Метоклопрамид-Акри®

General characteristics. Structure:

Active ingredient: 0,01 g of Metoclopramidum of a hydrochloride in 1 tablet.

Excipients: lactose, potato starch, silicon dioxide colloid, magnesium stearate.

Pharmacological properties:

Pharmacodynamics. The specific blocker of dopamine (D2) and serotoninovy (5-HT3) receptors, oppresses chemoceptors of a trigger zone of a brainstem, weakens sensitivity of the visceral nerves transferring impulses from a pylorus and a duodenum to the emetic center. Through a hypothalamus and a parasympathetic nervous system (a digestive tract innervation) exerts the regulating and coordinating impact on a tone and a physical activity of an upper part of digestive tract (including a tone of the lower sphincter of a gullet).

Raises a tone of a stomach and intestines, accelerates gastric emptying, reduces hyperacid стаз, interferes with a peloric and ezofagealny reflux, stimulates an intestines peristaltics. Normalizes department of bile, reduces a spasm of a sphincter of Oddi. Without changing its tone, eliminates dyskinesia of a gall bladder. Kidneys and a liver, on blood formation, secretion of a stomach and pancreas do not influence a tone of blood vessels of a brain, arterial pressure, breath function, and also. Stimulates prolactin secretion. Increases sensitivity of fabrics to acetylcholine (action does not depend on a vagal innervation, but is eliminated with holinoblokator). Stimulating secretion of Aldosteronum, strengthens Na delay + and removal of K+.

Pharmacokinetics. It is quickly soaked up from digestive tract. Due to the partial destruction in a liver after absorption bioavailability — 75%. The maximum concentration in blood are proportional to the accepted dose, and are reached in 1-2 hours. Communication with proteins of plasma — 13-30%. The elimination half-life makes from 2,5 to 6 hours, at a renal failure — till 14 o'clock.

Removal of drug happens generally through kidneys within 24 hours in an invariable look and in the form of conjugates. Passes through placental and hematoencephalic barriers and gets into maternal milk.

Indications to use:

Vomiting, nausea, hiccups of various genesis (it can be in certain cases effective at the vomiting caused by reception of tsitostatik). Atony and hypotonia of a stomach and intestines (in particular, postoperative); dyskinesia of biliary tract; reflux esophagitis; meteorism; as a part of complex therapy of aggravations of a peptic ulcer of a stomach and a duodenum. Need of strengthening of a vermicular movement when carrying out X-ray contrast researches of digestive tract.

Route of administration and doses:

Inside, in 30 minutes prior to food, washing down with a small amount of water. Adults — on 5-10 mg 3-4 times a day.

The maximum single dose — 20 mg, daily — 60 mg. Children are more senior than 6 years — on 5 mg 1-3 times a day.

Features of use:

To children from 2 to 6 years Metoclopramidum is appointed in drops or parenterally.

It is not effective at vomiting of vestibular genesis.

Against the background of use of Metoclopramidum distortions of these laboratory indicators of function of a liver and definition of concentration of Aldosteronum and prolactin in plasma are possible.

At administration of drug it is necessary to avoid potentially dangerous types of activity demanding the increased concentration of attention, bystry mental and motor reaction (driving of vehicles, etc.).

The majority of side effects arises within 36 hours from an initiation of treatment and passes within 24 hours after cancellation. Treatment has to be whenever possible short-term.

During treatment by drug alcohol intake is not recommended.

Side effects:

From a nervous system: extrapyramidal frustration — a spasm of facial muscles, a lockjaw, a rhythmic protrusion of language, bulbar type of the speech, a spasm of extraocular muscles (including okulogirny crisis), a spastic wryneck, an opisthotonos, a muscle hyper tone; parkinsonism (a hyperkinesia, muscular rigidity - manifestation dopamine - the blocking action, the risk of development in children and teenagers increases at exceeding of a dose of 0,5 mg/kg/days); dyskineses (at elderly, at HPN); drowsiness, fatigue, uneasiness, confusion, headache, sonitus.

From the alimentary system: a lock or diarrhea, it is rare — dryness in a mouth.

Allergic reactions: small tortoiseshell.

From endocrine system: seldom (at long reception in high doses) — a gynecomastia, a galactorrhoea, disturbance of a menstrual cycle.

Others: in an initiation of treatment the agranulocytosis is possible, it is rare (at use in high doses) — a hyperemia of a mucous membrane of a nose.

Interaction with other medicines:

Strengthens effect of ethanol on TsNS, sedation of hypnagogues, increases efficiency of therapy of N2-gistaminoblokator.

Increases absorption of tetracycline, ampicillin, paracetamol, acetylsalicylic acid, a levodopa, ethanol; slows down absorption of digoxin and Cimetidinum.

At simultaneous use with neuroleptics the risk of development of extrapyramidal symptoms increases.

Antikholinesterazny means can weaken action of Metoclopramidum.

Contraindications:

Hypersensitivity to components of drug, bleeding from digestive tract, a pyloric stenosis, mechanical intestinal impassability, perforation of a stomach or intestines, a pheochromocytoma, epilepsy, glaucoma, extrapyramidal disturbances, Parkinson's disease, prolaktinozavisimy tumors, vomiting against the background of treatment or overdose by neuroleptics and at patients with cancer of a mammary gland, pregnancy (1 trimester), the lactation period, early children's age (up to 2 years). Do not appoint after GIT operations (such as pyloroplasty or anastomosis of intestines) as vigorous muscular contractions interfere with healing.

With care — children's age, a renal/liver failure, bronchial asthma, arterial hypertension.

Overdose:

The hypersomnia, disorientation and extrapyramidal frustration can be noted. As a rule, the symptomatology disappears after the termination of administration of drug within 24 hours. If necessary treatment is carried out by holinoblokator and protivoparkinsonichesky means.

Storage conditions:

List B. In dry, protected from light, the place, unavailable to children, at a temperature not above 25 °C. Not to apply after the period of validity specified on packaging. A period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

Tablets on 0,01 g. On 10 tablets in blister strip packagings. 2, 4 or 5 blister strip packagings together with the application instruction place in a pack from a cardboard.