Венорелакс

General characteristics. Structure:

Active ingredient: 20 mg of the dried-up mix of spirit extraction of seeds of a horse-chestnut and microcrystallic cellulose in the ratio 1:2,5 (horse-chestnut) with the content of triterpenovy saponins.

Excipients: lactose monohydrate, magnesium stearate.
 
Structure of a cover of the capsule: gelatin pharmaceutical, glycerin, sodium lauryl sulfate, the water purified titanium dioxide, quinolinic yellow E 104, a sunset yellow E 110.

The medicine reducing permeability of a capillary wall.

Pharmacological properties:

Pharmacodynamics. Medicine is applied at disturbances of venous blood circulation. Contains the dried-up spirit extraction of seeds of a horse-chestnut, has anti-exudative, venotoniziruyushchy effect. It is established that the dried-up spirit extraction of seeds of a horse-chestnut reduces concentration of lizosomalny enzymes, as a result of it disintegration of mucopolysaccharides in the field of walls of capillaries decreases.

Medicine reduces permeability of vessels, preventing filtering of low-molecular proteins, electrolytes and water in intercellular space. In randomized double blind people and cross researches decrease in transcapillary filtering and considerable reduction of hypostases, reduction feeling of weight, fatigue, tension, an itch, pain was noted.

Pharmacokinetics. Estsin who is contained in horse-chestnut seeds represents mix of triterpenovy saponins. After intake эсцин it is well absorbed from intestines. Linkng with proteins of plasma makes 84%. Is exposed to metabolism in a liver. It is brought out of an organism preferential with bile in the form of metabolites, to a lesser extent with urine (0,11% in the form of an estsin).

Indications to use:

Chronic venous insufficiency of varicose and posttrombotichesky genesis and its oslozheniye, including the diseases connected with functional disturbance of blood supply:

- hypostases, spasms in gastrocnemius muscles;

- pain and feeling of weight in legs;

- varicosity;

- hemorrhoidal nodes.

Route of administration and doses:

The adult appoint inside 1-2 capsules 3 times a day after food, a maintenance dose - 1 capsule 2-3 times a day. Duration of a course of treatment is established individually depending on efficiency and portability of therapy. Reception continues before disappearance of complaints.

Features of use:

It is not recommended to apply in the period of a lactation.

During treatment it is necessary to control function of kidneys periodically.

Side effects:

Allergic reactions at individual intolerance of components of medicine.

Interaction with other medicines:

Strengthens effect of anticoagulants.

Contraindications:

Renal failure, the I trimester of pregnancy, hypersensitivity to medicine components.

Overdose:

Strengthening of by-effects is possible.

Treatment: medicine cancellation; if necessary carry out symptomatic therapy.

Storage conditions:

In the place protected from moisture and light at a temperature from 15 °C to 25 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

On 30 or 50 capsules in banks in packaging No. 1.