Kandesartan-Nan

General characteristics. Structure:

Active ingredient: Tsileksetit 8 mg, 16 mg or 32 mg of a kandesartan.

Excipients: lactose monohydrate, starch corn, hydroxypropyl cellulose, croscarmellose sodium, macrogoal 8000, magnesium stearate.

Antihypertensive.

Pharmacological properties:

Pharmacodynamics. Kandesartan-Nan contains active agent of a kandesartan tsileksetit which concerns to group of antagonists of receptors of angiotensin II. This medicine weakens and expands blood vessels and, thus, helps to reduce blood pressure and facilitates pumping cardiac performance. The beginning of hypotensive action after reception of the first dose of drug usually develops within 2 hours. Efficiency of drug does not depend on age and a sex of patients.

Indications to use:

- treatment of the increased arterial pressure (hypertensia);

- treatment of heart failure and disturbance of systolic function of a left ventricle as additional therapy to APF inhibitors or at intolerance of APF inhibitors.

Route of administration and doses:

Always accept this drug strictly according to recommendations of the attending physician. A pill should be taken inside once a day irrespective of meal, without chewing and washing down with enough the cooled boiled water. Accept drug daily at the same time.

Arterial hypertension. The recommended dose of drug of Kandesartan-Nan makes 8 mg once a day. Your attending physician can raise a drug dose to 16 mg once a day or to 32 mg once a day if necessary.

To patients with diseases of a liver, kidneys or lost liquid owing to vomiting, diarrhea or reception of diuretics the attending physician can appoint lower initial dose of drug.

The anti-hypertensive effect of a kandesartan at patients of negroid race is expressed more weakly, than at persons of other races. Therefore reception of higher dose of drug can be required by such patients.

Heart failure. The recommended initial dose of drug of Kandesartan-Nan makes 4 mg once a day. Your attending physician can raise a drug dose by a dosage doubling every 2 week to achievement of a dose of 32 mg once a day.

Kandesartan-Nan can be applied together with other drugs to treatment of heart failure (APF inhibitors, beta-blockers, diuretics and cardiac glycosides). Your attending physician himself will appoint to you the suitable accompanying therapy.

Features of use:

Observe special care at administration of drug if you have any of the following states: heart diseases, a liver or kidneys, stay on a hemodialysis, recently executed renal transplantation, loss of liquid owing to vomiting or diarrhea, a disease of adrenal glands (Conn's syndrome - primary hyper aldosteronism), the lowered arterial pressure, earlier had stroke.

If you are pregnant, then report about it to your attending physician. Kandesartan-Nan cannot be accepted during pregnancy in connection with risk of disturbance of fetation.

If you planned surgery, then report to your attending physician or the stomatologist that you accept Kandesartan-Nan (combined use with some anesthetics can cause a sharp lowering of arterial pressure).

In the presence at you one of the listed diseases or states before administration of drug surely consult with the doctor.

Use for children. Safety and efficiency of use of a kandesartan for children and teenagers aged up to 18 years are not established. It is not necessary to apply Kandesartan-Nan to treatment of children.

Use at pregnancy and during feeding by a breast. If you believe that you are pregnant (or could become pregnant), report about it to your attending physician. If you plan pregnancy or are already pregnant, then the doctor will recommend to stop administration of drug of Kandesartan-Nan and will appoint to you other medicine. Use of drug of Kandesartan-Nan it is not recommended in the first trimester of pregnancy and it is contraindicated in the second and third trimesters of pregnancy.

Feeding by a breast. If you nurse or plan to begin feeding of the child with a breast, report about it to your attending physician. Kandesartan-Nan is not recommended to be applied at nursing mothers. At desire to continue breastfeeding, especially if the child is newborn or premature, the doctor will appoint to you other medicine.

Influence on ability to drive the car and potentially dangerous mechanisms. During treatment by Kandesartan-Nan Va's drug you can feel dizziness or weakness therefore it is necessary to be careful at control of motor transport and occupation other potentially dangerous types of activity demanding concentration of attention and speed of psychomotor reactions.

Important information on some components of drug of Kandesartan-Nan. Lactose is a part of this medicine. If your doctor told you that you have an intolerance of some sugars, then before use of this medicine you need to consult with the doctor.

Side effects:

Use of medicine of Kandesartan-Nan can be followed by development of side effects which are shown not at everyone. Nevertheless, you have to be informed on them.

Stop administration of drug of Kandesartan-Nan and immediately ask for medical care in case of development of any of the following allergic reactions:

• difficulty of breath with or without face edema, lips, a mouth, language and/or a throat;

• a face edema, lips, a mouth, language and/or a throat with swallowing difficulty;

• severe skin itch.

At administration of drug of Kandesartan-Nan decrease in level of leukocytes is possible that can lead to decrease in body resistance to infections. At increase in fatigue, development of infections or fever ask for medical care. Your attending physician will periodically direct you to blood test to estimate influence of drug of Kandesartan-Nan on a blood picture.

Other possible side effects. Frequent (arise at 1-10 people from 100): dizziness, vestibular dizziness, a headache, respiratory infections, low arterial pressure, increase in level of potassium in blood (especially in the presence of pathology of kidneys or heart failure), a renal failure (especially against the background of already existing pathology of kidneys or heart failure).

Very rare (arise less than at 1 of 10000 people): a face edema, lips, a mouth, language and/or a throat, decrease in level of erythrocytes or leukocytes in blood (increased fatigue, development of infections or fever are possible), skin rash, allergic rash, a skin itch, a dorsodynia, a joint pain and muscles, an abnormal liver function, including hepatitis (are possible raised by fatigue, yellowing of skin and/or scleras of eyes, grippopodobny symptoms), nausea, decrease in level of sodium in blood (at the expressed decrease in level of sodium weakness, breakdown and muscular spasms are possible), cough.

If any of the side effects specified in the instruction are aggravated, or you noticed any other side effects which are not specified in the instruction, report about it to your attending physician.

Interaction with other medicines:

Your attending physician has to be informed on all medicine which you take. Before reception of any medicine during treatment by Kandesartan-Nan's drug consult with the attending physician.

Kandesartan-Nan can exert impact on effect of some other drugs, as well as some drugs can exert impact on effect of drug of Kandesartan-Nan. You should inform the attending physician if you accept the following medicines:

• anti-hypertensive drugs, including APF inhibitors, such as enalapril, captopril, lisinopril or ramiprit;
• non-steroidal anti-inflammatory drugs (NPVS), including an ibuprofen, Naproxenum. diclofenac, целекоксиб, эторикоксиб, acetylsalicylic acid (in a dose more than 3 grams a day);
• the drugs of potassium or substitutes of salt containing potassium (means which can increase potassium level in blood serum);
• heparin (means, anticlotting);
• diuretics;
• lithium drugs (drugs for treatment of a mania or a depression).

Meal does not exert impact on hypotensive effect of a kandesartan.

Contraindications:

- hypersensitivity to a kandesartan to a tsileksetil or other components of drug;

- second and third trimesters of pregnancy;

- the expressed abnormal liver functions or disturbance of removal of bile from a gall bladder.

Overdose:

At reception bigger, than it is registered by the doctor, doses of medicine it is necessary to address immediately specialists for rendering timely medical care!

At overdose perhaps expressed lowering of arterial pressure, dizziness or a faint. It is necessary to lay the patient in horizontal position with the raised legs. To hold further events for instructions of the doctor.

Admission of the next administration of drug of Kandesartan-Nan. If you forgot to accept drug, then it is not necessary to compensate the admission by reception of a double dose, just accept a usual dose of drug.

Termination of administration of drug of Kandesartan-Nan. If you stop administration of drug of Kandesartan-Nan, then your arterial pressure can increase again. It is necessary to continue administration of drug even if you well feel. If you intend to stop administration of drug, then surely consult with the doctor.

At emergence of additional questions on use of this drug, consult to your attending physician or the druggist.

Storage conditions:

To store in the place protected from light and moisture at a temperature not over 25 ºС. List B. To store in the place, unavailable to children. Period of validity 2 years. 

Issue conditions:

According to the recipe

Packaging:

Tablets dosage of 8 mg: on 25 or 30 tablets in a blister strip packaging. 1 blister strip packaging with the instruction on a medical use place in a pack cardboard.

Tablets dosage of 16 mg: on 15 or 25 tablets in a blister strip packaging. 1 blister strip packaging on 25 tablets or 2 blister strip packagings on 15 tablets with the instruction on a medical use place in a pack cardboard.

Tablets dosage of 32 mg: on 10 tablets in a blister strip packaging. 3 blister strip packagings with the instruction on a medical use place in a pack cardboard.