ÊÉæ® 19

General characteristics. Structure:

Active agents:

lysates of bacteria * 43,27 ml

* Structure of lysates of bacteria:

Streptococcus pneumoniae, type I of 1,11 ml

Streptococcus to a rpeshpotaa, type II of 1,11 ml

Streptococcus pneumoniae, type III of 1,11 ml

Streptococcus pneumoniae, type V of 1,11 ml

Streptococcus pneumoniae, type VIII of 1,11 ml

Streptococcus pneumoniae, type XII of 1,11 ml

Haemophilus influenzae, type In 3,33 ml

Klebsiella pneumoniae ss pneumoniae of 6,66 ml

Staphylococcus aureus ss aureus of 9,99 ml

Acinetobacter calcoaceticus of 3,33 ml

Moraxella catarrhalis of 2,22 ml

Neisseria subflava of 2,22 ml

Neisseria perflava of 2,22 ml

Streptococcus pyogenes group A of 1,66 ml

Streptococcus dysgalactiae group From 1,66 ml

Enterococcus faecium of 0,83 ml

Enterococcus faecalis of 0,83 ml

Streptococcus group G of 1,66 ml

Excipients:

Glycine of 4,25 g

Mertiolit sodium no more than 1,2 mg

Fragrance on the basis of nerol ** 12,50 mg

The water purified to 100 ml

** Composition of fragrance on the basis of nerol: linalol, alpha terpineol, geraniol, methyl антранилат, limonene, геранилацетат, linalyl acetate, diethylene glycol monoethyl ether, phenylethyl alcohol.

Description

Transparent colourless or with a yellowish shade liquid with a slight specific smell.

Pharmacological properties:

ÊÉæ® 19 increases specific and nonspecific immunity.

When spraying ИРС® 19 the finely divided aerosol which covers a mucous membrane of a nose that leads to bystry development of a local immune response is formed. Specific protection is caused by locally formed antibodies of a class of secretory immunoglobulins like A (IgA) interfering fixing and reproduction of contagiums on mucous. Nonspecific immunoprotection is shown in increase in phagocytal activity of macrophages and increase in maintenance of a lysozyme.

Indications to use:

Prevention of chronic diseases of upper respiratory tracts and bronchial tubes.
Treatment of acute and chronic diseases of upper respiratory tracts and bronchial tubes, such as rhinitis, sinusitis, laryngitis, pharyngitis, tonsillitis, tracheitis, ronkhit, etc.
Recovery of local immunity after the postponed flu and other viral infections.
Preparation for a planned operative measure on ENT organs and in the postoperative period.

ÊÉæ® 19 can appoint both adults, and children from 3-month age.

Route of administration and doses:

Drug is used intranazalno by aerosol introduction of 1 dose

(1 dose =1 short pressing of a spray).
for prevention by the adult and to children since 3 months on 1 dose of drug in each nasal course 2 times a day within 2 weeks (it is recommended to begin a course of treatment in 2-3 weeks prior to the expected rise in incidence);
for treatment of acute and chronic diseases of upper respiratory tracts and bronchial tubes:
to children from 3 months to 3 years on one dose of drug in each nasal course
2 times a day, after preliminary release from mucous separated, before disappearance of symptoms of an infection.
to children is more senior than 3 years and the adult on one dose of drug in each nasal course from 2 to 5 times a day before disappearance of symptoms of an infection;

for recovery of local immunity to children and adults after the postponed flu and other respiratory viral infections on 1 dose of drug in each nasal course 2 times a day within 2 weeks;

by preparation for a planned operative measure and in the postoperative period to adults and children on 1 dose of drug in each nasal course 2 times a day within 2 weeks (it is recommended to begin a course of treatment in 1 week prior to the planned operative measure).

In an initiation of treatment such reactions as sneezing and strengthening of allocations from a nose can take place. As a rule, they have short-term character. If these reactions accept a heavy current, it is necessary to reduce frequency rate of administration of drug or to cancel it.

 

Very important! The device correctly functions only under following conditions:

Put on a nozzle a bottle, properly center it and it is soft, without effort press it.

Now the device is ready to use.

WHEN SPRAYING DRUG IT IS NECESSARY TO KEEP THE BOTTLE IN VERTICAL POSITION AND NOT

TO THROW BACK THE HEAD.

If you incline a bottle during spraying, propellant will flow out for several seconds and the device will become useless. At regular use of drug the nozzle is not recommended to be removed.

If to leave drug for long time without use, the drop of liquid can evaporate and the formed crystals will cork outlet opening of a nozzle. This phenomenon occurs most often when the nozzle is removed and put in packaging by the upper end near a bottle down, previously without having washed out and without having dried it. If the nozzle was corked, press it several times that liquid could pass under the influence of excessive pressure. If it does not help, lower a nozzle for several minutes in warm water.

Features of use:

In an initiation of treatment temperature increase is in rare instances possible (≥ 39 °C). In this case treatment should be cancelled. However it is necessary to distinguish such state from the fervescence which is followed by an indisposition which can be connected with development of diseases of ENT organs. In the presence of system clinical signs of a bacterial infection it is necessary to consider expediency of purpose of system antibiotics.

At purpose of drugs on the basis of bacterial lysates for the purpose of immunostimulation by the patient with bronchial asthma emergence of attacks of asthma is possible. In this case it is recommended to stop treatment and not to accept drugs of this class in the future.

Precautionary measures at use

Bottle spray:
 
to protect from heating over 50 °C and from hit of a direct sunlight;
not to puncture a bottle;
not to burn a bottle even if it is empty.

Influence on ability to control of cars and other mechanisms

Use ИРС® 19 does not exert impact on the psychomotor functions connected with driving of the car or control of cars and mechanisms.

Side effects:

During reception ИРС®19 the following side effects both connected, and not connected with effect of drug can be noted.

Skin reactions: in rare instances, hypersensitivity reactions (a small tortoiseshell, a Quincke's disease) both skin eritemopodobny and ekzemopodobny reactions are possible.

From ENT organs and a respiratory organs: in rare instances — attacks of asthma and

cough.

In rare instances in an initiation of treatment it can be observed:

temperature increase (≥ 39 °C) without the visible reasons, nausea, vomiting, an abdominal pain, diarrhea, a nasopharyngitis, sinusitis, laryngitis, bronchitis.

Isolated cases of emergence of a Werlhof's disease and knotty erythema are described.

At emergence of the above-stated symptoms it is recommended to see a doctor.

Interaction with other medicines:

Cases of negative interaction with other medicines are unknown.

In case of clinical symptoms of a bacterial infection prescription of antibiotics against the background of the continuing use ИРС® 19 is possible.

Contraindications:

Hypersensitivity to drug or its components in the anamnesis.
ÊÉæ® 19 patients should not appoint with autoimmune diseases.

Use during pregnancy

There are no sufficient data about potentiality of teratogenic or toxic influence on a fruit during pregnancy therefore use of drug during pregnancy is not recommended.

Overdose:

Cases of overdose are unknown.

Storage conditions:

In strictly vertical position at a temperature not above 25 °C. Not to freeze. To store in the place, unavailable to children! Period of validity 3 years. Drug cannot be used after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

Spray nasal.

On 20 ml in the aerosol can from colourless transparent low-alkaline glass covered with a plastic blanket, which is under pressure of nitrogen with the valve of continuous action, complete with a nozzle from polyethylene of high density of white color. On a cylinder paste the self-adhesive label or apply marking on a plastic blanket with method of a stencil or dry offset printing.

1 cylinder complete with a nozzle and the application instruction is placed in a cardboard pack.