Loperamide капс. 2 mg No. 20

General characteristics. Structure:

Active agent: hydrochloride loperamide (in terms of 100% substance) - 2 mg.

Excipients: lactose (sugar milk), microcrystallic cellulose, silicon dioxide colloid (aerosil), magnesium stearate capsule cover: case: gelatin, titanium dioxide, lid: gelatin, titanium dioxide, dye diamond blue, dye azoruby (dye Crimson), dye phloxine B.

Description: Solid gelatin capsules No. 3: the case of white color with a lid of blue color. Contents of capsules - powder of color, white or white with a yellowish shade. Pharmakoterapevtichesky group: antidiarrheal means.

Pharmacological properties:

Pharmacological properties. Loperamide, contacting opioid receptors of an intestinal wall (stimulation sincaline - and adrenergic neurons through a guanine nucleotides), reduces a tone and motility of smooth muscles of intestines (at the expense of inhibition of release of acetylcholine and prostaglandins). Slows down a peristaltics and increases time of passing of intestinal contents. Raises a tone of a proctal sphincter, promotes deduction of fecal masses and an urezheniye of desires to defecation. Action develops quickly and continues 4-6 h.

Pharmacokinetics. Absorption - 40%. Communication with proteins of plasma - 97%. An elimination half-life - 9-14 h. Does not get through a blood-brain barrier. It is almost completely metabolized in a liver by conjugation. It is removed preferential with bile and kidneys.

Indications to use:

Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, medicinal, beam; at change of a diet and qualitative structure of food, at disturbance of metabolism and absorption; as supportive application at diarrhea of infectious genesis). Regulation of a chair at patients from ileostomy.

Features of use:

At effect otsutstviye after 2 days of use of loperamide it is necessary to specify the diagnosis and to exclude infectious genesis of diarrhea. If at treatment locks or abdominal distention develop, loperamide should be cancelled. At patients with an abnormal liver function careful control of signs of toxic defeat of TsNS is necessary. During treatment of diarrhea it is necessary to make up for loss of liquid and electrolytes. During treatment it is necessary to be careful during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions. Form of release of the Capsule of 2 mg. On 10 capsules in a blister strip packaging. On 20 capsules in banks of light-protective glass or banks polymeric or bottles polymeric. Each can or a bottle or 1 or 2 blister strip packagings together with the application instruction are placed in a pack from a cardboard.

Side effects:

Headache, gastralgia, dryness in a mouth, allergic reactions (skin rash), drowsiness or sleeplessness, dizziness, intestinal colic, pain or discomfort in a stomach, nausea, vomiting, a lock, a meteorism. Seldom - an ischuria. Extremely seldom - intestinal impassability.

Contraindications:

Hypersensitivity to drug, a divertuculosis, intestinal impassability, ulcer colitis in an aggravation stage, diarrhea against the background of an acute pseudomembranous coloenteritis, in the form of monotherapy - dysentery and other infections of digestive tract: pregnancy (the I trimester), the lactation period, loperamide in capsules are not appointed to children up to 6 years. With care - a liver failure; The II-III trimester of pregnancy at a ratio risk/advantage. Route of administration and doses Inside. Adult at acute and chronic diarrhea originally appoint 2 capsules (4 mg), then on 1 capsule (2 mg) after each act of defecation in case of a liquid chair. The maximum daily dose - 8 capsules (16 mg). To children 6 years are more senior appoint on 1 capsule (2 mg) after each act of defecation in case of a liquid chair. The maximum daily dose - 3 capsules (6 mg). After normalization of a chair or in the absence of a chair more than 12 hours treatment by Loperamide should be stopped.

Overdose:

Symptoms: oppression of the central nervous system (stupor, lack of coordination, drowsiness, miosis, muscular hypertension, respiratory depression), intestinal impassability. Treatment: an antidote - Naloxonum; considering that duration of effect of loperamide is more, than at Naloxonum, perhaps repeated introduction of the last. Symptomatic treatment: absorbent carbon, gastric lavage, artificial ventilation of the lungs. Medical observation, at least, within 48 hours is necessary.

Storage conditions:

List B. To store in the dry place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity: 2 years. Not to apply after the expiry date specified on packaging.

Issue conditions:

Without recipe