ÊÉæ® 19

General characteristics. Structure:

Spray nasal	100 ml
active agents:
lysates of bacteria	43,27 ml
structure of lysates of bacteria:
Streptococcus pneumoniae type I, II, III, V, VIII, XII on	1,11 ml
Staphylococcus aureus ss aureus	9,99 ml
Neisseria subflava	2,22 ml
Neisseria perflava	2,22 ml
Klebsiella pneumoniae ss pneumoniae	6,66 ml
Moraxella catarrhalis	2,22 ml
Haemophilus influenzae type B	3,33 ml
Acinetobacter calcoaceticus	3,33 ml
Enterococcus faecium	0,83 ml
Enterococcus faecalis	0,83 ml
Streptococcus pyogenes group A	1,66 ml
Streptococcus dysgalactiae group C	1,66 ml
Streptococcus group G	1,66 ml
excipients: glycine — 4,25 g; mertiolit sodium — no more than 1,2 mg; fragrance on the basis of Nerol (linalol, alpha terpineol, geraniol, methyl anthranilate, limonene, геранилацетат, diethylene glycol monoethyl ether, phenylethyl alcohol) — 12,5 mg; the water purified — to 100 ml

Pharmacological properties:

Pharmacological action - increasing specific and nonspecific immunity.

Pharmacodynamics. ÊÉæ® 19 increases specific and nonspecific immunity. When spraying ИРС® 19 the finely divided aerosol which covers a mucous membrane of a nose that leads to bystry development of a local immune response is formed. Specific protection is caused by locally formed antibodies of a class of secretory immunoglobulins of type A (IgA) interfering fixing and reproduction of contagiums on mucous. Nonspecific immunoprotection is shown in increase in phagocytal activity of macrophages and increase in maintenance of a lysozyme.

Indications to use:

- prevention of chronic diseases of upper respiratory tracts and bronchial tubes;
- treatment of acute and chronic diseases of upper respiratory tracts and bronchial tubes (rhinitis, sinusitis, laryngitis, pharyngitis, tonsillitis, tracheitis, bronchitis), etc.;
- recovery of local immunity after the postponed flu and other viral infections;
- preparation for a planned operative measure on ENT organs and in the postoperative period.

Route of administration and doses:

Intranazalno, by aerosol introduction of 1 dose (1 dose = 1 short pressing of a spray). When spraying drug it is necessary to keep a bottle in vertical position and not to throw back the head.

For prevention by the adult and to children from 3-month age (for 2–3 weeks before the expected rise in incidence) — on 1 dose of drug in each nasal course 2 times a day during 2 weeks.

For treatment of acute and chronic diseases of upper respiratory tracts and bronchial tubes: to adults and children 3 years — on 1 dose of drug in each nasal course of 2-5 times a day are more senior; to children from 3 months to 3 years — on 1 dose of drug in each nasal course 2 times a day (after preliminary release from mucous separated). Treatment is carried out to disappearance of symptoms of an infection.

For recovery of local immunity after the postponed flu and other respiratory viral infections: to adults and children — on 1 dose of drug in each nasal course 2 times a day during 2 weeks.

By preparation for a planned operative measure and in the postoperative period: to adults and children — on 1 dose of drug in each nasal course 2 times a day during 2 weeks (it is recommended to begin a course of treatment for 1 week before the planned operative measure).

In an initiation of treatment such reactions as sneezing and strengthening of allocations from a nose can take place. As a rule, they have short-term character. If these reactions accept a heavy current, it is necessary to reduce frequency rate of administration of drug or to cancel it.

If to leave drug for long time without use, the drop of liquid can evaporate and the formed crystals will cork outlet opening of a nozzle. This phenomenon happens most often when the nozzle is removed and put in packaging by the upper end near a bottle down, previously without having washed out and without having dried it. At obstruction of a nozzle do several pressing in a row that liquid could pass under the influence of excessive pressure. If it does not help, the nozzle is lowered for several minutes in warm water.

Features of use:

Use of IRS 19® does not exert impact on the psychomotor functions connected with driving of the car or control of cars and mechanisms.

At purpose of drugs on the basis of bacterial lysates for the purpose of immunostimulation by the patient with bronchial asthma emergence of attacks of asthma is possible. In this case it is recommended to stop treatment and not to accept drugs of this class in the future.

Precautionary measures at use
Bottle spray:
- to protect from heating over 50 °C and from hit of a direct sunlight;
- not to puncture a bottle;
- not to burn a bottle even if it is empty.

Side effects:

During reception ИРС® 19 the following side effects both connected, and not connected with effect of drug can be noted.
Skin reactions: hypersensitivity reactions (a small tortoiseshell, a Quincke's disease) both skin eritemopodobny and ekzemopodobny reactions are in rare instances possible.
From ENT organs and a respiratory organs: seldom — attacks of asthma and cough.

In rare instances in an initiation of treatment can be observed — fervescence (≥39 °C) without the visible reasons, nausea, vomiting, an abdominal pain, diarrhea, a nasopharyngitis, sinusitis, laryngitis, bronchitis.

Isolated cases of emergence of a Werlhof's disease and knotty erythema are described.

At emergence of the above-stated symptoms it is recommended to see a doctor.

Interaction with other medicines:

Cases of negative interaction with other HP are unknown. In case of clinical symptoms of a bacterial infection prescription of antibiotics against the background of the continuing use ИРС® 19 is possible.

Contraindications:

- hypersensitivity to drug or its components in the anamnesis;
- autoimmune diseases.

Use at pregnancy and feeding by a breast
It is not recommended during pregnancy (data on potentiality of teratogenic or toxic influence on a fruit are absent).

Overdose:

Cases of overdose are unknown.

Storage conditions:

At a temperature not above 25 °C (not to freeze). In strictly vertical position.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

In bottles on 20 ml (60 doses); in a box 1 bottle.