Glutargin, the tab. on 0,75 g No. 10х3

General characteristics. Structure:

Active ingredient: arginine glutamate; 1 tablet supports arginine of a glutamate of 0,25 g or arginine of a glutamate (in terms of 100% substance) 0,75 g or 1 g; excipients: tablet of 0,25 g: potato starch, calcium stearate, cellulose microcrystallic; tablet of 0,75 g and 1 g: cellulose microcrystallic (MKTs 101), кросповидон, calcium stearate.

Pharmacological properties:

Glutargin – salt of arginine and glutaminic acid which play an important role in ensuring biochemical processes of neutralization and removal from an organism of a highly toxic metabolite of exchange of nitrogenous substances – ammonia. Gipoammoniyemichesky effects of drug are implemented by activation of neutralization of ammonia in an ornitinovy cycle of synthesis of urea, binding of ammonia in a non-toxic glutamine, and also strengthenings of removal of ammonia from the central nervous system and its excretion from an organism. Thanks to these properties of Glutargin effects of ammonia decrease all-toxic, including neurotoxic.
Glutargin has also hepatoprotective effect caused by antioxidant, anti-hypoxemic and membrane stabilizing properties, positively influences processes of power supply in hepatocytes.
At a drunkenness Glutargin stimulates utilization of alcohol in monooksigenazny system of a liver, prevents oppression of key enzyme of utilization of ethanol – alcohol dehydrogenase; accelerates an inactivation and removal of toxic products of metabolism of ethanol as a result of increase in education and oxidation of succinic acid; reduces the oppressing influence of alcohol on TsNS due to neuromediator properties of exciting glutaminic acid. Thanks to these properties Glutargin shows anti-toxic and sobering effects.
Glutargin does not render embriotoksichesky, gonadotoksichesky, mutagen and teratogenic effects, does not cause allergic and immunotoxic reactions.

Indications to use:

As a part of complex therapy of acute and chronic hepatitises of various etiology, including at poisoning with hepatotropic poisons (a death angel, chemical and medicinal substances), at cirrhosis, leptospirosis. The hepatic encephalopathy which is followed by a giperammoniyemiya.
Condition of acute alcoholic poisoning easy and moderately severe, the hungover syndrome, postintoksikatsionny frustration caused by alcohol intake.

Route of administration and doses:

Drug is appointed the adult inside. Hepatitises, giperammoniyemiya. Appoint 3 tablets on 0,25 g (0,75 g) or 1 tablet on 0,75 g 3 times a day within 15 days, irrespective of meal. If necessary the dose of drug and a course of treatment can be increased up to 20 days. The highest single dose makes 2 g, the highest daily – 8 g.

Alcoholic poisoning. Appoint 4 tablets on 0,25 g (1 g) or 1 tablet on 1 g 4 times in bucketed day of 1-2,5 h, in the next 2-3 days – 2 tablets on 0,25 g (0,5 g) or? tablets on 1 g 3 times a day. At alcoholic poisoning of heavy degree after a course of treatment injection drugs of Glutargin appoint Glutargin's tablets: 3 tablets on 0,25 g (0,75 g) or 1 tablet on 0,75 g 2 times a day, or 1? tablets on 1 g of 1 times a day within 20 days. For prevention of a drunkenness - 2 g in 60 - 120 min. prior to alcohol intake.

Features of use:

Use during pregnancy or feeding by a breast. Safety of a clinical use of drug during pregnancy and feeding by a breast is not investigated.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Does not influence.

Children. Efficiency and safety of use of drug at children's and teenage age are not investigated.

Side effects:

The feeling of slight discomfort in digestive tract and nausea directly after drug use which pass independently can seldom be observed.

Interaction with other medicines:

Glutargin's effect on secretion of insulin increases at simultaneous use of Aminophyllinum. Glutargin can strengthen effect of anti-aggregation means (Dipiridamolum, etc.). Warns and weakens the neurotoxic phenomena which can arise at use of an isoniazid. Weakens effect of vinblastine.

Contraindications:

Relative contraindication are fever, a hyperexcitability, heavy disturbances of filtrational (azotovydelitelny) function of kidneys.

Overdose:

Symptoms: thorax pain, an atrioventricular block, inherent for glutaminic acid, are possible. Treatment: intravenous administration of corticosteroids.

Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.

Period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

Tablets on 0,25 g No. 10х3, No. 10х6 in blister strip packagings in a pack;
tablets on 0,75 g No. 10х3, No. 10х5 in blister strip packagings in a pack;
tablets on 1 g No. 1х2, No. 10х1 in blister strip packagings in a pack.