Differin gel

General characteristics. Structure:

Active agent: адапален 1,0 mg

Excipients: propylene glycol of 40,0 mg, methylparahydroxybenzoate — 1,0 mg, phenoxyethanol — 2,5 mg, carbomer 940 P — 11,0 of mg, dinatrium эдетат — 1,0 mg, half-oxameasures of 182 — 2,0 mg, sodium hydroxide to pH 5, the water purified to 1 g.

Pharmacological properties:

Adapalen — a retinoid metabolite, has komedonolitichesky and antiinflammatory activity, normalizes processes of keratinization and epidermal differentiation. The mechanism of action of an adapalen is based on interaction with specific γ-receptors of epidermal cells of skin. Action of an adapalen is resulted, in particular, by decrease in "stseplennost" of epithelial cells to the mouth of a grease and hair follicle and reduction of premises for formation of microcomedones. Adapalen has antiinflammatory effect of in vivo and in vitro, influencing inflammation factors by inhibition of migration of leukocytes in the center of an inflammation and metabolism of arachidonic acid.

PHARMACOKINETICS. Absorption of an adapalen through skin is very low (about 4% of the applied dose). Excretion from an organism happens, mainly, to bile.

Indications to use:

Acne rash.

Route of administration and doses:

Outwardly. Evenly to apply with a light touch gel on the struck surface once a day before going to bed on clean dry skin, avoiding hit of gel in eyes and on lips.
The therapeutic effect develops after 4–8 weeks of treatment, permanent improvement after 3-month treatment.
In certain cases the number of applications or treatment can be reduced because of short-term irritation of skin it is suspended before disappearance of signs of irritation.
The repeated course of treatment is possible after consultation with the doctor.

Features of use:

To avoid hit of gel in eyes and on mucous membranes.
At accidental hit of drug on mucous membranes of eyes, a mouth or a nose carefully to wash out them warm water.
To avoid direct sunshine since the slight irritation of skin can appear.
Treatment can be continued if solar exposure is minimized (use of sunglasses and hats).
Simultaneous use of cosmetics with the drying or irritating effect on skin is not recommended (for example, spirits or alcohol-containing means).
Adapalen applied on skin in the evening it is possible to combine with the drugs for treatment of eels used in the morning.

Side effects:

Frequency of side reactions is distributed in the following order:
often (in 1%–10% of cases); infrequently (in 0,1%-1% of cases); seldom (in 0,01%-0,1% of cases);
very seldom (less than 0,01% of cases), including messages on isolated collateral cases.
From skin and a hypodermic fatty tissue:
Often: xeroderma, irritation of skin, skin burning sensation, erythema.
Infrequently: contact dermatitis, sensation of discomfort, sunblister, itch, skin peeling, acne rash.
Frequency is unknown: dermatalgia, cutaneous swelling.
From organs of sight:
Frequency is unknown: irritation a century, an itch a century, a swelling a century, an erythema in the field of a century.
In case of development of irritation of skin, treatment needs to be suspended before disappearance of irritation or to reduce use frequency.

Interaction with other medicines:

As drug does not interact with oxygen and does not collapse under the influence of light, it can be applied with other local and system drugs to treatment of acne rash, such as clindamycin phosphate or benzoyl peroxide.
To be careful at combined use with the drugs having the irritating or drying effect including the drugs containing sulfur, Resorcinolum or salicylic acid (strengthening of side effect is possible).

Contraindications:

Hypersensitivity to one of drug ingredients.

USE IN PEDIATRICS
Differin is intended for use for adults and children 12 years are more senior.

PREGNANCY AND BREASTFEEDING
Use of drug is not recommended during pregnancy.
Differin it is possible to apply during breastfeeding. To avoid contact impact on the child, it is not necessary to apply Differin on breast skin.

WITH CARE
Dermatitis, eczema.

Overdose:

The overdose is improbable.

Storage conditions:

At a temperature not above 25 °C. Not to freeze.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Gel for external use of 0,1% on 30 g in a polyethylene tuba of low density, densely screwing up polypropylene cover. On 1 tuba with the application instruction place in a cardboard box.