DE   EN   ES   FR   IT   PT Medicines Antiviral means. Giporamin


Препарат Гипорамин. ЗАО "Фармцентр Вилар” Россия

General characteristics. Structure:

In medical practice apply:
– Tablets сублингвальные:гипорамин extract dry – 0,02 g, excipients (refined sugar, cocoa powder, vanillin, sodium carboxymethylcellulose, calcium stearate) – before receiving a tablet weighing 0,6 g.
– Giporamin лиофилизированный:гипорамин lyophilized – 0,02 g.
– Ointment гипораминовая:гипорамин – 0,5 g, excipients (vanillin, vaseline, the twin-80 medical, emulsifier No. 1, oil eucalyptus, нипагин), the water purified – to 100,0 g.
– Suppositories ректальные:гипорамин – 0,05 g, a liquid paraffin, a basis for receiving suppositories (solid fat type A) – enough for receiving suppository weighing from 2,2 to 2,6 g.
– Suppositories вагинальные:гипорамин – 0,05 g, a liquid paraffin, a basis for suppositories (solid fat type A) – enough for receiving suppository weighing from 2,2 to 2,6 g.
– Suppositories for детей:гипорамин – 0,03 g, a liquid paraffin, a basis for suppositories (solid fat type A) – enough for receiving suppository weighing from 1,2 to 1,4 g.

Pharmacological properties:

Giporamin has the expressed antiviral activity concerning various strains of influenza viruses And yes In, adenoviruses, paramyxoviruses, viruses of a herpes simplex, shingles, cytomegaloviruses, a respiratory and syncytial virus, human immunodeficiency viruses (HIV infection). The inhibiting effect of a giporamin on a reproduction of viruses is shown at early stages of their development. The inhibiting effect on a virus neuraminidase is the cornerstone of the mechanism of action of a giporamin. Giporamin induces products of interferon in blood cells in experiences of in vitro and increases the content of interferon in blood of patients.
Drug in experiences of in vitro has also moderate antimicrobic effect concerning gram-positive and gram-negative bacteria, tubercular mycobacteria, Candida, some mitselialny mushrooms.
Giporamin малотоксичен. Has no allergenic, mutagen, teratogenic and cancerogenic properties, does not exert impact on the immune status of an organism.

Indications to use:

Giporamin apply at adults and children (aged from 2 months and is more senior) as treatment-and-prophylactic cure for flu (And yes In), a parainfluenza, respiratory and syncytial, adenoviral and other acute respiratory viral infections; the quinsies proceeding against the background of acute respiratory viral diseases and which are followed by rhinitises; at acute and recurrent forms of a herpes simplex of extragenital and genital localization, at shingles, chicken pox and a Cytomegaloviral infection and other infections caused by viruses, sensitive to drug.

Route of administration and doses:

Giporamin appoint in perhaps early terms of a disease. The highest medical effect is reached, at a combination of dosage forms of a giporamin of all-resorptive and local action.

At influenzal, adenoviral, respiratory and syncytial or other viral upper respiratory tract infection appoint: sublingual tablets on 0,02 g; suppositories on 0,05 g (adult) and suppositories on 0,03 g (children); lyophilized гипорамин 0,02 g which is used in the form of the aqueous solution prepared for ex tempore by addition in a bottle of the sterile distilled water of 10 ml (for receiving 0,2% of solution) or 20 ml (for receiving 0,1% of solution).

Sublingual tablets use for sanitation of an oral cavity for what they hold in a mouth to their full rassasyvaniye. At the same time the adult appoint on 1 tablet of 4-6 times a day, to children 12 years – on 1 tablet 3-4 times a day, to children from 3 to 12 years – on 1/2-1 tablet 2-4 times a day, depending on age are more senior. To children is younger than three years sublingual tablets do not apply.
Suppositories on 0,05 g for adults and on 0,03 g for children appoint per rectum as a dosage form of all-resorptive action 1-2 times a day depending on weight of process (existence of pneumonia, a hyperthermia and so forth). To children 3 years treatment by suppositories are younger carry out 1 time a day without sublingual tablets.

It is inhalation гипорамин enter by means of various inhalation devices (U-1, UZI-70, AI-1i other): adult – 0,2% aqueous solution to 10 ml on inhalation; to children – 0,1% aqueous solution: advanced age – to 10 ml on inhalation, to children of younger age – to 5 ml on inhalation.

In the presence of rhinitis 3-4 times a day, to children – 0,1% solution from 2 to 4 drops (depending on age) 2-3 times a day dig in in each nasal course adult 0,2% solution of 4-6 drops.
Treatment duration – at flu not less than 3 days. At a parainfluenza, RS-virusnykh, adenoviral, mikst-infections and other SARS – not less than 5 days.
For individual prevention during the outbreak of flu use sublingual tablets of a giporamin, per rectum suppositories and drops in a nose according to the same schemes.

At chicken pox, shingles, herpesviridae and Cytomegaloviral infections, and also other virus defeats of integuments and mucous membranes apply: sublingual tablets on 0,02 g; ointment of 0,5%; suppositories rectal and vaginal on 0,05 g (for adults); suppositories on 0,03 g (for children). Sublingual tablets are appointed to adults and children 12 years on 1 tablet of 4-6 times a day are more senior, children are 6-12 years old – on 1 tablet 3-4 times a day, children are 3-6 years old – on 1/2 tablets 2-4 times a day, to children 3 years of a tablet are younger do not appoint. Ointment of 0,5% inflict on the centers defeats of 4-6 times a day. As all-resorptive antiviral means at the same time at all forms of a disease appoint suppositories with giporaminy per rectum to 3 times a day: the adult – on 0,05 g and children 3 years – on 0,03 g are more senior. To children 3 years are younger suppositories on 0,03 g apply 1 time a day. At genital herpes in addition enter suppositories intravaginalno 1-2 times a day: the adult – on 0,05 g, children – on 0,03 g. Duration of use depends on weight of process and makes at easy forms of a disease of 3-10 days. At severe and recurrent forms of a disease the minimum course of treatment 2-3 weeks. Repeated courses of treatment are reasonable.

In the conditions of immunodepressive therapy, at postoperative patients, in risk groups, etc., гипорамин it is reasonable to apply to the prevention of development of virus complications. At the same time гипорамин apply to prevention of herpesviridae diseases and TsMV-of an infection in the form of sublingual tablets 0:02 g 3 times a day and/or per rectum suppositories 2 times a day, within 5-7 days.

Features of use:

1 tablet contains 0,5299 g of sugar of lump sugar. A sick diabetes mellitus to accept after consultation with the doctor.

Side effects:

At prolonged use in the doses exceeding specified in the instruction increase in coagulability of blood is possible.

Interaction with other medicines:

It is not revealed.


Individual intolerance.


When using drug in the form of sublingual tablets, ointment or suppositories intoxication was not observed.
Use of aqueous solutions in concentration higher than 0,2% can cause irritation of a mucous membrane of a nasal cavity.

Storage conditions:

Sublingual tablets and lyophilized гипорамин store in the dry, protected from light place, at a temperature of 15-25 °C.
Ointment and suppositories – in the cool, protected from light place.
Store in the places unavailable to children.

Issue conditions:

Without recipe


- Sublingual tablets on 0,02 g on 10, 20 or 30 tablets in a blister strip packaging or on 25 tablets in glass jars, dark glass.
- Lyophilized гипорамин on 0,02 g sterile in bottles.
- Ointment of giporaminovy 0,5% on 10 and 20 g in banks and tubas.
- Suppositories rectal and vaginal with giporaminy on 0,05 g in a blister strip packaging.
- Suppositories with giporaminy on 0,03 children in a blister strip packaging.

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