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Tropical pulmonary eosinophilia


Tropical pulmonary eosinophilia, or Vayngarten's syndrome (Latin eosinophilia tropica, English Weingarten's syndrome) — the tropical disease caused by hit in an organism of some types of nematodes, tape-worms or mites. It is characterized by a sharp eosinophilia, spastic bronchitis and focal infiltrative changes in lungs. The disease was described for the first time in the 1940th years by the American medical officer of R. J. Weingarten.

Symptoms of the Tropical pulmonary eosinophilia:

The main symptoms of helminthosis — fits of coughing and suffocation, as a rule, at night, the dry cough, an asthma and goose breathing which is especially expressed at night, an indisposition, appetite loss, weight loss. Persons at the age of 20-40 years get sick usually, men are ill 4 times more often than women. At an aggravation in lungs dry and wet rattles are listened. At children, unlike adults, lymph nodes and a liver often increase. Subfebrile temperature, increase in lymph nodes and the expressed eosinophilia (over 3000 in мкл).
Clinical manifestations are caused by inflammatory and allergic reaction on settled in easy parasites. In certain cases microfilarias are late in bodies of reticuloendothelial system that conducts to a hepatomegalia, a splenomegaly, increase in lymph nodes. The pneumosclerosis, respiratory insufficiency can develop.
The disease is characterized by cough, fervescence, the general weakness, weight loss, sometimes suffocation attacks. In blood tests are defined a leukocytosis (to 50×109 cells/l) and very high eosinophilia (80 — 90%). At radiological inspection in lungs multiple small shadows are found that reminds a picture of miliary tuberculosis. Pulmonary infiltrates remain long, sometimes within several months. The caption of cold agglutinins, often positive Wassermann reaction is raised. The current is long, with periodic aggravations.

Reasons of the Tropical pulmonary eosinophilia:

The tropical pulmonary eosinophilia is caused by activators of filariases Wuchereria bancrofti, Brugia malayi, etc. Brugia spp. Ascarids, ankylostomas, toksokara, эхинококкок and strongilida can also cause a syndrome.
Vayngarten's syndrome can arise also at infection with larvae or adult individuals of mites of Tyroglophus or Tarsonemus.

Treatment of the Tropical pulmonary eosinophilia:

Appoint the internal use of a dietilkarbamazin (4 — 6 mg to weight kg a day within 14 days).

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