Neuron

General characteristics. Structure:

Active ingredients: 25 mg of thiamin of mononitrate, 2,5 mg of Riboflavinum, 40 mg of a pyridoxine of a hydrochloride, 0,25 mg of cyanocobalamine.

Excipients: thiourea, dinatrium эдитат, lactose, sodium methylparaben (Е 219), sodium propylparaben (Е 217), silicon dioxide colloid anhydrous, talc, magnesium stearate, sodium is krakhmalglikolit, starch corn.

Tablet cover: a gidroksipropilmetiltsellyuloza, talc, titanium dioxide (E 171), azoic dye (понсо - 4R) (E124), polyethyleneglycol.

The complex polyvitaminic drug playing an important role in exchange of carbohydrates, proteins and fats in an organism. Takes part in all key metabolic processes in fabrics of a nervous system, heart, muscles and uniform elements of blood, in processes of carrying out nervous impulse in synapses.

Pharmacological properties:

Pharmacodynamics. The complex of vitamins of group V. Tiamin (B1 vitamin) in a human body as a result of processes of phosphorylation turns into cocarboxylase which is a coenzyme of many enzymatic reactions. Thiamin plays an important role in exchange of carbohydrates, proteins and fats in an organism. Takes part in all key metabolic processes in fabrics of a nervous system, heart, muscles and uniform elements of blood, in processes of carrying out nervous impulse in synapses.

Riboflavinum (B2 vitamin) regulates oxidation-reduction processes, exchange of carbohydrates, proteins and fats. It is necessary for maintenance of function of an organ of sight, skin, takes part in hemoglobin synthesis.

The pyridoxine (B6 vitamin) is necessary for maintenance of normal function of the central and peripheral nervous system. In a fosforilirovanny form is a coenzyme in metabolism of amino acids (processes of decarboxylation, transamination, etc.). Takes part in biosynthesis of neurotransmitters: dopamine, noradrenaline, adrenaline, serotonin, histamine.

Cyanocobalamine (B12 vitamin) is necessary for a normal hemopoiesis and maturing of erythrocytes. He also takes part in a number of the biochemical reactions providing life activity of an organism — in transferring of methyl groups, synthesis of nucleic acids, protein, in exchange of amino acids, carbohydrates, lipids. B12 vitamin influences metabolic processes in a nervous system (synthesis of RNA, DNA, a myelin, on lipidic composition of cerebrosides and phospholipids). Coenzymatical forms of cyanocobalamine — methylcobalamine and аденозилкобаламин — are necessary for processes of replication and growth of cells.

Components of drug belong to water-soluble vitamins that excludes a possibility of their cumulation in an organism.

Pharmacokinetics. Thiamin and a pyridoxine are absorbed in upper parts of a GIT. Absorption of cyanocobalamine is caused by existence of an internal factor in a stomach and upper parts of intestines, further cyanocobalamine transport in fabric is carried out by transport protein transcobalamine II. Thiamin, a pyridoxine and cyanocobalamine are metabolized in a liver. Riboflavinum in an organism turns into a coenzyme — flavin a mononucleotide, and then into other coenzyme — flavin adeninedinucleotide. About 60% of metabolites contact proteins of a blood plasma.

Thiamin and pyridoxine are removed with urine (8–10% in not changed state). At overdose removal of thiamin and a pyridoxine through intestines considerably increases. B12 vitamin is emitted with bile and enters a cycle of enterogepatichesky recirculation, a part of the accepted dose the most part — for the first 8 h after reception is excreted with urine. However with urine only the insignificant amount of the vitamin (6–30%) accepted inside is removed. B12 vitamin gets through a placenta and is emitted with breast milk. Riboflavinum is removed with urine, partially in the form of a metabolite.

Indications to use:

Polyneuropathy of various etiology, neuritis and neuralgia, the radicular syndrome caused by degenerative changes of a backbone, a sciatica, a lumbago, a plexitis, intercostal neuralgia, an epileptiform neuralgia, paresis of a facial nerve; deficit of the corresponding vitamins at various states, for example, at the increased need for vitamins B the period of pregnancy and feeding by a breast, during periods, at fever, chronic diseases, an intensive exercise stress and increased fatigue, during the postoperative period, at smokers; disturbance of absorption of vitamins from a digestive tract at a liver failure, exocrine insufficiency of a pancreas, chronic diarrhea, disturbance of food and damage of a mucous membrane of intestines; an alimentary vitamin deficiency at observance of deprivation diets, a food imbalance; the vitamin deficiency caused by treatment by the drugs increasing metabolism of vitamins (antituberculous, antiepileptic and other remedies).

Route of administration and doses:

The adult — on 1 tablet 1–3 times a day after food for 30 days; to children aged from 3 years — on 1 tablet of 1 times a day after food for 30 days. If necessary the course is repeated.

Features of use:

It is not necessary to appoint drug before establishment of the diagnosis in view of a possibility of emergence of the larvate symptoms of a subacute degeneration of a spinal cord.

Use during pregnancy or feeding by a breast. Drug can be used during pregnancy or feeding by a breast.

Ability to influence speed of response at control of motor transport or other mechanisms. Drug can cause drowsiness therefore at control of motor transport or other mechanisms it is necessary to show care.

Children. Drug can be used, since 3 years

Side effects:

In isolated cases — nausea, tachycardia, skin manifestations in the form of urticaria and an itch. At reception in the recommended doses side effects are improbable.

Interaction with other medicines:

Alcohol intake, use of oral contraceptives, diuretic drugs can reduce thiamin level. Additional administration of drugs, containing magnesium as the last is necessary for transformation of thiamin to its active form is reasonable.

Patients who accept a levodopa as vitamin reduces efficiency of protivoparkinsonichesky means cannot appoint B6 vitamin. B6 vitamin can increase the intracellular level of magnesium and zinc.

Reduce the level of a pyridoxine and oral contraceptives, an isoniazid, penicillin, theophylline, Cycloserinum reduce its effect.

The pyridoxine can reduce concentration of anticonvulsant drugs in blood, for example, of Phenytoinum, phenobarbital.

In blood nitrous oxide, the general anesthetics, antiepileptic drugs and alcohol can reduce B12 vitamin level.

Contraindications:

Hypersensitivity to drug components, simultaneous treatment by a levodopa.

Overdose:

Hypervitaminosis symptoms are possible: xeroderma, itch, urticaria.

Storage conditions:

To store at a temperature not over 25 ºС in original packaging and the place, unavailable to children. Period of validity 2 years.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in the blister, on 3 blisters in a cardboard box together with the application instruction.