Klenzit

General characteristics. Structure:

Active agent: адапален 1 mg.

Excipients: dinatrium эдетат, carbomer 940 (карбопол 940), propylene glycol, methylparahydroxybenzoate, phenoxyethanol, half-oxameasures 407, sodium hydroxide, the water purified.

Pharmacological properties:

Adapalen - a retinoid metabolite, has komedonolitichesky and antiinflammatory activity, normalizes processes of keratinization and epidermal differentiation. The mechanism of action of an adapalen is based on interaction with specific at - receptors of epidermal cells of skin. Action of an adapalen is resulted, in particular, by decrease in "stseplennost" of epithelial cells to the mouth of a grease and hair follicle and reduction of premises for formation of microcomedones. Adapalen has antiinflammatory effect of in vivo and in vitro, influencing inflammation factors by inhibition of migration of leukocytes in the center of an inflammation and metabolism of arachidonic acid.

Pharmacokinetics. Absorption of an adapalen through skin is very low (about 4% of the applied dose). Excretion comes from an organism, mainly, through bile.

Indications to use:

Acne rash.

Route of administration and doses:

Outwardly. Before use of gel of Klenzit it is necessary to clear and dry up face skin. Evenly to apply with a light touch gel on the struck surface once a day before going to bed on clean dry skin, avoiding hit of drug in eyes and on lips. The therapeutic effect develops after 4-8 weeks of treatment, permanent improvement after 3-month treatment.
In certain cases because of short-term irritation of skin treatment can be suspended before disappearance of signs of irritation.
The repeated course of treatment is possible after consultation with the doctor.

Features of use:

To avoid hit of gel in eyes and on lips.
At accidental hit of drug on mucous eyes, a mouth or a nose carefully to wash out them warm water.
To avoid direct sunshine since the irritation of skin can appear. Treatment can be continued if solar exposure is minimized (use of sunglasses and hats).
Simultaneous use of cosmetics with the drying and irritating effect on skin is not recommended (for example, spirits or alkogolsoderzhashchy means).
Adapalen applied on skin in the evening it is possible to combine with the drugs for treatment of eels used in the morning.

Side effects:

Irritation of skin (treatment needs to be suspended before disappearance of irritation of skin or to reduce use frequency).

Interaction with other medicines:

As drug does not interact with oxygen and perhaps simultaneous treatment of acne rash such drugs as clindamycin phosphate or benzoyl peroxide does not collapse under the influence of light.

Contraindications:

Hypersensitivity to one of drug ingredients, pregnancy, the lactation period.

With care
Dermatitis, eczema.

Pregnancy and period of a lactation
Use of drug is not recommended during pregnancy and breastfeeding.

Overdose:

The overdose is improbable.

Storage conditions:

In the place protected from light at a temperature below 25 °C.
Not to freeze.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Gel for external use of 0.1%. On 15 g and on 30 g in the varnished aluminum tubas having a nozzle with the closed end with the cover having an edge for piercing. One tuba together with the application instruction is located in a cardboard pack.