Glutargin, the tab. on 0,25g No. 10х3

General characteristics. Structure:

International and chemical names: Arginine glutamate;
main physical and chemical properties: tablets of white color, with a flat surface, risky and a facet; 
structure: 1 tablet supports arginine of a glutamate of 0,25 g; 
excipients: potato starch, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Glutargin is compound of arginine and glutaminic acid which play an important role in ensuring biochemical processes of neutralization and removal from an organism of a highly toxic metabolite of exchange of nitrogenous substances – ammonia. Gipoammoniyemichesky effects of drug are implemented by activation of neutralization of ammonia in an ornitinovy cycle of synthesis of urea, binding of ammonia in a non-toxic glutamine, and also strengthenings of removal of ammonia from the central nervous system and its excretion from an organism. Thanks to these properties of Glutargin effects of ammonia decrease all-toxic, including neurotoxic. 
Glutargin has also hepatoprotective effect, having antioxidant, anti-hypoxemic and membrane stabilizing activity, positively influences processes of power supply in hepatocytes. 
At a drunkenness Glutargin stimulates utilization of alcohol in monooksigenazny system of a liver, prevents oppression of key enzyme of utilization of ethanol – alcohol dehydrogenase; accelerates an inactivation and removal of toxic products of metabolism of ethanol as a result of increase in education and oxidation of succinic acid; reduces the oppressing influence of alcohol on TsNS due to neuromediator properties of exciting glutaminic acid. Thanks to these properties Glutargin shows the anti-toxic and sobering effects.
Glutargin does not render embriotoksichesky, gonadotoksichesky and mutagen effects, does not cause allergic and immunotoxic reactions.

Indications to use:

Acute and chronic hepatitises of various etiology, poisoning with hepatotropic poisons (death angel, chemical and medicinal substances), cirrhosis, leptospirosis. The hepatic encephalopathy, a prekoma and a coma which are followed by a giperammoniyemiya. A condition of acute alcoholic poisoning easy and moderately severe, the hungover syndrome, postintoksikatsionny frustration caused by alcohol intake.

Route of administration and doses:

Drug is appointed by the adult on 3 tablets (0,75 g) by 3 times a day within 15 days, irrespective of meal. If necessary the dose of drug and a course of treatment can be increased up to 20 days. The highest single dose makes 2 g, the highest daily – 8 g.
For treatment of alcoholic poisoning appoint 4 tablets (1,0 g) 4 times in bucketed day of 1-2,5 h, in the next 2–3 days – on 2 tablets (0,5 g) 3 times a day. At alcoholic poisoning of heavy degree, after a course of treatment injection drugs of Glutargin, appoint Glutargin's tablets – on 3 tablets (0,75 g) 2 times a day within 20 days. For prevention of a drunkenness – 2 g in 60–120 min. prior to reception алкогол

Features of use:

At appointment patients with disturbances of functions of closed glands should consider that drug stimulates secretion of insulin and a growth hormone. 
Experience of use for children, pregnant women and during feeding by a breast insufficient. 

Side effects:

The feeling of slight discomfort in digestive tract and nausea directly after drug use which takes place independently can seldom be observed.

Interaction with other medicines:

At simultaneous use Aminophyllinum exponentiates increase in concentration of endogenous insulin in blood.

Contraindications:

Relative contraindication are the feverish state, a hyperexcitability and psychotic reactions with a rapid current, heavy disturbances of filtrational (azotovydelitelny) function of kidneys.

Overdose:

Symptoms: pain in a thorax, an atrioventricular block. In these cases intravenous administration of corticosteroids is necessary.

Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.
Period of validity – 2 years.

Issue conditions:

Without recipe

Packaging:

Tablets on 0,25 g No. 10х3 or No. 10х6 in blister strip packagings.