonoids in 1 ml of medicine.

Supportive applications: ethanol.

The vegetable medicine improving a functional condition of the central and vegetative nervous systems.

Pharmacological properties:

Pharmacodynamics. Medicine of a plant origin. Renders anxiolytic (removes alarm, stress) and antidepressive action (increases mood). Improves a functional state central and the autonomic nervous system.

Diagiperon contains not less than 10 biochemical active agents having antidepressant properties from which have the greatest activity гиперецин and псевдогиперецин. The antidepressive effect of giperetsid is based on suppression of the return capture of neurotransmitters, such as: serotonin, noradrenaline, dopamine, GAMK.

Besides, Diagiperon possesses antiinflammatory action.

Pharmacokinetics. The maximum concentration after a single dose of medicine is reached in 4,5 hours for a giperitsin and 1,5 hours of a psevdogiperitsin. The elimination half-life makes 24,8 hours for a giperitsin and 16,3 hours for a psevdogiperitsin.

Indications to use:

Soft and moderate depressive frustration (condition of concern, sleep disorder, decrease in mood, apathy, etc.).

For a symptomatic treatment of easy manifestations of gastrointestinal discomfort (functional dyspepsias).

Locally for treatment of minor injuries, grazes, inflammations of skin, disinfection of wounds.

Prevention and treatment of tonsillitis, quinsy, ulites and stomatitises.

In complex therapy. At dyskinesia of bilious ways, застоях bile in a gall bladder, cholecystitis, an urolithiasis, decrease in filtrational ability of kidneys.

Route of administration and doses:

Inside till 20-30 drops before food 3 times a day within 14-30 days.

Locally, for rinsings – till 30-40 drops on a half-glass of water.

Features of use:

Prescription of medicine is not recommended to children up to 12 years.

Due to the lack of sufficient clinical data, it is not recommended to use during pregnancy and the lactation period.

It is impossible to use after processing of a wound surface solutions of iodine, potassium of permanganate, hydrogen peroxide which cause an inactivation of biologically active components of medicine.

Emergence of an insignificant deposit does not exert impact on efficiency of medicine.

Side effects:

Dispeptic frustration, allergic reactions, the increased photosensitivity, especially at persons with light skin, fatigue, concern, confusion of consciousness.

Interaction with other medicines:

Medicine should not be used along with other antidepressants.

At a concomitant use with cyclosporine, indinaviry, protease inhibitors, indirect anticoagulants (фенпрокумон, warfarin), digoxin, theophylline amitriptyline, nortriptilliny easing of effect is possible. Reception with MAO inhibitors is not recommended. The interval between reception of the specified medicines has to be not less than 14 days.

The concomitant use with the photosensitizing means leads to strengthening of a photosensitization.

Contraindications:

Endogenous depressions, photosensitization, individual hypersensitivity to medicine.

Overdose:

Strengthening of by-effects is possible.

Storage conditions:

To store in the place protected from light at a temperature not above 20 °C. To store in the place, unavailable to children. A period of validity – 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

30 ml in bottles in packaging No. 1.

50 ml in bottles in packaging No. 1.