Grippostad

Grippostad – the combined drug with the febrifugal and anesthetizing action.

Form of release and structure

Dosage form – powder for preparation of peroral solution: homogeneous, from white till yellowish color, possesses a characteristic smell of a lemon (on 5 g in the laminated packages from aluminum foil, 5 packages in a pack cardboard).

Active ingredients in 1 package:

• Paracetamol – 600 mg;
• Ascorbic acid – 50 mg.

Additional substances: citric acid anhydrous, silicon dioxide colloid anhydrous, ethyl cellulose, sucrose, aspartame, fragrance lemon.

Indications to use

• Weak and moderate pain syndrome: headache, migraine, neuralgia, mialgiya, arthralgia, альгодисменорея, dentagra;
• The feverish syndrome caused by catarrhal diseases.

Contraindications

Absolute:

• Fenilketonuriya;
• Bleeding in digestive tract;
• Deficit glyukozo-6-fosfatdegidrogenazy;
• Diseases of system of a hemopoiesis (thrombocytopenia, anemia, leukopenia);
• The expressed abnormal liver functions, kidneys;
• Portal hypertensia (increase in pressure of blood in a portal vein);
• The children's age up to 12 years or body weight is less than 40 kg;
• Hypersensitivity to drug components.

Relative:

• Rotor syndrome;
• Viral hepatitis;
• Alcoholic damage of a liver;
• Gilbert's syndrome;
• Abnormal liver function and kidneys;
• Syndrome Cudgel Johnson;
• Advanced age;
• Simultaneous use of the drugs containing paracetamol.

Researches on an occasion of safety of use of a combination of paracetamol with ascorbic acid at pregnant women and the nursing women were not conducted in this connection it is not possible to estimate a ratio of advantage and risk. For this reason during these periods use of drug is not recommended.

Route of administration and dosage

Grippostad accept inside. Just before reception contents of a bag are poured out in a glass and filled in with necessary amount of hot water, mixed and at once drink warm drink. In case of administration of drug after food the delay of the beginning of its action is possible.

Grippostad's dose (by paracetamol) is determined depending on age and the body weight of the patient. An average single dose – 10-15 mg/kg (1 bag). The maximum daily dose – 60 mg/kg: for patients with body weight not less than 51 kg – 4 bags, for patients weighing 40-50 kg – 3 bags. An interval between receptions – 6-8 hours.

If the patient at the same time accepts other drugs containing paracetamol it is necessary to be guided by the most admissible daily doses of paracetamol which are defined with the patient's weight:

• 40-50 kg – 2000 mg;
• 51-65 kg – 3000 mg;
• More than 66 kg – 4000 mg.

Patients with a heavy renal failure have to accept drug not less than with 8-hour intervals.

Patients with Gilbert's syndrome, diseases of kidneys or a liver need to lower a dose or to increase an interval between receptions.

Without recommendation of the doctor to accept Grippostad no more than 3 days are possible.

Side effects

• From the alimentary system: epigastric pain, nausea;
• Allergic reactions: urticaria, itch, skin rash, Quincke's disease;
• From system of a hemopoiesis: agranulocytosis, thrombocytopenia, anemia.

At prolonged use of drug in high doses hemopoiesis disturbance, a nephrotic and hepatotoxic action is possible.

Special instructions

Patients with a diabetes mellitus have to consider the content of sucrose in drug: in 1 bag – nearly 3,8 g (about 0,38 grain units).

Grippostad can distort indicators of laboratory researches at quantitative definition of uric acid and glucose in a blood plasma.

During treatment it is recommended to refrain from alcohol intake.

Drug does not exert a negative impact on attention and speed of reactions therefore it can be applied by the drivers of vehicles and patients occupied on potentially dangerous productions.

Medicinal interaction

• Diflunisal: plasma concentration of paracetamol increases by 50% and, as a result, risk of development of a hepatotoxic;
• Miyelotoksichny means: manifestations of a gematotoksichnost of drug amplify;
• Inhibitors of microsomal enzymes of a liver (for example, Cimetidinum): the risk of a hepatotoxic action of drug decreases;
• Ethanol: a paracetamol hepatotoxic, risk of development of acute pancreatitis amplifies;
• Uricosuric means: their efficiency decreases;
• Chloramphenicol: its toxicity amplifies;
• Metoclopramidum: absorbability of paracetamol increases;
• The drugs which are slowing down gastric emptying (for example, bromide, пропантелин): absorbability of paracetamol decreases;
• Indirect anticoagulants: their action amplifies;
• Inductors of microsomal enzymes of a liver (ethanol, Phenytoinum, barbiturates, phenylbutazone, rifampicin, tricyclic antidepressants): the probability of development of heavy intoxications even increases at small overdose.

Along with Grippostad it is contraindicated to use other drugs containing paracetamol, other non-narcotic analgesics, non-steroidal anti-inflammatory drugs (for example, acetylsalicylic acid, metamizole sodium, an ibuprofen), antiepileptic means, barbiturates, chloramphenicol, rifampicin.

In case of prolonged simultaneous use of paracetamol with other non-steroidal anti-inflammatory drugs the risk of development of a renal papillary necrosis, analgetic nephropathy, end-stage of a renal failure increases.

At prolonged use of high doses of paracetamol along with salicylates the risk of development of cancer of bladder or kidney increases.

Terms and storage conditions

To store at a temperature up to 30 ºС in the place, unavailable to children.

Period of validity – 5 years.