Kandiderm

General characteristics. Structure:

Active agents: Clotrimazolum – 10,0 mg, beclomethasone Dipropionas – 0,25 mg, Gentamycini sulfas that is equivalent to gentamycin – 1 mg

Excipients: propylene glycol, цетомакрогол, vaseline, paraffin liquid, benzyl alcohol, methylparahydroxybenzoate (methylparaben), пропилпарагидроксибензоат (propylparaben), butyl hydroxytoluene, sodium dihydrophosphate monohydrate, sodium hydrophosphate, the water purified.

Pharmacological properties:

Anti-inflammatory, antiallergic, antibacterial, antifungal drug.
Clotrimazolum has antifungal effect due to disturbance of synthesis of the ergosterol which is a component of a cellular membrane of mushrooms. It is active in the relation: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).
Beclomethasone renders antiinflammatory, antiallergic, anti-exudative and antipruritic action. Slows down accumulation of leukocytes, release of lizosomalny enzymes and mediators of an inflammation, phagocytosis oppresses, reduces vascular and fabric permeability, interferes with formation of inflammatory hypostasis.
Gentamycin - an antibiotic of a broad spectrum of activity from group of aminoglycosides, has bactericidal effect concerning gram-negative bacteria - Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.

Pharmacokinetics. Researches of pharmacokinetics of drug were not conducted.

Indications to use:

- the dermatosis complicated by consecutive infection;
- epidermophitia of feet;
- the dermatomycoses (including with localization in inguinal area) caused by activators, sensitive to drug.

Route of administration and doses:

Outwardly. Cream is applied with a thin layer on affected areas of skin by 2 times a day (in the morning and in the evening). Duration of treatment depends on efficiency and portability of therapy and makes, as a rule, 2-4 weeks (no more). To children (7-16 years) drug is appointed only strictly to destination and under control of the doctor.

Features of use:

Drug is not used in ophthalmology. Not to apply on skin in eyes. For the purpose of increase in efficiency of therapy use of occlusive bandages is possible. It is necessary to consider that at the same time transdermalny absorption of beclomethasone and gentamycin which leads to increase in risk of development of system side effects amplifies.
At manifestation of steady bacterial or fungal microflora it is necessary to stop use of drug and to appoint the corresponding therapy. Development of cross resistance with aminoglikozidny antibiotics is possible.

Side effects:

Burning sensation, hyperemia, erythema, peeling, hypostasis, dryness, maceration and atrophy of skin; striya, hypertrichosis, folliculitis, heat rash, small tortoiseshell, steroid eels, perioral dermatitis, allergic contact dermatitis, telangiectasia, hypopigmentation, pyoderma, furunculosis. At prolonged use system side effects including oppression of function of bark of adrenal glands are possible.

Interaction with other medicines:

Interaction of drug with other medicines is not revealed.

Contraindications:

Tuberculosis cutis, skin displays of syphilis, chicken pox, herpes simplex, skin reactions after vaccination, hypersensitivity to drug components, children's age up to 7 years, pregnancy, the lactation period, open wounds.

Use in pediatrics:
To children drug is appointed only according to strict indications and under medical control as development of the system side effects connected with beclomethasone is possible. At use of drug on extensive surfaces and/or under an occlusive bandage function suppression gipotalamo-pituitary adrenal system and development of symptoms of a hypercorticoidism is possible, decrease in excretion of a growth hormone, increase in intracranial pressure can be observed.

Overdose:

At exceeding of the recommended doses development of symptoms of a hypercorticoidism is possible: increase in body weight, formation of hypostases, giperteziya, glucosuria, hypopotassemia. Treatment: symptomatic therapy, if necessary carry out correction of electrolytic balance. Gradual drug withdrawal is recommended.

Storage conditions:

In the place protected from light at a temperature not above 25 °C. Not to freeze.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

External use cream.
On 15 g in an aluminum tuba with the cover having an edge for piercing. Each tuba together with the instruction on a medical use is placed in a cardboard pack.