Phencarolum

General characteristics. Structure:

Aktivony substance: hifenadina hydrochloride of 25 mg.

Excipients: potato starch - 14.5 mg, sucrose - 25 mg, calcium stearate - 0.5 mg.

Pharmacological properties:

Blocker histamine H1 receptors. Prevents development and facilitates the course of allergic reactions. Has antiallergic, anti-exudative and antipruritic effect, preventing development of an allergic inflammation in fabric. Weakens action of a histamine, reduces its influence on permeability of vessels (reducing permeability, renders antiedematous effect), reduces its bronkhospastichesky action and spazmogenny influence on smooth muscles of intestines, weakens hypotensive action of a histamine. Hifenadin reduces the maintenance of a histamine in fabrics (it is connected with ability to activate a diaminooxidase - the enzyme inactivating a histamine). At course treatment antihistaminic action of a hifenadin does not decrease. Possesses moderate antiserotoninovy action, shows weak m-holinoblokiruyushchuyu activity. Does not exert the oppressing impact on TsNS.

Pharmacokinetics.
Absorption and distribution. Hifenadin is quickly absorbed from a GIT, absorption makes 45%, and in 30 min. it is found in body tissues. Cmax in a blood plasma is reached in 1 h. Has low lipophilicity, badly gets through a blood-brain barrier. The highest concentration of active agent is found in a liver, a little smaller - in lungs and kidneys, the lowest - in a brain (less than 0.05% that explains lack of the oppressing influence on TsNS).

Metabolism and removal. Hifenadin is metabolized in a liver.
Metabolites are removed by kidneys and intestines. Through intestines not absorbed part of drug is removed.

Indications to use:

— pollinosis;
— acute and chronic small tortoiseshell;
— Quincke's disease;
— allergic rhinitis;
— dermatosis (including eczema, psoriasis, atopic dermatitis, skin itch).

Route of administration and doses:

Drug is accepted inside after food.
The scheme of a drug dosing matches at all indications to use. Expressiveness of allergic reaction, individual sensitivity of the patient, and also expressiveness of possible side effects can exert impact on dosing of a hifenadin.
The adult appoint 25-50 mg 3-4 Maximum daily dose - 200 mg. A course of treatment - 10-20 days. If necessary the course of treatment is repeated.
To children aged from 3 up to 7 years - on 10 mg 2; aged from 7 up to 12 years - on 10-15 mg 2-3; 12 years - on 25 mg 2-3 Course of treatment - are more senior 10-15 days.

Features of use:

With care it is necessary to appoint drug at gastrointestinal diseases, a liver and kidneys.
Lack of the expressed m-holinoblokiruyushchego of effect allows to appoint drug to patients to whom the antihistaminic drugs possessing m-holinoblokiruyushchey activity are contraindicated.
Influence on ability to driving of motor transport and to control of mechanisms
Persons whose profession demands the increased concentration of attention and speed of psychomotor reactions should define previously (by short-term appointment) whether renders sedation drug.

Side effects:

From the alimentary system: dryness of a mucous membrane of an oral cavity, nausea, vomiting.
From TsNS: drowsiness, headache.
Others: allergic reactions.

Interaction with other medicines:

Possessing weak m-holinoblokiruyushchimi properties, drug can reduce motility of a GIT that promotes increase in absorption of slowly absorbed drugs (for example, anticoagulants of indirect action - coumarins).

Contraindications:

— pregnancy;
— period of a lactation (breastfeeding);
— children's age up to 3 years (for this dosage form);
— deficit of invertase/isomaltase, intolerance of fructose, glyukozo/galaktozny malabsorption since drug contains sucrose;
— hypersensitivity to drug components.

Use of the drug PHENCAROLUM at pregnancy and feeding by a breast
It is not recommended to apply at pregnancy. In need of use during pregnancy it is necessary to weigh carefully a ratio of estimated advantage for mother and risk for a fruit.
In need of treatment by drug breastfeeding needs to be stopped.

Use for children
Drug is appointed to children at the age of 2 years and is more senior.

Overdose:

Symptoms: dryness of mucous membranes, headache, vomiting, abdominal pains and other symptoms of dyspepsia.
Treatment: gastric lavage, reception of absorbent carbon, performing symptomatic therapy.
At overdose the patient has to see a doctor.

Storage conditions:

Drug should be stored in the unavailable to children, dry, protected from light place.

Issue conditions:

Without recipe

Packaging:

Tablets of white or almost white color, round, ploskotsilindrichesky, with a facet.
10 - planimetric strip packagings (2) - packs cardboard.