Klaritromitsin, the tab. п / about 250 mg, 500 mg No. 5*2, 7*2

General characteristics. Structure:

Active agent: 1 tablet contains - a klaritromitsina in terms of 100% substance – 250 mg or 500 mg;

excipients: lactose, starch, silicon dioxide colloid, the talc purified magnesium stearate, titanium dioxide, a film cover of a gidroksipropilmetiltsellyuloza, the polyethyleneglycol 6000, talc purified dye yellow quinolinic Yellow Lake.

Pharmacological properties:

Antibacterial, bacteriostatic drug. Synthesis of protein due to linkng with a ribosome subunit oppresses. Klaritromitsin is highly active rather wide range of aerobic and anaerobic gram-positive and gram-negative microorganisms: Pasteurella multocid, Borellia burgdorferi, Mycobacterium (including Mycobacterium avium, Mycobacterium leprae, intracellulare, kansasii, fortuitum), Clostridium perfringens, Streptococcus agalactiae, Str. pyogenes, Str. viridans, Str. pneumoniae, Haemophilus influenzae (parainfluenzae), Neisseria gonorrhea, Listeria monocytogenes, Legionella pneumophila, Mycroplasma pneumoniae, Helicobacter (Campilobacter) pylori, Campilobacter jejuni, Chlamydia pneumoniae (trachomatis), Moraxella (Branhamella) catarrhalis, Bordella pertussis, Propionibacterium acnes, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii.

Indications to use:

Infections of upper parts of respiratory tracts (laryngitis, pharyngitis, tonsillitis, sinusitis), infections of lower parts of respiratory tracts (bronchitis, bacterial pneumonia, atypical pneumonia); infections of skin and soft tissues (folliculitis, furunculosis, impetigo, wound fever); infections the caused Mycobacterium avium, Helicobacter pylori, Chlamydia trachomatis, Ureaplasma urealyticum.

Route of administration and doses:

To adults and children, 12 years are more senior, appoint 250 mg 2 times a day for 7 days. At heavy infections – on 500 mg 2 times a day on an extent – 6 - 14 days. Patients of advanced age at normal function of a liver and kidneys have no need for dose adjustment. At patients with a renal failure at clearance of creatinine (UK) less than 30 ml/min. the maximum daily dose of drug makes 250 mg at infections easy and moderate severity; at heavy infections – 500 mg in 2 receptions. The maximum duration of a course treatment at patients of this group has to make no more than 14 days. The pill should be taken with food and to swallow whole, without chewing.

Features of use:

Klaritromitsin it is necessary to appoint with care the patient with disturbances of functions of a liver and/or kidneys, and also to patients of advanced age. In patients with a renal failure (at clearance of creatinine it is less than 30 ml/min.) the dose of drug should be reduced twice. The maximum duration of a course treatment at patients of this group has to make no more than 14 days.

Side effects:

Possible nausea, vomiting, pain in epigastric area, diarrhea, tranzitorny increase in level of hepatic transaminases in blood serum, a headache, allergic reactions (a skin rash).

Contraindications:

Hypersensitivity to drug or antibiotics of group of macroleads. Pregnancy and lactation. To children up to 12 years drug in the form of tablets is not appointed.

Issue conditions:

According to the recipe

Packaging:

Tablets, 500 mg (No. 5*2, No. 7*2), 250 mg (No. 10, No. 7*2)