Lizoril

General characteristics. Structure:

Active agent: lisinopril of 2.5 mg
 
Active agent: lisinopril of 5 mg

Excipients: starch, Mannitolum, phosphate dicalcium dihydrate, magnesium stearate, dye ferrous oxide red.

Active agent: lisinopril of 10 mg

Excipients: starch, Mannitolum, dicalcium phosphate (dihydrate), magnesium stearate, dye ferrous oxide red.

Active agent: lisinopril of 20 mg

Excipients: starch, Mannitolum, dicalcium phosphate (dihydrate), magnesium stearate, dye ferrous oxide red.

Pharmacological properties:

APF inhibitor. Breaks formation of angiotensin II, reducing its vasoconstrictive action and the stimulating influence on products of Aldosteronum in adrenal glands. Lizoril reduces OPSS, reduces an afterload by heart, the ABP reduces, causes increase in cordial emission and increase in tolerance of a myocardium to loadings in patients with heart failure.
Drug reduces also preload of a myocardium and reduces pressure in a small circle of blood circulation. Besides, Lizoril reduces resistance of renal vessels and improves blood circulation in kidneys.
At prolonged use the hypertrophy of a myocardium and walls of arteries of resistive type decreases. Drug improves blood supply of an ischemic myocardium.
Decrease in the ABP is noted in 1 h after administration of drug.
Lizoril's action after reception in a dose of 10 mg continues 24 h.

Pharmacokinetics. Absorption. Bioavailability makes 25-50% irrespective of meal. Cmax in a blood plasma is reached in 7 h.

Distribution and metabolism. At administration of drug of 1 time/days of Css it is reached in 3 days. Lisinopril does not contact blood proteins, does not biotransformirutsya in an organism.

Removal. It is removed with urine in not changed look.
T1/2 makes 12.6 h even at multiple dose.

Pharmacokinetics in special clinical cases. Removal of lisinopril decreases at KK less than 30 ml/min.

Indications to use:

— arterial hypertension;
— heart failure.

Route of administration and doses:

At treatment of arterial hypertension drug appoint 5 mg of 1 times/days in an initial dose. An average dose – 10 mg of 1 times/days. If necessary it is possible to increase a dose to 40 mg/days.

At treatment of heart failure the initial dose makes 2.5 mg. If necessary it is possible to increase a dose to 10 mg/days.

To the patients with disturbances of water and electrolytic balance, a renal failure, renovascular hypertensia and also receiving diuretics, the dose is selected individually, since 1:25 mg/days.

Features of use:

With care appoint drug to patients with renal failures, and also to the patients receiving diuretics.
In cases of development of allergic reactions treatment by Lizoril should be stopped.

Control of laboratory indicators
Before therapy by Lizoril it is necessary to check laboratory indicators of function of kidneys, water and electrolytic exchange and, if necessary, to offset loss of liquid and salts. In the course of treatment it is necessary to control periodically quantity of leukocytes of blood, especially at patients with autoimmune and renal diseases, and also the content of potassium in a blood plasma.

Side effects:

From the alimentary system: nausea, vomiting; in some cases - increase in activity of hepatic transaminases.
Co of the party of TsNS: headache, dizziness.
Allergic reactions: Quincke's edema, skin rash.
From cardiovascular system: arterial hypotension, tachycardia.
From system of a hemopoiesis: seldom - a neutropenia, thrombocytopenia, reduction of a hematocrit.
From respiratory system: dry cough; seldom - development of bronchitis.
Others: muscular spasms, hyperpotassemia; seldom - renal failures.

Interaction with other medicines:

At simultaneous use with NPVS, estrogen and sympathomimetics decrease in efficiency of action of Lizoril is possible.
The combined use with beta-blockers, blockers of calcium channels, diuretics and other antihypertensives increases expressiveness of hypotensive action of Lizoril.
At simultaneous use of Lizoril with kaliysberegayushchy diuretics development of a hyperpotassemia is possible.
At combined use with lithium drugs Lizoril can slow down removal of lithium from an organism.

Contraindications:

— hypersensitivity to drug or other APF inhibitors;
— the expressed renal failures;
— stenosis of renal arteries;
— stenosis of the mouth of an aorta;
— pregnancy;
— lactation (breastfeeding);
Drug is not appointed to children.

Use of drug LIZORIL at pregnancy and feeding by a breast
Lizoril is contraindicated to use at pregnancy.
In need of Lizoril's use in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Overdose:

Symptoms: arterial hypotension.
Treatment: in/in administration of isotonic solution of sodium of chloride, carrying out a hemodialysis.

Storage conditions:

Drug should be stored in cool, dry, protected from light and the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Tablets of 2.5 mg: 28 or 30 pieces.
Tablets of 5 mg: 28 or 30 pieces.
Tablets of 10 mg: 28 or 30 pieces.
Tablets of 20 mg: 28 or 30 pieces.