Androgenetichesky alopecia

Description:

The Androgenetichesky alopecia (androgenic — it is wrong) represents the thinning of hair leading at men to baldness of parietal and frontal  areas, women — to a poredeniye have a hair in the field of the central hair parting of the head with distribution on its side surfaces.
Degree of manifestation of an androgenetichesky alopecia is characterized for men on Norwood's scale, for women — on Ludwig's scale.
Over 95% of all cases of baldness of men are the result of an androgenetichesky alopecia. Data on the frequency of manifestation of an androgenetichesky alopecia at women considerably disperse — from 20% to 90% of all cases of loss of hair that is connected with less noticeable and it is more difficult the diagnosed manifestation of this alopecia at women.

Symptoms of the Adrenogenetichesky alopecia:

Head hair remain, but they become thin, short, colourless (vellus hair) and cannot cover head skin any more — the bald head is formed. In 10-12 years after manifestation of an alopecia of the mouth of follicles grow with connecting fabric, and they cannot make even vellus hair any more.

Reasons of the Adrenogenetichesky alopecia:

The reasons of development of an androgenetichesky alopecia lie at the gene  level and consist in the damaging impact on hair follicles of an active form of male sex hormone of testosterone — the dihydrotestosterone which is formed under the influence of enzyme 5 - alpha reductase, being in hair follicles. Dihydrotestosterone, getting into cells of follicles, causes dystrophy of the last and, respectively, dystrophy of the hair made by them.

Treatment of the Adrenogenetichesky alopecia:

The modern medicine offers three approaches to fight against an androgenetichesky alopecia — medicinal therapy, laser therapy and transplantation of own hair.

From medicines today only two clinically proved the efficiency and safety at treatment of an androgenetichesky alopecia and got approval of the European medical agency (European Medicines Agency) and Management of quality control of products and drugs in the USA (U.S. Food and Drug Administration) — drug for topical use minoksidit (belongs to group of activators (openers) of potassium channels) (регейн in Europe, роугейн in the USA) and drug for internal use финастерид (a trademark Propecia — a finasterida of 1 mg), the last is recommended only to men. Drugs help not all and are not capable to cure an androgenetichesky alopecia but only give the chance to support an acceptable condition of hair while therapy is applied. After the termination of administration of drugs hair revert to the original state from several months to one year in time. Drug on the basis of natural trikosakharid (the trade name of Foltene of Pharm) enjoys wide popularity in Europe.

In in the second half of the 2000th in the CIS countries the production of drugs on the basis of activators of potassium channels whose action is similar to action of a minoksidil began: Minoxidin Alerana.

Low-intensive laser radiation also clinically proved the efficiency and is approved by the bodies for treatment of an androgenetichesky alopecia stated above by use in house conditions of a laser hairbrush. In the conditions of the medical centers more powerful clinical laser machines are used. Efficiency of a laser hairbrush is low. Clinical laser machines give significantly more expressed effect. As well as at medicinal therapy, the termination of laser therapy leads to degradation of hair to an initial state.

Transplantation of own hair is a surgical solution of a problem. The surgeon takes hair follicles from occipital and side departments of a surface of the head where follicles are not subject to dihydrotestosterone influence (androgennezavisimy zones), and transfers them to places of baldness. After change follicles continue to function in the usual mode, and the normal healthy hair remaining until the end of life grow from them. However not all candidates for transplantation of hair are suitable for this operation, and not always the long-term results of operation are satisfactory.

Now in the world active developments of perspective methods of a hair reconstruction at androgenetichesky baldness are conducted. The greatest expectations at the interested are connected by this question with technologies of cloning of hair and stimulations of growth of new hair.

The essence of the first technology consists in cloning of the hair follicles taken from androgennezavisimy zones of a surface of the head, with the subsequent implementation of the received clones to the grown bald sites of head skin by a special technique.

Developments of the second technology are based on an established fact that when healing wounds on sites of skin with hair the protein designated as Wnt which somehow promotes emergence on site of wound of new hair follicles becomes more active. The hair appearing from them normally pass all development cycles. Scientists consider that it is possible to force Wnt to make new follicles and on the unimpaired skin.