Ksidifon

Ksidifon – the medicine regulating phosphorus-calcium exchange in an organism.

Form of release and structure

Ksidifon is issued in the form of 20% of solution for preparation of 2% of solution for oral administration: without color and a smell (in bottles on 50 or 100 ml, in polyethylene tanks on 100 and 250 ml).

Is a part of 10 ml of solution:

• Active ingredient: etidronovy acid (a dihydrate of a gidroksietilidendifosfonat of potassium) – 2 g;
• Auxiliary components: sodium hydroxide, the purified water.

Indications to use

Ksidifon's solution as the means regulating exchange of calcium at children and adults is appointed at the following states / diseases:

• Urolithiasis and other diseases of kidneys;
• Hypervitaminosis of D;
• Osteoporosis (for treatment and prevention);
• Hyperparathyreosis (fibrous and cystous osteitis) and the accompanying intersticial nephrite;
• Pseudorheumatism (for the prevention of development of osteoporosis and osteosinging at a long immobilization, increases in mass of a bone tissue at secondary osteoporosis).

Also drug is appointed in the presence of the following indications:

• Acceleration of removal from an organism of excess content of heavy metals: antimony, tin, lead, strontium, silicon;
• Stabilization of membranes of immunocompetent cells at adults at bronchial asthma of an easy and medium-weight current (along with other drugs);
• Prevention of osteoporosis at adults at hormonedependent bronchial asthma (along with other drugs).

Contraindications

• Hypocalcemia;
• Pregnancy and period of chest feeding;
• Hypersensitivity to drug components.

At a chronic coloenteritis Ksidifon appoint with care.

Route of administration and dosage

Ksidifon it is necessary to accept inside, it is desirable – in 30 minutes prior to meal.

Before use it is necessary to add 9 parts of the water (distilled or boiled) to 1 part of basic 20% of solution. Solution after cultivation needs to be stored in the refrigerator.

The recommended mode of dosing (single dose):

• Adults and children of 10 years: 300 mg (1 tablespoon);
• Children of 3-10 years: 200 mg (1 dessertspoon);
• Children up to 3 years: 10 mg/kg of body weight (1 teaspoon).

Frequency rate of reception – 2-3 times a day.

Duration of primary medical course – 14 days. At a crystalluria and concrements in kidneys carrying out 5-6 bucketed courses 21 days for 1-2 years is shown. For prevention of a recurrence of formation of stones Ksidifon appoint a course lasting from 2 up to 6 months.

At osteoporosis (treatment and prevention) drug is appointed on 5-7 mg/kg for 2-3 months. Repeatedly courses are conducted with a break by 1-2 months.

At trabecular osteoporosis and osteosinging against the background of a pseudorheumatism Ksidifon it is necessary to accept not less than a year. A daily dose – 5-10 mg/kg of body weight (in 2 receptions). Along with it it is recommended to eat food rich with calcium salts, (there correspond 500 ml of milk), or, at impossibility for any reasons of observance of this condition, to accept 1500 mg of a gluconate of calcium a day.

At chronic intoxications heavy metals and to the patients living in ecologically adverse conditions on heavy metals, Ksidifon is recommended to accept from 7 to 10 days of every month in a daily dose of 10 mg/kg of body weight.

At bronchial asthma Ksidifon appoint along with other drugs for treatment of patients for 16 years, therapy duration – is no more than 30 days.

Side effects

• Metabolism: rakhitopodobny effect and a hypomagnesiemia at a long course of reception of solution in high doses (with the preventive purpose use in the minimum doses of medicines with the content of magnesium and periodic reception of therapeutic doses of vitamin D is recommended);
• Alimentary system: in some cases the laxative effect can be observed (the daily dose can be divided on bigger, than it is recommended in instructions, number of receptions);
• Others: change of peroxide oxidation of lipids (passes at a concomitant use with vitamin E: once a day in a single dose of 3-5 drops of 5% of Solutio oleosa).

Special instructions

At reduced function of kidneys the mode of dosing of Ksidifon needs to be adjusted.

During therapy it is necessary to receive calcium and vitamin D in enough.

Medicinal interaction

Data on Ksidifon's interaction with other drugs are not submitted.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature up to 25 °C.

Period of validity – 3 years.

The prepared solution can be accepted for 1 month on condition of its storage in the refrigerator.