D3 calcium CLASSIC

General characteristics. Structure:

Active ingredients: 500 mg of calcium (in the form of a carbonate), 5 mkg (200 ME) or 10 mkg (400 ME) of a kolekaltsiferol (in the form of granulate: колекальциферол, D, L - alpha tocopherol, triglycerides srednetsepochny, sucrose, acacias gum, starch corn, calcium phosphate, water).

Auxiliary components: Mannitolum, лактитол, dekstrata, sodium saccharinate (sodium saccharin), magnesium stearate, fragrance Yabloko or "orange".

The combined drug regulating exchange of calcium and phosphorus in an organism (bones, teeth, nails, hair, muscles).

Pharmacological properties:

The combined drug regulating exchange of calcium and phosphorus in an organism (bones, teeth, nails, hair, muscles). Reduces a resorption (rassasyvaniye) and increases density of a bone tissue, compensating for the deficiency of calcium and D3 vitamin of an organism, it is necessary for a mineralization of teeth. Calcium participates in regulation of nerve conduction, muscular contractions and is a component of system of a blood coagulation.

D3 vitamin increases absorbability of calcium in intestines.

Use of calcium and D3 vitamin interferes with increase in production of parathyroid hormone (PTG) which is a stimulator of the raised bone resorption (washing away of calcium from bones).

Pharmacokinetic properties. D3 vitamin is soaked up in a small bowel. Calcium is soaked up in the ionized form in proximal department of a small bowel by means of active, D3 vitamin of the dependent transport mechanism.

Indications to use:

For completion of deficit of calcium and D3 vitamin in an organism ׃

● at osteoporosis and its complications (a fracture of bones);

● during pregnancy and feeding by a breast;

● during intensive growth and development of children and teenagers;

● at a diet and unbalanced food.

Route of administration and doses:

For a dose of 500 mg + 200 ME.

Adult ׃

- in complex therapy of osteoporosis - on 1 tablet 2-3 times a day;

- for prevention of osteoporosis – on 1 tablet 2 times a day.

For completion of deficit of calcium and D3 vitamin. To adults and children 12 years - on 1 tablet 2 times a day in the morning and are more senior in the evening. To children from 5 to 12 years – on 1-2 tablet a day. To children from 3rd to 5 years – a dosage according to the recommendation of the doctor.

The tablet can be chewed or rassasyvat and accepted during food.

For a dose of 500 mg + 400 ME.

Adult:

- for course prevention of osteoporosis - on 2 tablets a day, one morning and one evening, it is preferential during food;

- in complex therapy of osteoporosis – on 1 tablet 2-3 times a day.

For completion of deficit of calcium and D3 vitamin. To adults and children 12 years - on 1 tablet a day are more senior.

The tablet can be chewed or rassasyvat and accepted during food. Before reception consult with the doctor.

Features of use:

● in order to avoid overdose, it is necessary to consider additional intake of D3 vitamin from other sources.

● Reception of the food stuffs containing oxalates (a sorrel, spinach) and phytin (grain) reduces absorbability of calcium therefore it is not necessary to accept D3 Calcium the CLASSIC within two hours after reception of a sorrel, spinach, grain.

Pregnancy and period of a lactation: The daily dose should not exceed 1500 mg of calcium and 600 ME D3 vitamins. The hypercalcemia developing against the background of overdose during pregnancy can cause defects of intellectual and physical development of the child.

D3 vitamin and its metabolites can get into breast milk therefore it is necessary to consider intake of calcium and D3 vitamin from other sources at mother and the child.

Side effects:

Allergic reactions, digestive tract dysfunction (locks or diarrhea, meteorism, nausea, abdominal pain), hypercalcemia and hypercalcuria (the increased content of calcium in blood or urine).

Interaction with other medicines:

● Activity of D3 vitamin can decrease at its simultaneous use with Phenytoinum or barbiturates.

● At simultaneous treatment by cardiac glycosides control of an ECG and clinical state since drugs of calcium can exponentiate therapeutic and toxic effects of cardiac glycosides is necessary.

● Drugs of calcium and D3 vitamin can increase absorption of tetracyclines from digestive tract. Therefore time interval between administration of drug of a tetracycline row and D3 Calcium the CLASSIC has to be not less than 3 hours.

● For prevention of decrease in absorption of drugs of bisfosfonat or sodium fluoride, the CLASSIC is recommended to accept D3 Calcium not earlier than in 2 hours after their reception.

● Glucocorticosteroids reduce absorbability of calcium therefore treatment by glucocorticosteroids can demand increase in a dose D3 Calcium the CLASSIC.

● Simultaneous treatment by drugs of Colestyraminum or purgatives on the basis of mineral or vegetable oil can reduce D3 vitamin absorption.

● At simultaneous use of diuretics of a thiazide row the risk of emergence of a hypercalcemia since they increase a canalicular reabsorption of calcium increases.

Furosemide and others "loopback diuretics", on the contrary, increase calcium removal by kidneys.

● At patients who at the same time accept cardiac glycosides and/or diuretics it is necessary to control concentration of calcium and creatinine in blood serum.

Contraindications:

● the Hypercalcemia (the increased concentration of calcium in blood);

● the Hypercalcuria (the increased content of calcium in urine);

● Nephrolithiasis;

● D3 vitamin Hypervitaminosis;

● Hypersensitivity to drug components;

● Heavy renal failure;

● Active form of tuberculosis;

● Sarcoidosis;

● Children's age up to 3 years (for a dose of 500 mg +200 ME);

● Children's age up to 12 years (for a dose of 500 mg +400 ME).

With care: A renal failure, a high-quality granulomatosis, pregnancy, the lactation period, reception of cardiac glycosides and thiazide diuretics, children's age (up to 12 years).

Overdose:

Overdose symptoms: anorexia, thirst, polyuria, loss of appetite, dizziness, unconscious states, weakness, nausea, vomiting, hypercalcuria, hypercalcemia, hypercreatinemia. At prolonged use of excess doses calcification of vessels and fabrics. Laboratory indicators at overdose: a hypercalcemia (Ca2 + in plasma about 2,6 mmol), a hypercalcuria.

In case of development of clinical symptoms of overdose, it is necessary to define concentration of calcium and creatinine in blood. In case of the increased concentration of calcium or creatinine in blood serum it is necessary to lower a dose of drug or to temporarily stop treatment.

In case of the hypercalcuria exceeding 7,5 mmol/days (300 mg/days) it is necessary to reduce a dose or to stop reception.

Treatment: a regidrotation, use of loopback diuretics (for example, furosemide), glucocorticosteroids, a calcitonin, bisfosfonat, in hard cases carrying out a hemodialysis.

In case of detection of signs of overdose ask for the help the doctor.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

Chewable tablets (apple) 500 mg + 200 ME and (orange) 500 mg + 400 ME. On 10, 15, 20, 30 tablets place in a plastic case for medicines or on 2, 4, 6, 8, 10 tablets place in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished or on 2, 4, 6, 8, 10 tablets place in planimetric bezjyacheykovy packaging from material film combined or from the material combined multilayer or from a foil of kashirovanny packaging. On 1, 2 plastic cases or on 1, 2, 3, 4, 5 planimetric packagings with the application instruction in a pack from a cardboard.