Primobol

General characteristics. Structure:

Active ingredient: 50 mg of a methenobosom of acetate (in recalculation on methenobosoms) in 1 tablet.

Excipients: magnesium stearate, лудипрессо (lactose, povidone, кросповидон).

Pharmacological properties:

Pharmacodynamics. Methenobosoms is steroid anabolic steroid. Getting in a cellular kernel, activates the genetic device of a cell that leads to increase in synthesis of DNA, RNA and structural proteins, activation of enzymes of a chain of tissue respiration and strengthening of tissue respiration, oxidizing phosphorylation, synthesis of ATP and accumulation of makroerg in a cell. Stimulates anabolic and suppresses the catabolic processes caused by glucocorticoids.

Leads to increase in muscle bulk, reduction of adiposities, improves a trophicity of fabrics, promotes adjournment of calcium in bones, detains in an organism sodium and water. Hemopoietic action is connected with increase in synthesis of erythropoetin. Androgenic activity (low) can promote development of secondary sexual characteristics in men's type.

Indications to use:

Protein synthesis disturbances, cachexia of a different origin; injuries, extensive burns, after infectious diseases and radiation; muscular dystrophy, osteoporosis, negative nitrogenous balance at corticosteroid therapy, hypo - and aplastic anemia.

Route of administration and doses:

The adult it is appointed in a dose of 2-3 mg/kg. Duration of treatment makes 3 months and can be prolonged depending on result.

Features of use:

At emergence of the first signs of virilescence in women (voice coarsening, a hirsutism, eels, a clitoromegaly), reception should be stopped not to allow irreversibility of changes. To periodically check the level of a lipidemiya and cholesterinemia.

Side effects:

Women have symptoms of virilescence, frustration of a menstrual cycle.

At men: in the prepubertatny period – virilescence symptoms, delay or the termination of growth (calcification of epiphyseal growth zones of tubular bones); in the post-pubertal period – a gynecomastia, a priapism, oppression of a spermatogenesis.

Men and women have a progressing of atherosclerosis, peripheral hypostases, disturbance of functions of a liver, change in a leukocytic formula, long tubular bone pain.

Interaction with other medicines:

Strengthens effect of anticoagulants, antiagregant and hypoglycemic means, and also side effects of gepatotoksichny drugs.

Contraindications:

Hypersensitivity to drug, a prostate cancer, a breast cancer at men, a carcinoma of a mammary gland at women with a hypercalcemia, an ischemic heart disease, the expressed atherosclerosis, a liver and renal failure, acute and chronic prostatitis, pregnancy, feeding by a breast.

Overdose:

Cases of overdose are not registered.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets of 10 mg and 50 mg. On 10 or 20 tablets in the blister. On 5, 15, 25, 50, 100, 500 tablets in packages. On 5, 15, 25, 50, 100 tablets in bottles.