Glutargin concentrate of 40% 5 ml of N10

General characteristics. Structure:

International name: Arginine glutamate;
main physical and chemical properties: transparent liquid of yellowish color; 
structure: 1 ml of solution supports arginine of a glutamate (in terms of 100% substance) 400 mg; 
excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. Glutargin is compound of arginine and glutaminic acid which play an important role in ensuring biochemical processes of neutralization and removal from an organism of a highly toxic metabolite of exchange of nitrogenous substances – ammonia. Gipoammoniyemichesky effects of drug are implemented by activation of neutralization of ammonia in an ornitinovy cycle of synthesis of urea, binding of ammonia in a non-toxic glutamine, and also strengthenings of removal of ammonia from the central nervous system and its excretion from an organism. Thanks to these properties of Glutargin effects of ammonia decrease all-toxic, including neurotoxic. 
Glutargin has also hepatoprotective effect, having antioxidant, anti-hypoxemic and membrane stabilizing properties, positively influences processes of power supply in hepatocytes. 
At a drunkenness Glutargin stimulates utilization of alcohol in monooksigenazny system of a liver, prevents oppression of key enzyme of utilization of ethanol – alcohol dehydrogenase; accelerates an inactivation and removal of toxic products of metabolism of ethanol as a result of increase in education and oxidation of succinic acid; reduces oppressing influences of alcohol on TsNS due to neuromediator properties of exciting glutaminic acid. Thanks to these properties Glutargin shows the anti-toxic and sobering effects.
Glutargin does not render embriotoksichesky, gonadotoksichesky and mutagen effects, does not cause allergic and immunotoxic reactions.

Indications to use:

Acute and chronic hepatitises of various etiology, poisoning with hepatotropic poisons (death angel, chemical and medicinal substances), cirrhosis, leptospirosis. Hepatic encephalopathy, a prekoma and a coma which are followed by a giperammoniyemiya. Condition of acute alcoholic poisoning of average and heavy degree, including alcoholic encephalopathy and coma. The Postintoksikatsionny frustration caused by alcohol intake.

Route of administration and doses:

Drug is appointed the adult intravenously. Enter kapelno on 2 times a day on 5 ml (2 g) on 150–250 ml of isotonic solution of sodium of chloride, with a speed of 60-70 thaws a minute. In hard cases the daily dose of drug raises to 15–20 ml (6–8 g). A course of treatment – 5–10 days. The highest daily dose – 20 ml (8 g). 
For treatment of alcoholic poisoning appoint 2 ml (0,8 g) 2 times a day within 2–3 days, then the dose is reduced to 1 ml (0,4 g) by 2 times a day within 10 days. In hard cases (an alcoholic coma) the daily dose raises to 5 ml (2 g) 2 times a day. 
After a course of treatment of 40%, if necessary, it is necessary to pass with Glutargin's solution to use of tablets of Glutargin.

Features of use:

At appointment patients with disturbances of functions of closed glands should consider that drug stimulates secretion of insulin and a growth hormone.

Side effects:

It is not established.

Interaction with other medicines:

At simultaneous use Aminophyllinum exponentiates increase in concentration of endogenous insulin in blood.

Contraindications:

Relative contraindication are feverish states, a hyperexcitability and violently proceeding psychotic reactions, heavy disturbances of filtrational (azotovydelitelny) function of kidneys.

Overdose:

Symptoms: pain in a thorax, an atrioventricular block. 
Treatment: in these cases intravenous administration of corticosteroids is necessary.

Storage conditions:

To store in the place protected from light. To store in the place, unavailable to children.
Period of validity – 2 years.

Issue conditions:

According to the recipe

Packaging:

On 5 ml in an ampoule. On 10 ampoules in a cardboard pack.