Агриппин®

General characteristics. Structure:

Active ingredients: 250 mg of paracetamol, 50 mg of calcium of a gluconate, 15 mg of ascorbic acid, 10 mg of a difengidramin of a hydrochloride, 10 mg of Rutinum.

Excipients: starch, aerosil, calcium stearate.

Analgetic antipyretic of the combined structure.

Pharmacological properties:

Pharmacodynamics. Paracetamol has febrifugal, analgeziruyushchy and antiinflammatory effect. The mechanism of action is caused by oppression of synthesis of prostaglandins due to blocking of enzyme of cyclooxygenase and influence on the center of thermal control in a hypothalamus.

Ascorbic acid participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis. Promotes increase in body resistance.

Difengidramin - a blocker histamine H1 receptors, has antiallergic, antiedematous, mestnoanesteziruyushchy effect (reduces permeability of vessels, eliminates puffiness and a hyperemia of a mucous membrane of a nose).

Calcium the gluconate is the regulator of exchange of calcium and phosphorus, has antiallergic effect, reduces permeability of vessels.

Rutoside interferes with development of a hyperpermeability and fragility of the vessels causing hemorrhagic processes at flu and also recover microcirculation.

Pharmacokinetics. Absorption and metabolism. Components of drug are quickly absorbed from a GIT and quickly enough metabolized. Meal extends time of achievement of Cmax in a blood plasma a little, but does not influence the absolute value of this indicator and bioavailability.

Removal. Components of drug are removed, mainly, by kidneys.

Indications to use:

— the infectious and inflammatory diseases (including a SARS, flu) which are followed by fever;

— pain syndrome of various genesis (head, muscular and joint pains).

Route of administration and doses:

Appoint inside. The adult - on 1-2 таб. 3 times/days, to children are from 6 to 12 years - on 1 таб. 3 times/days. Duration of reception makes from 3 to 5 days.

Features of use:

Use at pregnancy and feeding by a breast. Drug is contraindicated to use at pregnancy and in the period of a lactation (breastfeeding).

Use at abnormal liver functions. With care appoint drug at abnormal liver functions. At the expressed abnormal liver functions drug is contraindicated.

Use at renal failures. With care appoint drug at renal failures. At the expressed renal failures drug is contraindicated.

Special instructions. With care appoint drug at abnormal liver functions or kidneys.

For avoidance of overdose Agrippin along with other drugs containing paracetamol is not recommended to appoint.

During treatment by Agrippin it is necessary to avoid alcohol intake.

Use in pediatrics. Information on use of drug for children under 6 years is not provided.

Side effects:

From TsNS: dizziness, sleep disorders.

Allergic reactions: skin rash, bronchospasm.

At prolonged use of drug Agrippin in high doses development of hepatotoxic and nephrotoxic action is possible.

Interaction with other medicines:

Simultaneous use of drug Agrippin with the anticoagulants derivative of a cortisone, analgetics, NPVS, neuroleptics and ethanol increases risk of development of side effects of these drugs.

Contraindications:

— the expressed abnormal liver functions and kidneys;

— pregnancy;

— lactation (breastfeeding);

— blood diseases;

— hypersensitivity to drug components.

Overdose:

Symptoms: nausea, vomiting, perspiration, pallor of integuments.

Treatment: gastric lavage, purpose of absorbent carbon, performing symptomatic therapy.

Storage conditions:

Drug should be stored in dry, protected from light, the place, unavailable to children, at a temperature from 15 °C to 25 °C. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

10 pieces - packagings bezjyacheykovy planimetric (1) - packagings group.
10 pieces - packagings planimetric cell (1) - packagings group.