Синекод®

General characteristics. Structure:

Active ingredient: Butamirata citrate of 5 mg/ml.
Excipients: solution of sorbitol of 70% in/in, glycerin (глщерол), sodium saccharin, the benzoic acid, vanillin; ethanol of 96% about/about., sodium hydroxide of 30% in/in, the water purified

Description: From colourless to colourless with a yellowish shade transparent жмдкостъ from a zapakhomvaniljnila.

Pharmacological properties:

Butamirat, active agent of drug Sinekod, is an antibechic of the central action, neither chemically, nor pharmacological not relating to an alkaloidamopiya. Renders expectorant, moderate bronkhodilatiruyushchy and antiinflammatory action, has a direct impact on the tussive center, improves spirometry indicators (reduces resistance of respiratory tracts) and blood oxygenation.

Pharmacokinetics. Butamirat is quickly and completely soaked up at intake. After reception of 150 mg of a butamirat, the maximum concentration in plasma of the main metabolite (2-phenyl-butyric acid) is reached approximately in 1.5 h and makes 6.4 mkg/ml. The elimination half-life makes 6 hours. At repeated purpose of drug its concentration in blood remains linear and cumulation is not observed. Hydrolysis of a butamirat, originally to 2-phenyl-butyric acid and diethylaminoethoxyethanol, begins in blood. These metabolites also have antibechic activity. Like a butamirat, metabolites possess almost maximum (about 95%) extent of linkng with proteins of plasma that causes, in addition, their long plasma elimination half-life. Metabolites are removed mainly with urine, and metabolites with acid reaction are substantially connected with glucuronic acid.

Indications to use:

Dry cough of any etiology (including at whooping cough). Suppression of cough in before - and the postoperative period at surgical interventions and a bronkhoskopiya.

Route of administration and doses:

Inside, before food.
To children from 2 months to 1 year - on 10 drops 4 times a day;
from 1 to 3 years - on 15 drops 4 times a day;
of 3 years is also more senior - on 25 drops 4 times a day.

Features of use:

Drops contain saccharin and sorbitol therefore can be appointed a sick diabetes mellitus in quality of sweeteners.

Side effects:

Skin rash, nausea, diarrhea, dizziness (frequency less than 1%), allergic reactions.

Interaction with other medicines:

Any medicinal interactions for a butamirat are not described.

Contraindications:

Hypersensitivity to drug components, children's age up to 2 months.

Use during pregnancy and a lactation
In the researches conducted at animals undesirable impacts on a fruit were not noted. Controlled researches at pregnant women were not conducted. In this regard Sinekod it is not necessary to apply in the I trimester of pregnancy. In II and III trimesters Sinekod's use is possible taking into account advantage for mother and potential risk for a fruit. Considering lack of data on release of active agent with maternal milk, Sinekod's appointment in the period of a lactation is not recommended.

Overdose:

Symptoms: drowsiness, nausea, vomiting, diarrhea, loss of sense of equilibrium and lowering of arterial pressure.
Treatment: absorbent carbon, salt laxatives, maintenance of function of cardiovascular and respiratory systems.

Storage conditions:

Period of validity - 5 years. Not to use after expiry date. Drug should be stored at a temperature below 30 °C, to protect from influence of high temperatures. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Drops for intake for children on 20 ml in bottles from dark glass supplied with a dropper doser from polyethylene of low density and polypropylene krppka. Each bottle together with the instruction is located in a cardboard pack.