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medicalmeds.eu Medicines Antispasmodic. Drotaverinum

Drotaverinum

Препарат Дротаверин. ОАО "Органика" Россия


Producer: JSC Organika Russia

Code of automatic telephone exchange: A03AD02

Release form: Firm dosage forms. Tablets.

Indications to use: Pain syndrome. Digestive tract spasms. Spastic lock. Chronic spastic colitis. Tenesmus. Intestinal colic. Renal colic. Algodismenorey.


General characteristics. Structure:

Active ingredient: 40 mg of Drotaverinum.

Excipients: lactoses monohydrate, povidone (коллидон 25), кросповидон (коллидон CL), magnesium stearate, potato starch, talc.

The medicine having the spasmolytic and anesthetizing activity concerning smooth muscles. 




Pharmacological properties:

Pharmacodynamics. Spasmolysant of myotropic action. On chemical structure and pharmacological properties it is close to a papaverine, however surpasses it in efficiency and duration of action. Reduces a tone of unstriated muscles of internals, reduces their physical activity. Has vazodilatiruyushchy effect.

Pharmacokinetics. After intake Drotaverinum is quickly absorbed from a GIT. Bioavailability - about 100%. Does not get through GEB.


Indications to use:

Prevention and treatment of the functional disturbances and pain syndrome caused by a spasm of smooth muscles (including the spasms of a GIT, urinary tract connected with a cholelithiasis, cholecystitis, a peptic ulcer of a stomach, duodenum; spasm of peloric and cardial department of a stomach; spastic locks, spastic colitis; proctitis, tenesmus; postoperative gripes owing to a delay of gases; in connection with a nephrolithiasis, a pyelitis); when carrying out tool researches; spasms of peripheral arteries, brain vessels; альгодисменорея.

For decrease in excitability of a uterus at pregnancy; at a uterus pharynx spasm in labor, long disclosure of a pharynx, puerperal pains, the menacing abortion.


Route of administration and doses:

Inside, in oil, in/in or п / to adults - on 40-80 mg of 1-3 times/days. At hepatic and renal gripes it is recommended to enter in/in slowly in a dose of 40-80 mg.

At spasms of peripheral arteries Drotaverinum can be entered in / and.

For children under 6 years at intake the single dose makes 10-20 mg, 6-12 years - 20 mg, the frequency of use of 1-2 times/days.


Features of use:

With care apply at patients with the expressed atherosclerosis of coronary arteries.

Drotaverinum can be used as a part of a combination therapy for stopping of hypertensive crisis.

With care apply at pregnancy and in the period of a lactation (breastfeeding).

Use for children. For children under 6 years at intake the single dose makes 10-20 mg, 6-12 years - 20 mg, the frequency of use of 1-2 times/days.


Side effects:

From cardiovascular system: heartbeat, feeling of heat; at in introduction cases of decrease in the ABP (are noted up to a collapse), development of AV blockade, emergence of arrhythmias.

From respiratory system: at in introduction cases of oppression of a respiratory center are noted.

Others: dizziness, sweating strengthening.


Interaction with other medicines:

At simultaneous use with tricyclic antidepressants, quinidine, procaineamide the decrease in the ABP caused by tricyclic antidepressants, quinidine and procaineamide amplifies.

At simultaneous use spazmogenny activity of morphine decreases.

At simultaneous use with a levodopa reduction of antiparkinsonichesky effect of a levodopa is possible.

At simultaneous use action of a papaverine, Bendazolum and other spasmolysants amplifies (including m-holinoblokatorov).

At simultaneous use with phenobarbital expressiveness of spasmolytic action of Drotaverinum increases.


Contraindications:

Period of a lactation (breastfeeding). Hypersensitivity to Drotaverinum.


Overdose:

In high doses breaks atrioventricular conductivity, reduces excitability of a cardiac muscle, can cause a cardiac standstill and paralysis of a respiratory center.


Storage conditions:

To store in dry, protected from light and the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

10 tablets in planimetric strip packagings and in packs cardboard.



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