Бификол®

General characteristics. Structure:

Active ingredients: ^{not less than 107} live bifidobacteria and ^{not less than 107} live colibacilli.

Excipients: components of the protective environment of drying (gelatin; sugar or sucrose; milk).

Note: Maintenance of components of the protective environment of drying: edible gelatin, the K-13 or P-11 brand - from 1,5 to 3%, lumpy white sugar or sucrose - from 5 to 10%, the milk fat-free — raw materials - from 10 to 25%.

Drug represents the microbic mass of active strains of bifidobacteria (Bifidobacterium bifidum l) and colibacillus (Escherichia coli M-17) live antagonistic lyophilized in the environment of cultivation with addition of the protective sakharozo-zhelatino-milk environment of drying.

Pharmacological properties:

Pharmacodynamics. Medical action is caused by antagonistic activity of live bifidobacteria and colibacillus concerning pathogenic and opportunistic microorganisms, including shigellas, salmonellas, proteas, etc.

Drug has immunomodulatory and adjuvant activity at the expense of the bacterial antigens influencing development specific and nonspecific including local, protection factors; stimulates local reparative processes in intestines.

Indications to use:

Aftercare after acute intestinal infections in the presence of dysfunction of intestines, allocation of pathogenic bacteriums; treatment of chronic colitis of various etiology against the background of dysbacteriosis.

Route of administration and doses:

Drug is used orally from 6 months of age in 30 - 40 min. prior to food. Contents of a bottle are parted with the boiled water cooled to room temperature at the rate of 5 ml (one teaspoon) on one dose of drug. To carry out preparation of drug as follows: in a glass to pour a necessary amount of water (according to quantity of the doses specified on a bottle); to open a bottle, having removed a metal cap and a rubber bung; from a glass to transfer to a bottle a small amount of water (approximately to 2/3 volumes of a bottle) and to part contents, stirring up a bottle. Within 5 min. the homogeneous opaque suspension of beige or whitish-gray color is formed. To transfer all contents of a bottle to the same glass and to mix.

One teaspoon of the drug divorced thus makes 1 dose. Divorced drug is not subject to storage.

At an aftercare of convalescents after acute intestinal infections, dysfunctions of an unspecified etiology:
- children of 6 months to 1 g on 3 doses 2 times a day during 10-14 days;
- from 1 g up to 3 years — 5 doses 1-2 times a day during 10-14 days;
- also adult 5 doses 2-3 times a day during 14-21 days are more senior than 3 years.

Treatment of dysbacterioses, nonspecific and specific chronic colitis and coloenterites:
- children from 6 months to 1 year - on 3 doses 2 times a day during to 14 days;
- from 1 year to 3 years on 5 doses 2 times a day during 14-21 days;
- also adults on 5 doses 2-3 times a day during up to 3 weeks are more senior than 3 years.

The size of a daily dose and duration of treatment are determined by the doctor depending on weight, duration of a disease and expressiveness of dysbacteriosis. If necessary courses of treatment can be repeated, but not earlier than in 2 months after the end of treatment with preliminary control of a microbiocenosis of intestines.

Features of use:

Use at pregnancy and during breastfeeding. Safety of use of this medical supply at pregnancy and during feeding by a breast in the course of controlled clinical tests was not investigated.

Drug not marked, drug with the changed physical properties and availability of foreign impurity is unsuitable for use drug which integrity of packaging is broken.

Divorced drug is not subject to storage.

In case of the expressed reaction to drug (pain and burning in a stomach, nausea, vomiting, an unstable chair, a meteorism) temporary drug withdrawal (before the termination of the arisen symptoms) or the termination of treatment by Bifikol is reasonable (if above-mentioned symptoms arise repeatedly).

Influence on ability to manage vehicles, mechanisms. It was not studied.

Side effects:

In the course of treatment emergence of easy dispepsichesky frustration (discomfort in a stomach, abdominal distention, rumbling, an eructation) is possible which usually take place independently and do not demand drug withdrawal or symptomatic medicinal therapy.

Interaction with other medicines:

Simultaneous carrying out himio-and antibioticotherapias because of possible decrease in a therapeutic effectiveness of drug is not recommended.

Contraindications:

- ulcer colitis;
- deficit of invertase/isomaltase, lactase, intolerance of fructose, lactose, glyukozo-galaktozny malabsorption;
- children's age up to 6 months.

Overdose:

It is not registered.

Storage conditions:

Period of validity - 1 year. Drug is not subject to expired use. Storage conditions. According to the joint venture 3.3.2.1248-03 at a temperature not above 8 °C. To store in the place, unavailable to children. Transportation conditions. According to the joint venture 3.3.2.1248-03 at a temperature not above 8 °C.

Issue conditions:

Without recipe

Packaging:

Lyophilisate for preparation of suspension for intake. On 5 doses in a bottle. On 10 bottles in a pack with the application instruction.