Амизон® Max

General characteristics. Structure:

Active ingredient: амизон (энисамиум iodide);

1 capsule contains an amizon (an enisamium of iodide) of 0,5 g;

excipient: magnesium stearate.

Pharmacological properties:

Amizon – derivative isonicotinic acid. Shows the inhibiting influence on influenza viruses, has interferonogenny properties, increases resistance of an organism to viral infections, has antiinflammatory, febrifugal and analgetichesky effect.

Antiviral action of Amizon is connected with his direct influence on influenza virus hemagglutinins owing to what virion loses ability to join target cells for further replication.

Antiinflammatory action is result of stabilization of cellular and lizosomalny membranes, delays of degranulation of basophiles, antioxidant action, normalization of level of prostaglandins, cyclic nucleotides and energy balance in the inflammation center. Febrifugal properties of this means are caused by influence on the temperature-controlled centers of a brain. Analgesic effect of drug is carried out through a reticular formation of a brainstem.

Amizon increases persistent immunity by increase in level of endogenous interferon in a blood plasma by 3-4 time, a lysozyme and increase in an antiserum capacity to causative agents of infections, and also cellular immunity – due to stimulation of functional activity                    of T lymphocytes and macrophages. This means is the powerful inductor of endogenous interferon.

After oral administration Amizon quickly gets to blood, its maximum concentration in blood is observed in 2-2,5 hours after reception. Amizon and his metabolites long circulate in a circulatory bed (the elimination half-life makes 13,5-14 hours), is metabolized in a liver, but quickly brought out of fabrics (the elimination half-life makes 2-3 hours). It is brought out of an organism for 90-95% with urine in the form of metabolites.

Indications to use:

Treatment of flu and SARS.

Route of administration and doses:

Amizon Max accept inside after food, without chewing.

The adult appoint on 1 capsule 2-4 times a day for 5-7 days.

The maximum single dose – 1 g, daily – 2 g.

Features of use:

It is necessary to appoint carefully drug to patients with diseases of a thyroid gland especially at a hyperthyroidism.

Use during pregnancy or feeding by a breast. Drug is contraindicated for use in the first trimester of pregnancy. Use in the second and third trimester is possible only on doctor's orders. The drug uses given relatively to the women nursing no.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Administration of drug Amizon Max does not influence ability to manage motor transport and to work with other mechanisms.

Children. Drug in this dosage form to children is not used.

Side effects:

Allergic reactions: hypersensitivity reactions, including skin rashes, a small tortoiseshell, a Quincke's disease, an itch.

From system of digestion: dryness and bitterness in a mouth, swelled a mucous membrane of an oral cavity, hypersalivation, coloring of language in yellow color, nausea, vomiting, heartburn, an abdominal pain, weight in right hypochondrium, a diarrhea, abdominal distention.

From system of breath: an asthma, a burning sensation in a throat.

Others: headache, dizziness, weakness, fluctuation of arterial pressure.

Interaction with other medicines:

Amizon Max strengthens action antibacterial and immunomodulators. The combination of this drug with ascorbic acid and other vitamins is reasonable. Also Amizon Max it is possible to appoint along with use of recombinant interferon.

Contraindications:

Hypersensitivity to drugs of iodine and other components of drug. Existence of allergic reactions irrespective of the allergen nature in the anamnesis. Crushing organic lesions of a liver and kidneys.

Overdose:

About cases of overdose of Amizonom Max it was not reported. At overdose strengthening of manifestations of side reactions is possible: coloring of mucous membranes in brown color, reflex vomiting, abdominal pains and diarrhea. Development of hypostases, an erythema, ugrepodobny and violent rashes, fevers is possible.

Treatment: gastric lavage, symptomatic treatment.

Storage conditions:

Period of validity. 2 years. Not to use drug after the termination of the period of validity specified on packaging. To store in the dry, protected from light place at a temperature not over 25 ºС. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 10 capsules in the blister. On 1 blister in a pack.