Paraskofen

General characteristics. Structure:

Active ingredients: 200 mg of acetylsalicylic acid, 200 mg of paracetamol, 40 mg of caffeine.

Pharmacological properties:

Pharmacodynamics. Effect of drug is defined by the components which are a part of drug. Has anesthetic, febrifugal and antiinflammatory effect.

Acetylsalicylic acid has the antiinflammatory, febrifugal and analgetic effect caused by disturbance of synthesis of prostaglandins.

Paracetamol possesses the analgetic and poorly expressed antiinflammatory action. It is connected with preferential influence on the center of thermal control in a hypothalamus.

Caffeine causes expansion of blood vessels of skeletal muscles, a brain, heart, kidneys; increases intellectual and physical effeciency; increases arterial pressure at hypotension; promotes elimination of exhaustion and drowsiness; increases permeability of gistogematichesky barriers and increases bioavailability of non-narcotic analgesics, promoting thereby strengthening of therapeutic effect of acetylsalicylic acid and paracetamol.

Pharmacokinetics. Acetylsalicylic acid: after intake it is quickly soaked up preferential in proximal department of a small bowel and to a lesser extent in a stomach. During adsorption is exposed to presistemny elimination in a wall of intestines and in a liver it (is deacetylated). Rezorbirovannya a part is very quickly hydrolyzed by esterases (T1/2 makes no more than 15-20 minutes). In an organism anion of salicylic acid circulates. Acetylsalicylic acid is distributed in the majority of fabrics and fluid mediums of an organism. Diffusion accelerates in the presence of a hyperemia and hypostasis, is slowed down in a proliferative zone of an inflammation. Gets through GEB and a placenta, in small amounts it is allocated with breast milk. Presence of food at a stomach considerably changes absorption of acetylsalicylic acid. It is metabolized in a liver by hydrolysis with formation of salicylic acid with the subsequent conjugation with glycine or a glucuronide. About 80% of salicylic acid contact proteins of a blood plasma. T1/2 of acetylsalicylic acid makes about 15 min., salicylic acid - about 3 h. It is removed by kidneys preferential in the form of salicylic acid. Caffeine is well soaked up in intestines, an elimination half-life – 5 h (sometimes 10 h). About 10% in an invariable look are removed preferential by kidneys in a look. Paracetamol is quickly soaked up their digestive tract, generally in a small bowel, by passive transport. It is distributed in fabrics and generally in fluid mediums of an organism, except for fatty tissue and cerebrospinal fluid. T1/2 of paracetamol makes 1-4 hours. At patients with cirrhosis of T1/2 It is slightly more metabolized in a liver with formation of a glyukoronid and sulfate of paracetamol, with the participation of the mixed oxidases of a liver and P450 cytochrome. Linkng with proteins makes less than 10% and slightly increases at overdose. Sulphatic and glyukuronidny metabolites do not contact proteins of plasma. It is removed by kidneys in the form of products of conjugation, less than 5% are excreted in an invariable look.

Indications to use:

Moderately or poorly expressed pain syndrome of various genesis (including a headache, a dentagra, joint pains, migraine, neuralgia, a mialgiya, a sciatica, a dysmenorrhea, etc.). For decrease in the increased body temperature at catarrhal and other infectious and inflammatory diseases.

Route of administration and doses:

Appoint inside after food 1-2 tablets 2-3 times a day. The maximum single dose for adults - 2 tablets, daily - 6 tablets. The break between receptions has to make not less than 6 hours. At renal failures or a liver the break between administrations of drug has to be no more than 8 hours.

It is not necessary to accept drug more than 5 days as anesthetic and more than 3 days as febrifugal without appointment and observation of the doctor. Other dosages and schemes of use are established by the doctor.

Features of use:

The risk of toxic action increases at patients with alcoholic diseases of a liver of not cirrhotic character.

Side effects:

Skin allergic reactions (rash, an itch a small tortoiseshell), heartbeat dizziness, nausea, pains in a stomach are in rare instances possible. At long reception in high doses can arise a renal failure or a liver.

Interaction with other medicines:

Strengthens action of the means reducing fibrillation and aggregation of thrombocytes, and also side effects of the glucocorticoids derivative of a sulfonilmochesvina, a methotrexate, non-narcotic analgesics, and nonsteroid protivospalitelny means. It is necessary to avoid a drug combination with barbiturates, anticonvulsants, rifampicin, alcohol.

Use of other medicines together with Paraskofen has to be coordinated with the doctor.

Contraindications:

Hypersensitivity to drug components. Peptic ulcer of a stomach and duodenum; gastrointestinal bleedings (including in the anamnesis); the expressed abnormal liver functions and/or kidneys. Genetic absence 6-fosfatdegidrogenaza glucose.

Blood diseases with tendency to hemorrhages and bleedings. Glaucoma, bronchial asthma. The I trimester of pregnancy, a lactation, children up to 15 years. Drug should not be used at children and teenagers with the acute and respiratory diseases caused by a viral infection (danger of development of a syndrome of Ray).

Overdose:

Symptoms: nausea, vomiting, pains in a stomach, perspiration, pallor of integuments, tachycardia. At suspicion of poisoning it is necessary to ask for medical assistance.

Treatment: induction of vomiting, a chrezzondovy gastric lavage within the first 4 hours after administration of drug in high doses, purpose of absorbent carbon, the symptomatic therapy directed to maintenance of the vital functions.

Issue conditions:

Without recipe

Packaging:

Tablets in planimetric bezyacheykovy packaging or a blister strip packaging No. 10.