KAPRONAT PREGNENOLDIONE
Producer: CIAO Biofarm Ukraine
Code of automatic telephone exchange: G03D A03
Release form: Liquid dosage forms. Solution for injections.
General characteristics. Structure:
Active ingredient: 1 ml contains pregnenoldione of a kapronat 125 mg;
excipients: benzyl benzoate, olive oil.
Main physical and chemical properties: transparent oily liquid from light yellow till golden-yellow color.
Pharmacological properties:
Pharmakodikamika. Pregnenoldione капронат represents a synthetic analog of hormone of a yellow body. Also, as well as progesterone, causes transition of a mucous membrane of a uterus from a phase of the proliferation caused by follicular hormone in a secretory phase, and after fertilization promotes its transition to a state necessary for development of an oospore; reduces excitability and contractility of muscles of a uterus and pipes. After a one-time injection action remains from 7 to 14 days.
Pharmacokinetics. It was not studied.
Indications to use:
The usual or menacing abortion, primary and secondary amenorrhea, polymenorrhea, dysfunctional uterine bleedings (for normalization of a menstrual cycle), uterus cancer, a breast cancer.
Route of administration and doses:
Enter intramusculary.
At the usual or menacing abortion – 125-250 mg once a week during the first half of pregnancy.
At primary or secondary amenorrhea – directly after oestrogenic therapy of 250 mg once or in two steps.
At a polymenorrhea – 65-125 mg approximately for 20-22 day of a cycle.
Features of use:
With care apply at patients with cardiovascular diseases, abnormal liver functions and kidneys, a diabetes mellitus, bronchial asthma, epilepsy, migraine, a depression.
Side effects:
From endocrine system: increase in body weight, pain and tension in mammary glands, irregular uterine bleedings; seldom at prolonged use – decrease in a libido.
From TsNS: headache, depression.
From cardiovascular system: increase in the ABP.
From the alimentary system: abnormal liver function, jaundice, nausea, vomiting.
From a metabolism: hypostases.
Interaction with other medicines:
At simultaneous use with barbiturates effect of pregnenoldione decreases.
Contraindications:
Second half of pregnancy. Hypersensitivity to drug components, tachycardia, holitsestichesky jaundice during pregnancy (in the anamnesis), cirrhosis, a high-quality hyperbilirubinemia, a liver failure, other new growths of generative organs and mammary glands, tendency to a thrombogenesis.
Overdose:
It was not studied.
Storage conditions:
Store in the dry, protected from light place. A period of validity – 5 years.
Issue conditions:
According to the recipe
Packaging:
On 1 ml of 12,5% of Solutio oleosa in ampoules No. 10.