Artromed

General characteristics. Structure:

Active ingredients: glycosamine, chondroitin sulfate.

Pharmacological properties:

Pharmacodynamics. Stimulates regeneration of cartilaginous tissue. The glycosamine and chondroitin sulfate take part in synthesis of connecting fabric, promoting prevention of processes of destruction of a cartilage and stimulating fabric regeneration. Introduction of an exogenous glycosamine strengthens development of a cartilaginous matrix and provides nonspecific protection against chemical injury of a cartilage.

The glycosamine in the form of sulphatic salt is a predecessor a hexosemine, and sulfate-anion is necessary for synthesis of glikozaminoglikan. Other possible function of a glycosamine is protection of the injured cartilage against the metabolic destruction caused by NPVP and GKS and also own moderate antiinflammatory action. Chondroitin sulfate irrespective of whether it is soaked up in an intact form or in the form of separate components, serves as additional substrate for formation of a healthy cartilaginous matrix.

Stimulates formation of a gialuronon, synthesis of proteoglycans and collagen like II, and also protects гиалуронон from zymolysis (by suppression of activity of hyaluronidase) and from the damaging action of free radicals; maintains viscosity of synovial fluid, stimulates mechanisms of a reparation of a cartilage and suppresses activity of those enzymes which split a cartilage (elastase, hyaluronidase). At treatment of an osteoarthrosis facilitates symptoms of a disease and reduces the need for NPVP.

Pharmacokinetics. Glycosamine: bioavailability at oral administration — 25% (effect of "the first passing" through a liver). It is distributed in fabrics: the greatest concentration are found in a liver, kidneys and a joint cartilage. About 30% of the accepted dose are long persistirut in bone and muscular tissue. It is removed preferential with urine in not changed look; partially — with a stake. T1/2  is 68 h. Chondroitin sulfate: at intake once (or 2 times a day in a dose of 0,4 g) concentration in plasma sharply increases in a dose of 0,8 g for 24 h. Absolute bioavailability — 12%. About 10 and 20% of the accepted dose are absorbed in the form of high-molecular and low-molecular derivatives respectively. The seeming distribution volume — about 0,44 ml/g. It is metabolized by means of desulphonation. It is removed with urine. T1/2  — 310 min.

Indications to use:

Osteoarthrosis of the I-III St.

Route of administration and doses:

Inside, in 20 min. prior to food, washing down with 1 glass of water. Adults: on 2 capsules 2–3 times a day. Treatment duration — 1–2 months. If necessary the course of treatment is repeated.

Features of use:

At emergence of undesirable effects from a GIT the dose of drug should be reduced twice, and in the absence of improvement — to cancel drug.

In the absence of clinical effect after a medical course on 4 капс / days during 4 weeks should resolve an issue of specification of the diagnosis.

Side effects:

Glycosamine: often — dysfunction of a GIT (pain in epigastriums, a meteorism, diarrhea or a lock), dizziness, skin allergic reactions, a headache, an onychalgia and peripheral hypostases, drowsiness, sleeplessness, tachycardia.

Chondroitin: allergic reactions.

Interaction with other medicines:

Increases absorption of tetracyclines, reduces effect of semi-synthetic penicillin and a glycosamine. Drug is compatible to NPVP and GKS.

Contraindications:

Hypersensitivity, fenilketonuriya.

Overdose:

Symptoms: cases of overdose are unknown.

Treatment: gastric lavage, symptomatic therapy.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

On 10 capsules in each blister, on 3, 6 or 10 blisters together with the application instruction in cardboard packaging.