Виферон®

General characteristics. Structure:

Active ingredient: 36 000 ME of interferon alpha 2b human recombinant.

Excipients: alpha tocopherol acetate, the benzoic acid, sodium pyroborate decahydrate, methionine, citric acid monohydrate, sodium the chloride, solution of albumine of serumal human 10%, glycerin distilled (глицерол), a karmelloza of sodium ethanol of 95%, the water purified.

Pharmacological properties:

Pharmacodynamics. Interferon alpha 2b human recombinant has immunomodulatory, antiviral and anti-proliferative properties. Suppresses RNA replication - and the DNA-containing viruses. Immunomodulatory properties of interferon, such as strengthening of phagocytal activity of macrophages, increase in specific cytotoxicity of lymphocytes to target cells cause its mediated antibacterial activity.

In presence of antioxidants of alpha tocopherol of acetate, lemon and benzoic acids specific antiviral activity of interferon increases, its immunomodulatory action amplifies that allows to increase efficiency of own immune response of an organism on causative agents of infections.

Drug possesses the expressed local immunomodulatory action and promotes increase in locally formed antibodies of a class of the secretory IgA interfering fixing and reproduction of pathogenic microorganisms on mucous membranes that provides preventive effect of drug for prevention of viral and other diseases.

The gel basis provides the prolonged effect of drug. The antioxidants which are a part of a dosage form – alpha tocopherol acetate, lemon and benzoic acids possess antiinflammatory, membrane stabilizing, regenerating properties, and also promote preservation of biological activity of interferon alpha 2b human recombinant.

Indications to use:

- in complex therapy of a SARS, including flu, the frequent and long SARS including complicated by a bacterial infection;
- prevention of a SARS, including flu;
- in complex therapy of the recurrent stenosing laryngotracheobronchitis;
- prevention of the recurrent stenosing laryngotracheobronchitis;
- in complex therapy acute and aggravations of a persistent recurrent herpes infection of skin and mucous, including an urogenital form of a herpes infection;
- in complex therapy of a herpetic cervicitis.

Route of administration and doses:

Drug is used outwardly and locally.

In complex therapy of a SARS, including flu, the long and frequent SARS including complicated by a bacterial infection.

Patients	Dosing mode	Course duration
Children, adult, pregnant	the strip of gel no more than 0,5 cm long is applied on previously dried mucosal surface of a cover of a nose and/or on a surface palatal mindalin3-5 once a day	5 days, if necessary a course can be prolonged.

The recurrent stenosing laryngotracheobronchitis.

Patients	Dosing mode	Course duration
Children, adult, pregnant	the strip of gel no more than 0,5 cm long is applied on a surface of palatine tonsils in the acute period of a disease of 5 times a day	5-7 days
	the strip of gel no more than 0,5 cm long is applied on a surface of palatine tonsils after the acute period by 3 times a day	3 weeks

Acute and persistent recurrent herpes infection (at emergence of the first symptoms of a disease or in the period of harbingers).

 

Patients	Dosing mode	Course duration
Children, adult, pregnant	the strip of gel no more than 0,5 cm long is applied by means of the pallet or a wadded tampon / wadding stick on previously dried struck surface of 3-5 times a day	5-6 days. If necessary duration of a course is increased before disappearance of clinical manifestations.

Herpetic cervicitis.

 

Patients	Dosing mode	Course duration
Children, adult, pregnant	1 ml of gel apply with a cotton plug on the surface of a neck of uterus which is previously cleared of slime 2 times a day	7 days. If necessary duration of a course can be increased up to 14 days.

SARS, including flu.

 

Patients	Dosing mode	Course duration
Children, adult, pregnant	during rise in incidence the strip of gel no more than 0,5 cm long is applied on previously dried mucosal surface of a cover of a nose and/or on a surface of palatine tonsils by 2 times a day	2-4 weeks

The recurrent stenosing laryngotracheobronchitis.

 

Patients	Dosing mode	Course duration
Children, adult, pregnant	the strip of gel no more than 0,5 cm long is applied on a surface of palatine tonsils by means of the pallet or a wadded tampon / a wadding stick by 2 times a day	3-4 weeks, courses repeat 2 times a year

 

Features of use:

On a mucous membrane of a nasal cavity gel is applied after clarification of nasal passes, on a surface of palatine tonsils – in 30 min. after acceptance of food. When putting gel on palatine tonsils not to touch almonds with a cotton plug, and only gel, gel at the same time independently flows down down an almond surface. When putting gel on a neck of uterus it is necessary to remove previously with a cotton or gauze plug slime and allocations from vaults of the vagina and a neck of uterus.

When putting gel on affected areas of skin and mucous membranes in 30-40 min. the pellicle on which apply drug again is formed. At desire, a film it is possible exfoliate or to wash away water before repeated putting drug.

Use at pregnancy and in the period of a lactation. Pregnancy and a lactation are not a contraindication for use of drug owing to very low absorption of components. In the period of a lactation not to apply on area of nipples and an areola.

Side effects:

Development of allergic reactions (skin rashes, itch) is in rare instances possible.

Interaction with other medicines:

Drug is well combined with all medicines used at treatment of the above-stated diseases (antibiotics, himiopreparata, glucocorticosteroids).

Contraindications:

Hypersensitivity to any of drug components.

Overdose:

 

Storage conditions:

Storage at a temperature from 2 to 8 ºС. To store in the place, unavailable to children. A period of validity - 1 year. Not to use after a period of validity.

Issue conditions:

Without recipe

Packaging:

Gel for external and topical administration, 36000 ME/g. On 12,0 g in tubas aluminum. 1 tuba with the Application instruction in a pack from a cardboard.