Loratadin-OBL

General characteristics. Structure:

Active ingredient: 0,01 g of a loratadin in 1 tablet.

Excipients: lactose, potato starch, silicon dioxide colloid, polyvinylpirrolidone middlemolecular medical, magnesium stearate.

Pharmacological properties:

Pharmacodynamics. Loratadin - a blocker of H1-histamine receptors (long action). Inhibits release of a histamine and C4 leukotriene from mast cells. prevents development and facilitates the course of allergic reactions. Possesses antiallergic, antipruritic, antiexudative action. Reduces permeability of capillaries, edematization of fabrics warns, removes spasms of smooth muscles.

The antiallergic effect develops in 30 min., reaches a maximum in 8-12 h and lasts 24 h. Does not influence the central nervous system and does not cause accustoming (since does not get through a blood-brain barrier).

Pharmacokinetics. It is quickly and completely soaked up in digestive tract. Time of achievement of the maximum concentration - 1,3-2,5 h; meal slows down it on 1 h Maksmalnaya concentration at elderly people increases for 50% at alcoholic damage of a liver - with increase in disease severity. Communication with btlkmi plasmas - 97%. It is metabolized in a liver with formation of an active metabolite of a deskarboetoksiloratadin with the participation of isoenzymes of CYP3A4 P 450 cytochrome and to a lesser extent CYP2D6.

Equilibrium concentration of a loratadin and metabolite in plasma are reached for the 5th days of introduction. Does not get through a blood-brain barrier.

Elimination half-life of a loratadin - 3-20 h (on average 8,4) an active metabolite - 8,8-92 h (in chredny 28 h); At alcoholic damage of a liver the elimination half-life increases with increase in disease severity. It is removed by kidneys and through intestines. At patients with a chronic renal failure and when carrying out a hemodialysis the pharmacokinetics practically does not change.

Indications to use:

Seasonal and year-round allergic rhinitis, conjunctivitis, pollinosis, small tortoiseshell (including chronic idiopathic), Quincke's edema, allergic pruritic dermatosis; pseudo-allergic reactions, allergic reactions to stings of insects, itch of various etilogiya.

Route of administration and doses:

Inside. To adults and children with a body weight more than 30 kg - 10 mg (1 tablet) of drug once a day. A daily dose - 10 mg.

Features of use:

During treatment it is necessary to refrain from occupations potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

From a nervous system: uneasiness, excitement (at children), an adynamy, drowsiness, a hyperkinesia, paresthesias, a tremor, amnesia, a depression, increased fatigue.

From skin and a hypodermic fatty tissue: dermatitis.

From urinogenital system: urine discoloration, painful desires on an urination; dysmenorrhea, menorrhagia, vaginitis.

From a metabolism: increase in body weight, perspiration, thirst.

From a basic dvigatelnogo of the device: spasms of gastrocnemius muscles, arthralgia, mialgiya.

From the alimentary system: dryness in a mouth, taste change, anorexia, a lock or diarrhea, dyspepsia, gastritis, a meteorism, increase in appetite, stomatitis, nausea, vomiting.

From respiratory system: cough, bronchospasm, xeromycteria, sinusitis.

From the party of sense bodys: vision disorders, konjyuktivit, eye and ears pain.

From cardiovascular system: decrease or increase in arterial pressure, heartbeat.

Others: nictitating spasm, dysphonia.

Photosensitization, dorsodynia, stethalgia, fever, fever, mammary gland pain.

Interaction with other medicines:

Ethanol reduces efficiency of a loratadin.

Erythromycin, Cimetidinum, кетоконазол at combined use with loratadny increase concentration of a loratadin in a blood plasma, without causing clinical manifestations and without influencing an ECG.

Inductors of a microsomal oxidation (Phenytoinum, ethanol, barbiturates, флумецинол, rifampicin, phenylbutazone, tricyclic antidepressants) reduce efficiency of a loratadin.

Contraindications:

Hypersensitivity. Pregnancy, lactation period. Liver failure. children with body weight less than 30 kg. In communication by existence with a lactose sostaa patients with rare hereditary diseases, such as intolerance of a galactose, deficit of lactase or glyukozo-galaktozny malabsorption should not accept drug.

Overdose:

Symptoms: drowsiness, tachycardia, headache. In case of overdose it is necessary to see a doctor.

Treatment: induction of vomiting, gastric lavage, reception of absorbent carbon.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 3 years. Not to use after the date specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablet of 10 mg. On 7, 10, 15, 20 or 20 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. On 1, 2 or 3 blister strip packaging together with the application instruction in a pack from a cardboard.