Generolon

General characteristics. Structure:

Active agent: minoksidit - 20,00 mg or 50,00 mg;

Excipients: ethanol (96%) - 571,00 / 243,00 mg, propylene glycol - 104,00 / 520,00 mg, water - to 1 ml.

Pharmacological properties:

Pharmacodynamics. At topical administration of a minoksidil stimulates growth of hair at persons with an androgenic alopecia (a poredeniye of hair, baldness). Improves microcirculation, stimulates transition of hair cells to the active growing phase, changes impact of androgens on hair sacks. Reduces education 5 - alpha дегидростерона (perhaps, indirectly) which plays an essential role in formation of baldness. The best effect renders at small prescription of a disease (no more than 10 years), young age of patients, a bald head in the field of a darkness no more than 10 cm, existence in the center of a bald head more than 100 vellus and terminal hair. Manifestation of signs of growth of hair is noted in 4 and more months of use of drug. The beginning and degree of manifestation of effect can fluctuate at different patients. 5% solution of drug stimulates growth of hair stronger, than 2% solution that was noted on increase in growth of vellus hair. After drug phase-out Generolop to growth of new hair stops, and within 3-4 months perhaps recovery of initial outward. The exact mechanism of effect of the drug Generalov® at treatment of an androgenic alopecia is unknown. Minoksidil is inefficient in case of the baldness caused by reception medicinal means, improper feeding (deficit of iron (Fe), vitamin A) as a result of hair dressing in "hard" hairstyles.

Pharmacokinetics. At external use minoksidit badly it is soaked up through the normal unimpaired skin: on average 1.5% (0,3 - 4,5%) of the general put dose come to a system blood stream. Influence of the accompanying skin diseases on absorption of a minoksidil is unknown. After phase-out of drug about 95% of the minoksidil which got to a system blood stream it is removed within 4 days. The profile of metabolic biotransformation of a minoksidil after external use of the drug Generolon® is completely not studied so far.
Minoksidil does not contact proteins of plasma and is brought by kidneys by means of glomerular filtering. Minoksidil does not get through a blood-brain barrier. It Ekskrstirutsya preferential with urine. Minoksidil and his metabolites are removed by means of a hemodialysis.

Indications to use:

Treatment of an androgenic alopecia (recovery of indumentum) and stabilization of process of a hair loss at men and women.

Route of administration and doses:

Outwardly.

Irrespective of the size of the processed site it is necessary to apply 1 ml of solution by means of the doser (7 pressing) 2 times a day on affected areas of a pilar part of the head, since the center of a problem zone. After use it is necessary to wash up hands. The total daily dose should not exceed 2 mg (the dose does not depend on the size of the struck area). To patients at whom is at use of 2% - го solution is not observed the satisfactory growth of hair, and patients for whom more rapid growth of hair is desirable can use 5% solution.

For men the drug Generolon® is most effective at a hair loss on the top, for women - at a hair loss in the field of a median hair parting.

The drug Generolon® is applied only on dry skin of a pilar part of the head. Solution does not demand washing off.

Emergence of the first signs of stimulation of growth of hair perhaps after drug use 2 times a day within 4 months or more. The beginning and degree of manifestation of growth of hair, and also quality of hair can fluctuate at different patients.

According to single messages within 3-4 months after the termination of treatment it is possible to expect recovery of initial outward. Treatment duration on average - about 1 year.

Preparation for use: To remove the screw-on cover and to fix the measured pump. On a tube from above of the pump to strengthen the extended nozzle for spraying. To press a raspylitelny nozzle 3-4 times in order that the pump was filled with solution then drug can be used.

Features of use:

Not to apply drug on other body parts.

The drug Generolon® is applied only on dry skin of a pilar part of the head after bathing or it is necessary to wait about 4 hours after putting drug before bathing. Do not allow the head to become wet earlier, than in 4 hours after putting drug.

It is recommended to wash hair at drug Generolon® use in the usual mode. During use the drug Generolon® it is possible to use hairspray and other conditioning agents behind hair. Before drawing means for care of hair it is necessary to apply at first the drug Generolon® and to wait until the processed site of skin completely dries up. There are no data that hair-dyeing, performance of a chemical wave or use of softeners for hair can reduce efficiency of drug. However, for prevention of possible irritation of a pilar part of the head it is necessary to be convinced that drug was washed completely away from hair and a pilar part of head skin before use of these chemical means.

Before an initiation of treatment the drug Generolon® patients have to undergo the general inspection including collecting and studying of the medical anamnesis. The doctor has to be convinced that skin of a pilar part of the head is healthy.

At emergence of system side effects or heavy skin reactions patients should cancel drug and to see a doctor.

Alcohol which can cause an inflammation and irritation of eyes is a part of the drug Generolon®. In case of hit of drug on sensitive surfaces (eyes, the angry skin, mucous membranes) it is necessary to wash out the site a large amount of cold water.

It is necessary to avoid inhalation of drug when spraying.

After use of drug it is necessary to wash up hands carefully.

Side effects:

Local side effects:
The most often found side effect is dermatitis of a pilar part of the head. More expressed dermatitis cases which are shown in the form of reddening, a peeling and an inflammation are less often observed. The head itch, allergic contact dermatitis, a folliculitis, a hypertrichosis (undesirable growth of hair on a body, including growth of hair in the person at women), seborrhea is in rare instances noted.

Use of a minoksidil can cause strengthening of a hair loss upon transition from a resting phase to a growth phase of hair, at the same time old hair drop out and on their place new grow. This temporary phenomenon is usually observed 2-6 weeks later after an initiation of treatment and gradually, within 2 next weeks, stops (emergence of the first signs of action of a minoksidil).

System side effects (at an accidental proglatyvaniye of drug):
Dermatological diseases: неспсцифическис allergic reactions (skin rash, small tortoiseshell), face edema.
Respiratory system: short wind, allergic rhinitis.

Nervous system: headache, dizziness, вертиго, neuritis.

Cardiovascular system: thorax pain, fluctuations of arterial pressure, cardiopalmus, change of a rhythm of cordial reductions, hypostases.

Interaction with other medicines:

There is a theoretical opportunity (clinical confirmation is absent) strengthenings of an ortostata of chesky hypotension at patients. receiving the accompanying treatment by peripheral vasodilators. It is impossible to exclude very slight increase of maintenance of a minoksidil in blood of the patients having arterial hypertension and accepting minoksidit inside in case of simultaneous use of the drug Generolon® though the corresponding clinical trials were not conducted. It is established that minoksidit for external use can interact with some medicines for external use. Simultaneous use of solution of a minoksidil for the external use and cream containing betamethasone (0,05%) leads to decrease in system absorption of a minoksidil. Simultaneous use of the cream containing третиноин (0,05%). leads to the increased absorption of a minoksidil. Simultaneous drawing on skin of a minoksidil and drugs for external use, such as третиноин and дитранол which cause change of protective functions of skin can lead to increase in absorption of a minoksidil.

Contraindications:

Hypersensitivity to a minoksidil or other components of drug; the age is younger than 18 years; disturbance of integrity of integuments, dermatosis of a pilar part of the head.

With care
Advanced age - is more senior than 65 years.

Use at pregnancy and in the period of chest feeding
It is not necessary to use drug at pregnancy and feeding by a breast.

Overdose:

Accidental intake of the drug Генеролон& can cause the system side effects caused by vasodilating properties of a minoksidil (5 ml of 2% - го solution contain 100 mg of a minoksidil - the maximum recommended dose for adults at intake at treatment of arterial hypertension; 5 ml of 5% - го solution contain 250 mg of a minoksidil, that is the dose by 2,5 times exceeding the maximum recommended daily dose for adults at intake at treatment of arterial hypertension). 11riznaki overdoses: liquid delay, lowering of arterial pressure, tachycardia. Treatment: for elimination of a delay of liquid if necessary diuretics can be appointed; for treatment of tachycardia - beta адрен about locators. For treatment of a ginotenziya it is necessary to enter intravenously 0.9% chloride sodium solution. It is not necessary to appoint simiatomimetichesky means, for example. норэпинсфрин and эпинсфрин, having the excessive cardiostimulating activity.

Storage conditions:

At a temperature not above 25 °C. To store in the place, unavailable to children!

Issue conditions:

Without recipe

Packaging:

Spray for external use of 2% and 5%.

60 ml of solution in a plastic bottle of white color. The bottle is closed the screwing-up plastic cover of white color; complete with the plastic measured pump and a nozzle for spraying in a protective bag. 1 bottle together with the application instruction, the plastic measured pump and a nozzle for spraying in a protective bag is placed in a cardboard pack.