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Instenon

Препарат Инстенон. Nycomed Austria GmbH (Никомед Австрия ГмбХ) Австрия


Producer: Nycomed Austria GmbH (Nikomed Austria Gmbh) Austria

Code of automatic telephone exchange: C01EX

Release form: Liquid dosage forms. Solution for injections.

Indications to use: Disturbance of cerebral circulation. Dizziness.


General characteristics. Structure:

Active agent: Hexobendinum hydrochloride of 5 mg, этофиллин 50 mg, этамиван 25 mg
Excipients: sodium эдетат. propylene glycol, water for injections

Description. Colourless, transparent solution.




Pharmacological properties:

ИНСТЕНОН® is the combined drug improving cerebral circulation and a metabolism. Etamivan due to activation of a reticular formation normalizes a functional condition of neural complexes of bark and subcrustal and trunk structures.
Hexobendinum increases utilization of glucose and oxygen due to activation of anaerobic glycolysis and pentozny cycles (are implemented only in the conditions of ischemia and a hypoxia when the cycle of aerobic oxidizing phosphorylation is broken). Stimulation of anaerobic oxidation gives power substrate for synthesis and exchange of mediators and recovery of synoptic transfer which depression, along with destruction of membranes of neurons, is the leading pathogenetic mechanism of disorders of consciousness and neurologic nartleniye at a hypoxia and ischemia of a brain. Stabilizes physiological mechanisms of an autoregulyation of a cerebral and cardial blood-groove that is connected with impact of a lactate and pyruvate (products of anaerobic glycolysis) on the receptor device of intracranial arterioles and capillaries.
Etofillin activates metabolism of a myocardium, increases the minute volume of heart that promotes increase in perfused pressure in vessels of a regional area of ischemia. At the same time the ABP does not change system. Exciting action on a nervous system is shown also in stimulation of subcrustal educations, a mesencephalon and the trunk centers and kernels (respiratory, vasomotor, the centers of vegetative regulation, and also kernels craniocereberal, first of all - wandering).
At appointment as the patient with an ischemic stroke, the closed craniocereberal injury recovery of the broken consciousness of the patient, regression of neurologic disturbances, activation of the vegetative sphere is noted.


Indications to use:

Diseases of a brain of vascular and age character, effect of insufficiency of blood supply, postinsultny states, dizzinesses caused by functional disorders of a brain.


Route of administration and doses:

Depending on weight of a state 1-2 times a day on 1 ampoule intramusculary, or intravenously slowly; or 1-2 times a day on one ampoule intramusculary, or intravenously slowly; or 1-2 times a day on one ampoule in the form of drop infusion together with 250 ml of 5% of solution of levulose. In process of improvement of a state treatment can be continued by peroral forms of drug (a tablet, coated). In some cases at bystry introduction the arterial pressure therefore duration of introduction of one ampoule has to make not less than 3 min. can go down.


Features of use:

During treatment it is necessary to be careful at occupation potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.


Side effects:

At use of high doses the headache, a hyperemia of the person, decrease in the ABP in some cases can be observed.


Interaction with other medicines:

ИНСТЕНОН® can interact with other drugs. Treat them: the medicines reducing activity of thrombocytes (acetylsalicylic acid, etc.). Effect of these drugs can amplify Hexobendinum.
Very high doses of caffeine can weaken action ИНСТЕНОНа® (it is necessary to avoid reception of large numbers of coffee and tea).


Contraindications:

ИНСТЕНОН® it is impossible to apply in the following cases: a condition of strong excitement and spasms, manifestations of the increased brain pressure (signs: a long headache, vomiting, a vision disorder), epilepsy, hemorrhage in a brain.
It is necessary to be careful at recently had strokes and a stenosis of a carotid artery owing to arteriosclerosis.

Use during pregnancy and a lactation. At pregnancy and during breastfeeding ИНСТЕНОН® is accepted only on doctor's orders.


Overdose:

At overdose headaches, tachycardia and a hyperemia of the person can be observed. In these cases cancellation of administration of drug with the subsequent decrease in a dosage is recommended.


Storage conditions:

At a temperature of 2-8 °C, in the place protected from light. To store in the place, unavailable to children. List B. Period of validity. 3 years. Not to use after expiry date.


Issue conditions:

According to the recipe


Packaging:

On 2 ml of drug in ampoules from colourless glass. On 5 ampoules in a polystyrene strip packaging together with the application instruction will prevent in a cardboard box.



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