Синекод®

General characteristics. Structure:

Active agent: Butamirata citrate - 1,5 mg/ml.

Excipients: sorbitol solution of 70% of mom, glycerin (глицерол), sodium saccharin, the benzoic acid, vanillin, ethanol of 96% about/about., sodium hydroxide of 30% of mom, the water purified.

Description: colourless transparent liquid with a vanilla smell

Pharmacological properties:

Butamirat, active agent of drug Sinekod, is an antibechic of the central action, neither chemically, nor pharmacological not belonging to opium alkaloids. Renders expectorant, moderate bronkhodilatiruyushchy and antiinflammatory action, has a direct impact on the tussive center, improves spirometry indicators (reduces resistance of respiratory tracts) and blood oxygenation.

Pharmacokinetics. Butamirat is quickly and completely soaked up at intake. After reception of 150 mg of a butamirat, the maximum concentration in plasma of the main metabolite (2-phenyl-butyric acid) is reached approximately in 1.5 h and makes 6.4 mkg/ml. The elimination half-life makes 6 hours. At repeated purpose of drug its concentration in blood remains linear and cumulation is not observed. Hydrolysis of a butamirat, originally to 2-phenyl-butyric acid and diethylaminoethoxyethanol, begins in blood. These metabolites also have antibechic activity. Like a butamirat, metabolites possess almost maximum (about 95%) extent of linkng with proteins of plasma that causes, in addition, their long plasma elimination half-life. Metabolites are removed mainly with urine, and metabolites with acid reaction are substantially connected with glucuronic acid.

Indications to use:

Dry cough of any etiology (including at whooping cough). Suppression of cough in before - and the postoperative period at surgical interventions and a bronkhoskopiya.

Route of administration and doses:

Inside, before food.
To children from 3 to 6 years - on 5 ml 3 times a day;
6-12 years - on 10 ml 3 times a day;
12 years are also more senior - on 15 ml 3 times a day;
the adult - on 15 ml 4 times a day.
Use a measured cap it (is applied).

Features of use:

Syrup contains saccharin and sorbitol therefore can be appointed a sick diabetes mellitus in quality of sweeteners.

Side effects:

Skin rash, nausea, diarrhea, dizziness (frequency less than 1%), allergic reactions.

Interaction with other medicines:

Any medicinal interactions for a butamirat are not described.

Contraindications:

Hypersensitivity to drug components, children's age up to 3 years (for children up to 3 years it is possible to apply Sinekod drops to intake).

Use during pregnancy and a lactation

In the researches conducted at animals undesirable impacts on a fruit were not noted. Controlled researches at pregnant women were not conducted. In this regard Sinekod it is not necessary to apply in the I trimester of pregnancy. In II and III trimesters Sinekod's use is possible taking into account advantage for mother and potential risk for a fruit. Considering lack of data on release of active agent with maternal milk, Sinekod's appointment in the period of a lactation is not recommended.

Overdose:

Symptoms: drowsiness, nausea, vomiting, diarrhea, loss of sense of equilibrium and lowering of arterial pressure.

Treatment: absorbent carbon, salt laxatives, maintenance of function of cardiovascular and respiratory systems.

Storage conditions:

Period of validity of 5 years. Not to use after expiry date. At a temperature not above 30 °C, in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 100 ml and 200 ml of syrup in bottles from dark glass with the cover from polyethylene and polypropylene supplied with system from unauthorized opening by children and with a measured cap from polypropylene. 1 bottle together with the application instruction is placed in a cardboard pack