Gepatrombin

General characteristics. Structure:

Active agent: heparin sodium of 30 000 ME; cordianine of 250 mg; декспантенол 250 mg

Excipients: carbomer - 933 mg, left menthol - 20 mg, dinatrium эдетат - 100 mg, троламин - 550 mg, oil of needles of a mountain pine - 80 mg, oil of needles of a pine ordinary - 80 mg, lemon oil - 20 mg, sorbitol - 2 g, isopropanol - 25.37 g, софтиген 767 (macrogoal-6-glitserilkaprilokaprat) - 200 mg, polysorbate - 500 mg, the water purified - 68.485 ml.

Active agent: heparin sodium of 50 000 ME; cordianine of 250 mg; декспантенол 250 mg

Excipients: carbomer of 940 - 1.1, left menthol - 20 mg, dinatrium эдетат - 100 mg, trietanolamine - 590 mg, oil of a pine of ordinary (Pini silvestris) - 80 mg, oil of a cedar elfin woodland (Pini pumilionis) - 80 mg, essential oil of a lemon - 20 mg, sorbitol of 70% (uncrystallizable) - 2 g, isopropanol - 25.37 g, софтиген 767 - 200 mg, polysorbate of 80 - 1 g, the water purified - 68.86 ml.

Pharmacological properties:

The combined drug with the antitrombotichesky, antiinflammatory and improving an angenesis action for external use.
Heparin - anticoagulant of direct action. At topical administration heparin interferes with formation of blood clots, possesses antiedematous and antiinflammatory action, improves a local blood stream.
Cordianine renders antiinflammatory action, stimulates processes of a metabolism in fabrics and promotes proliferation of cells.
Dekspantenol improves heparin absorption, stimulates granulation and epithelization of fabrics.

Pharmacokinetics. After local drawing on skin heparin rather quickly gets through epidermis and collects in upper layers of skin. Actively contacts skin proteins. From fabrics about 1 h is allocated slowly with the allocation period. Also 0.6 ME/ml respectively in skin have pharmacological effect in concentration from 10 ME/ml in epidermis.

Indications to use:

— thrombosis;
— thrombophlebitis;
— varicosity;
— sports injuries;
— tendovaginitis;
— inflammatory infiltrates.

Route of administration and doses:

Gel is applied on skin with a thin layer, rubbing the easy massing movements from below up. In a case of use of gel at thromboses and thrombophlebitises massaging is not recommended.

Features of use:

The essential oils which are a part of other ingredients of gel have antimicrobic and analgeziruyushchy effect.

Side effects:

Allergic reactions: skin rash, dermahemia, small tortoiseshell, Quincke's disease.

Interaction with other medicines:

Data on medicinal interaction of drug Gepatrombin are not provided.

Contraindications:

— the infected defeats of integuments;
— disturbance of integrity of integuments (for gel);
— hypersensitivity to drug components.

Use of drug GEPATROMBIN at pregnancy and feeding by a breast
Use at pregnancy and in the period of a lactation (breastfeeding) of Gepatrombin with the content of heparin sodium 300 ED/1 of is possible in cases when the expected advantage of therapy for mother exceeds potential risk for a fruit or the baby.

Data on a possibility of use of Gepatrombin with the content of heparin sodium 500 ED/1 of at pregnancy and in the period of a lactation are not provided.

Overdose:

Data on drug overdose Gepatrombin are not provided.

Storage conditions:

Drug should be stored in the place, unavailable to children, at a temperature from 15 °C to 25 °C.

Issue conditions:

Without recipe

Packaging:

Gel for наружн. comment of 300 ME +2.5 mg +2.5 mg / 1: 40 g of a tube.

Gel for наружн. comment of 500 ME +2.5 mg +2.5 mg / 1: 40 g of a tube.