Kaltsy-D3 Nikomed (mint)

General characteristics. Structure:

Active a komponenty:kaltion a carbonate - 1250 mg (it is equivalent to elementary calcium - 500 mg)
колекальциферол (D3 vitamin) - 5 mkg (200 ME) in the form of a concentrate of a kolekaltsiferol of 2 mg.
 
Auxiliary components: sorbitol, mint flavoring additive, povidone, magnesium stearate, aspartame.
 
Description: Round, biconvex tablets without cover of white color with mint aroma. Can have small impregnations and uneven edges.

Pharmacological properties:

The combined drug regulating exchange of calcium and phosphorus in an organism (bones, teeth, nails, hair, muscles). Reduces a resorption (rassasyvaniye) and increases density of a bone tissue, compensating for the deficiency of calcium and D3 vitamin of an organism, it is necessary for a mineralization of teeth. Calcium participates in regulation of nerve conduction, muscular contractions and is a component of system of a blood coagulation.

Pharmakodinamichesky properties.

Vitamin D increases absorbability of calcium in intestines.

Use of calcium and D3 vitamin interferes with increase in production of parathyroid hormone (PTG) which is a stimulator of the raised bone resorption (washing away of calcium from bones).

Pharmacokinetic properties.

D3 vitamin is soaked up in a small intestine. Calcium is soaked up in the ionized form in proximal department of a small intestine by means of active, D-vitamin of the dependent transport mechanism.

Indications to use:

- Prevention and treatment of deficit of calcium and/or D3 vitamin.
- Prevention and complex therapy of osteoporosis (menopausal, senile, steroid, idiopathic, etc.).

Route of administration and doses:

Adult: at treatment of osteoporosis - on 1 tablet 2-3 times a day, for prevention of osteoporosis - on 1 tablet 2 times a day.

At deficit of calcium and vitamin D:
To adults and children 12 years - on 1 tablet 2 times a day are more senior.
To children from 5 to 12 years: on 1-2 tablets a day.
To children from 3rd to 5 years - a dosage according to recommendations of the doctor.

Tablets can be chewed or rassasyvat and accepted during food.

Features of use:

• Kaltsy-D3 Nikomed contains aspartame which in an organism is transformed to phenylalanine. Therefore the patients suffering from a fenilketonuriya should not accept drug.
• In order to avoid overdose, it is necessary to consider additional intake of D3 vitamin from other sources.
• Reception of the food stuffs containing oxalates (a sorrel, spinach) and phytin (grain) reduces absorbability of calcium therefore it is not necessary to accept Kaltsy-D3 Nikomed within two hours after reception of a sorrel, spinach, grain.
• Kaltsy-D3 Nikomed has to be used with care at the immobilized patients with osteoporosis in connection with risk of development of a hypercalcemia.

Side effects:

Allergic reactions, digestive tract dysfunction (locks or diarrhea, meteorism, nausea, abdominal pain), hypercalcemia and hypercalcuria (the increased content of calcium in blood or urine).

Interaction with other medicines:

• Activity of D3 vitamin can decrease at its simultaneous use with Phenytoinum or barbiturates.

• At simultaneous treatment by cardiac glycosides control of an ECG and clinical state since drugs of calcium can exponentiate therapeutic and toxic effects of cardiac glycosides is necessary.

• Drugs of calcium and D3 vitamin can increase absorption of tetracyclines from digestive tract. Therefore time interval between administration of drug of a tetracycline row and Kaltsy-D3 Nikomed has to be not less than 3 hours.

• For prevention of decrease in absorption of drugs of bisfosfonat or sodium fluoride, Nikomed is recommended to accept Kaltsy-D3 not earlier than in 2 hours after their reception.

• Glucocorticosteroids reduce absorbability of calcium therefore treatment by glucocorticosteroids can demand increase in a dose of Kaltsy-D3 Nikomed.

• Simultaneous treatment by drugs of Colestyraminum or purgatives on the basis of mineral or vegetable oil can reduce D3 vitamin absorption.

• At simultaneous use of diuretics of a thiazide row the risk of emergence of a hypercalcemia since they increase a canalicular reabsorption of calcium increases. Furosemide and other loopback diuretics, on the contrary, increase calcium removal by kidneys.

• At patients who at the same time accept cardiac glycosides and/or diuretics it is necessary to control concentration of calcium and creatinine in blood serum.

Contraindications:

• A hypercalcemia (the increased concentration of calcium in blood).
• A hypercalcuria (the increased content of calcium in urine).
• Nephrolithiasis.
• Vitamin D hypervitaminosis.
• Hypersensitivity to drug components.
• Heavy renal failure.
• Active form of tuberculosis.
• Sarcoidosis.

Drug in a dosage form - tablets is not applied at children aged up to 3 years.

Use with care: pregnancy, lactation period.

Use during pregnancy and during feeding by a breast

The daily dose should not exceed 1500 mg of calcium and 600 ME D3 vitamins.

The hypercalcemia developing against the background of overdose during pregnancy can cause defects of intellectual and physical development of the child.

Vitamin D and its metabolites can get into breast milk therefore it is necessary to consider intake of calcium and vitamin D of other sources at mother and the child. A hypercalcemia (the increased concentration of calcium in blood).

Hypercalcuria (the increased content of calcium in urine).

Overdose:

Symptoms: anorexia, thirst, polyuria, loss of appetite, dizziness, unconscious states, weakness, nausea, vomiting, hypercalcuria, hypercalcemia, hypercreatinemia. At prolonged use of excess doses calcification of vessels and fabrics.

Treatment: introduction to an organism of a large amount of liquid, use of loopback diuretics (for example, Furosemide), glucocorticosteroids, calcitonin, bisfosfonat.

In case of detection of signs of overdose ask for the help the doctor.

In case of development of clinical symptoms of overdose, it is necessary to define concentration of calcium and creatinine in blood. In case of the increased concentration of calcium or creatinine in blood serum it is necessary to lower a dose of drug or to temporarily stop treatment.

In case of the hypercalcuria exceeding 7,5 mmol/days (300 mg/days) it is necessary to reduce a dose or to stop reception.

Storage conditions:

Period of validity - 3 years. Not to use after a period of validity. To store a bottle densely closed at a temperature not above 25 °C in the dry place. To store in the place, unavailable to children!

Issue conditions:

Without recipe

Packaging:

Chewable tablets on 20, 50 or 100 tablets in the bottle from polyethylene of high density corked by the screw-on cover under which there is a ring for a separation of the condensing laying providing control of the first opening. A part of the label is attached to a bottle by a special adhesive tape which allows to raise the label. The application instruction in the form of the developing leaf is located under a mobile part of the label.