Секразол®

General characteristics. Structure:

Active ingredient: 30 mg of Ambroxol hydrochloride.

Excipients: sorbitol of 70%, methylparahydroxybenzoate, пропилпарагидроскибензоат, sodium citrate, citric acid monohydrate, crimson fragrance, the water purified.

Expectorant.

Pharmacological properties:

Pharmacodynamics. СЕКРАЗОЛ® is Mucolyticum and expectorant substance which renders the liquefying effect on a secret of respiratory tract. Reduces viscosity of a mucous secret that promotes improvement of function of a tsiliarny epithelium, promotes removal of a secret and facilitates breath.

Secretory activity of respiratory tract is normalized at use of Sekrazol® of syrup and the natural epithelial layer is recovered.

Pharmacokinetics. At oral administration Ambroxol is well soaked up from digestive tract; at reception to food, the maximum concentration in a blood plasma is observed in 2 hours. Bioavailability of Ambroxol about 60%. About 30% of Ambroxol are metabolized in a liver.

The period of elimination makes about 22 hours. Effective concentration in plasma> 30 ng/ml is observed at reception of a dose of 30 mg twice a day. In this state constant minimum concentration makes 50 ng/ml, the doubled doses of Ambroxol do not influence cumulation in plasma. Ambroxol is removed with urine in the form inactivated, connected with glucuronides.

Indications to use:

- the acute and chronic respiratory diseases which are followed by allocation of a viscous phlegm;

- chronic bronchitis with a bronkho-obstructive syndrome;

- bronchial asthma;

- bronchoectatic disease;

- pneumonia.

Route of administration and doses:

Children. To children up to 2 years about ¼ teaspoons twice a day are appointed (1,25 ml =7,5 mg of Ambroxol)

Children are 2-5 years old on ¼ - ½ teaspoons 3 times a day (1,25 – 2,5 ml = 7,5 – 15 mg of Ambroxol)

To children of 5 - 12 years on ½ – 1 teaspoon twice a day (2,5 – 5 ml = 15 – 30 mg of Ambroxol)

Adults. The usual recommended initial dosage in the first 2 – 3 days -

2 teaspoons (10 ml = 60 mg of Ambroxol) 3 times a day. After that 1 teaspoon (5 ml = 30 mg) 3 times a day or 2 teaspoons (10 ml = 60 mg) 2 times a day is appointed.

The optimum duration of therapy is 8 – 10 days. Syrup is accepted inside after food, washing down with enough warm liquid (water).

Features of use:

It is necessary to be careful at appointment to patients with a renal or liver failure.

Pregnancy and period of a lactation. In the first trimester of pregnancy it is not necessary to appoint Ambroxol. In the second and third period of pregnancy it is necessary to estimate potential advantage of therapy for mother and possible risk for a fruit.

Features of influence of medicine on ability to manage the vehicle or potentially dangerous mechanisms. Does not exert impact on ability to manage the vehicle.

Side effects:

Seldom:

- nausea, vomiting, diarrhea;

- headache, fatigue, weakness;

- itch;

- passing increase in hepatic transaminases in blood (NUCLEAR HEATING PLANT, ALT).

Interaction with other medicines:

Combined use of Sekrazol® with:

- the atropine and other drugs having anticholinergic effects, such as амантадин, tricyclic antidepressants, a haloperidol, blockers histamine H1 of receptors, and procaineamide, excepting ипратропиум, suppressing activity of a ciliate epithelium and reducing mukotsiliarny clearance, can lead to accumulation of a secret

- the raised doses of antibechic drugs, leads to suppression of a tussive reflex, therefore, removal of the bronchial secret which is formed in bigger quantity under the influence of Ambroxol is at a loss.

It is not recommended to apply Sekrazol® with codeine or other antibechic drugs containing codeine.

Contraindications:

- hypersensitivity to Bromhexine or its metabolite to Ambroxol in the anamnesis;

- peptic ulcer of a stomach and duodenum;

- convulsive syndromes of various etiology;

- first trimester of pregnancy and period of a lactation.

Overdose:

Symptoms: strengthening of side effects.

Treatment: a gastric lavage by means of induction of vomiting with ipecacuanha syrup; at spasms, coma or in the absence of an emetic reflex lavage with use of the nazogastralny probe is shown. Symptomatic therapy. There is no specific antidote.

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children! Period of storage 3 years. Not to apply after a period of storage. A period of storage after the first opening of packaging of 6 months.

Issue conditions:

According to the recipe

Packaging:

On 150 ml in bottles from dark glass with the screwing-up cover and control of the first opening.

On 1 bottle together with a measured spoon and the instruction on a medical use in the state and Russian languages place in a pack from a cardboard with the hologram of manufacturing firm.