Elok

General characteristics. Structure:

Cream.
Active agent: a mometazona furoate - 1 mg.

Excipients: hexyleneglycol, water the purified, phosphoric acid (for installation рН), propylene glycol stearate, stearyl alcohol and a macrogoal цетостеарат (Tsetearet-20), titanium dioxide, starch aluminum octenylsuccinate, white beeswax, vaseline.

Ointment.
Active agent: a mometazona furoate - 1 mg.

Excipients: hexyleneglycol, water the purified, phosphoric acid (for establishment рН), propylene glycol stearate, white beeswax, vaseline.

Pharmacological properties:

Mometazona furoate - a synthetic glucocorticosteroid (GKS) possessing antiinflammatory, antipruritic and anti-exudative action. GKS induce release of the proteins inhibiting a phospholipase of A2 and known under the general name of a lipokortina which control biosynthesis of such mediators of an inflammation as prostaglandins and leukotrienes by braking of release of their common precursor of arachidonic acid.

Pharmacokinetics. Absorption of cream and ointment by Elok is insignificant. In 8 hours after drawing on the unimpaired skin (without occlusive bandage) in a system blood-groove about 0,4% of cream and 0,7% of ointment are found.

Indications to use:

The inflammatory phenomena and itch at the dermatosis which is giving in to glucocorticosteroid therapy.

Route of administration and doses:

Outwardly.
The thin layer of cream or ELOKOM ointment is applied on affected areas of skin once a day. Duration of a course of treatment is defined by its efficiency, and also portability the patient, existence and expressiveness of side effects.

Features of use:

When drawing on big sites of skin for a long time, especially at use of occlusive bandages, development of systemic action of GKS is possible. Considering it, patients have to be observed concerning function suppression signs гипоталамо - pituitary and adrenal system and development of a syndrome of Cushing.
It is necessary to avoid Elokom's hit in eyes.
The propylene glycol which is a part of drug can cause irritation in a site of application. In such cases it is necessary to stop Elokom's use and to appoint the corresponding treatment.
It is necessary to consider that GKS are capable to change displays of some diseases of skin that can complicate diagnosis. Besides, use of GKS can be the cause of a delay of healing of wounds. At long therapy of GKS the sudden termination of therapy can lead to development of a syndrome of the ricochet which is shown in the form of dermatitis with intensive erubescence and a burning sensation. Therefore after a long course of treatment drug withdrawal should be made gradually, for example passing to the intermittent scheme of treatment before completely to stop it.

Use in pediatrics.
Because children have a size of a ratio of surface area and body weight it is more, than at adults, children are subject to bigger risk of suppression of function гипоталамо - pituitary and adrenal system and development of a syndrome of Cushing at use of any GKS of local action. Long GKS can lead treatment of children to disturbances of their growth and development.
Children have to receive the minimum dose of drug sufficient for achievement of effect.

Side effects:

Seldom - irritation and a xeroderma, a burning sensation, an itch, a folliculitis, a hypertrichosis, acne rash, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of skin, accession of consecutive infection, signs of an atrophy of skin, a striya, a heat rash. Less than in 1% of cases — papulation, pustules.

At use of the GKS outside forms for a long time and/or for treatment of big sites of skin, or with use of occlusive bandages, especially children and teenagers, can have side effects characteristic of GKS of systemic action, including adrenal insufficiency and Cushing's syndrome.

Interaction with other medicines:

Any interaction of drugs by Elok cream and ointment with other medicines is not registered.

Contraindications:

Hypersensitivity to any component of drug or to GKS.
Pink eels, perioral dermatitis.
Bacterial, virus (Herpes simplex, chicken pox, Herpes zoster) or fungal infection of skin. Tuberculosis, syphilis.
Postvaccinal reactions.
Pregnancy (treatment of extensive sites of skin, prolonged treatment).
The lactation period (use in high doses or/and for a long time).

With care. Drawing on face skin and intertriginozny skin, use of occlusive bandages, and also treatment of big sites of skin and/or prolonged treatment (especially at children).

Use during pregnancy and a lactation. Safety of use of a mometazon of furoate during pregnancy and a lactation is not studied. GKS get through a placental barrier. It is necessary to avoid prolonged treatment and use of high doses during pregnancy in connection with threat of negative impact on fetation.

GKS are allocated with breast milk. In case use of GKS in high doses and/or is supposed for a long time, it is necessary to stop breastfeeding.

Overdose:

Symptoms: function oppression гипоталамо - pituitary and adrenal system, including secondary adrenal insufficiency.

Treatment: symptomatic, if necessary - correction of an electrolytic imbalance, drug withdrawal (at long therapy - gradual cancellation).

Storage conditions:

List B.
At a temperature not above 25 °C, in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

External use cream; ointment for external use. On 15 g or 30 g of cream or ointment in the aluminum tubas closed by a membrane and the screw-on plastic cap. On one tuba together with the application instruction in a cardboard pack.