Askofen-P

General characteristics. Structure:

Active agents; acetylsalicylic acid - 200 mg paracetamol – 200 mg caffeine – 40 mg.

Excipients - starch, kislotalimonny, polyvinylpirrolidone (povidone), talc, calcium stearate.

Pharmacological properties:

Pharmacokinetics. Acetylsalicylic acid is quickly and completely absorbed generally in upper parts of a small bowel. The period of semi-absorption makes 5-16 min. Milk and antacids do not reduce absorption speed. Acetylsalicylic acid and its main metabolite (salicylic acid) contact proteins through the phenolic hydroxylic groups. It is removed preferential through kidneys.

Paracetamol is quickly and almost completely soaked up from digestive tract, evenly distributed in fabrics. The maximum concentration in a blood plasma is reached in 2,5 h, an elimination half-life – 2-4 h, bioavailability about 90%, extent of linkng with blood proteins – 25-50%, metabolized generally in a liver (to 80-90%). The combination of acetylsalicylic acid and paracetamol provides more expressed and long analgeziruyushchy, antipyretic and antiinflammatory effect, than at their separate reception in equivalent doses that is caused by possible competition between acetylsalicylic acid and paracetamol for linkng with proteins of a blood plasma, and paracetamol shows big reactogenicity. These are extends the circulation period in blood of free (active) acetylsalicylic acid a little. Caffeine exponentiates effect of paracetamol and acetylsalicylic acid.

Pharmacodynamics. Askofen P - the combined drug which effect is caused by effects of the components which are its part.

Acetylsalicylic acid possesses febrifugal and antiinflammatory action, weakens the pain which is especially caused by inflammatory process and also moderately oppresses aggregation of thrombocytes and a thrombogenesis, improves microcirculation in the inflammation center.

Paracetamol possesses analgetic, febrifugal and weak antiinflammatory action that is connected with its influence on the center of thermal control in a hypothalamus and less expressed ability to inhibit synthesis of prostaglandins in peripheral fabrics.

Caffeine increases reflex irritability of a spinal cord, excites the respiratory and vasomotor centers, expands blood vessels of skeletal muscles, a brain, heart, kidneys, reduces aggregation of thrombocytes; reduces drowsiness, feeling of fatigue, increases intellectual and physical effeciency. In this combination caffeine in a small dose has practically no promoting effect on TsNS, however contributes to normalization of a tone of vessels of a brain and acceleration of a blood-groove.

Indications to use:

- moderately expressed pain syndrome of various etiology: headache, migraine, dentagra, neuralgia, arthralgia, mialgiya, альгодисменорея);

- feverish states at catarrhal and rheumatic diseases.

Route of administration and doses:

Accept inside on 1 tablet 2-3 times a day after food. The highest daily dose makes 6 tablets in 3 receptions. The course of treatment depends on efficiency of therapy and, as a rule, does not exceed 10 days.

Course of treatment - no more than 5-7 days as anesthetic and no more than 3 days – as an antipyretic.

Features of use:

At long use of drug control of peripheral blood and a functional condition of a liver is necessary. As acetylsalicylic acid has antiagregantny effect, the patient if surgical intervention is necessary to it, has to warn the doctor about administration of drug in advance. Acetylsalicylic acid in low doses reduces removal of uric acid. It can provoke a gout attack in some cases.

During treatment it is necessary to refuse the use alcohol of the containing drinks (increase in risk of gastrointestinal bleeding).

Does not influence ability to manage the vehicle or potentially dangerous mechanisms.

Side effects:

- anorexia, nausea, vomiting, gastralgia, diarrhea;

- digestive tract erosive cankers;

- gastrointestinal bleedings;

- liver and/or renal failure;

- increase in arterial pressure;

- tachycardia;

- allergic reactions (skin rash, Quincke's edema, bronchospasm).

At long reception:

- dizziness, headache;

- vision disorders, sonitus;

- decrease in aggregation of thrombocytes, hypocoagulation;

- hemorrhagic syndrome (nasal bleeding, bleeding of gums, purple, etc.);

- damage of kidneys with a papillary necrosis;

- deafness;

- Stephens-Johnson's syndrome;

- toxic epidermal necrolysis (Lyell's disease);

- a syndrome Reja at children (a metabolic acidosis, disturbances from a nervous system and mentality, vomiting, abnormal liver functions).

Interaction with other medicines:

Strengthens effect of heparin, indirect anticoagulants, Reserpinum, steroid hormones and hypoglycemic means. Reduces efficiency of Spironolactonum, furosemide, hypotensive drugs, the antigouty means promoting removal of uric acid.

Strengthens side effects of glucocorticosteroids, derivative sulphonylurea, a methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

It is necessary to avoid a drug combination with barbiturates, antiepileptic means, a zidovudine, rifampicin and alkogolsoderzhashchy drinks (increases risk of hepatotoxic effect). Under the influence of paracetamol time of removal of chloramphenicol increases by 5 times. Caffeine accelerates ergotamine absorption.

Salicylamidum, etc. stimulators of a microsomal oxidation promote formation of the toxic metabolites of paracetamol influencing function of a liver. Metoclopramidum accelerates paracetamol absorption. At repeated reception paracetamol can strengthen effect of anticoagulants (Dicumarinum derivatives).

Contraindications:

- hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NPVP) or xanthines; hypersensitivity to other components of drug;

- digestive tract erosive cankers (in an aggravation phase), gastrointestinal bleeding;

- the expressed abnormal liver functions or kidneys;

- asthma induced by reception of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;

- hemorrhagic diathesis (angiohemophilia, hemophilias, telangiectasias, gipotrombinemiya, thrombocytopenia, Werlhof's disease);

- the stratified aortic aneurysm;

- deficit glyukozo-6-fosfatdegidrogenazy;

- portal hypertensia, deficit of vitamin K;

- hyperexcitability, sleep disorder, alarming frustration (agoraphobia, panic frustration);

- organic diseases of cardiovascular system (acute myocardial infarction, heavy course of coronary heart disease, arterial hypertension), Bouveret's disease, frequent ventricular premature ventricular contraction;

- glaucoma;

- the surgical interventions which are followed by bleeding;

- children's age up to 15 years;

- pregnancy and period of a lactation.

Overdose:

Symptoms: pains in a stomach, nausea, vomiting, gastrointestinal bleedings, disturbances of functions of a liver and kidneys, anaphylactic reactions.

At considerable overdose - confusion of consciousness, an asthma, suffocation attacks, dehydration, a coma.

Treatment: gastric lavage, salt laxative, absorbent carbon, infuzny administration of solution of Natrii hydrocarbonas, sodium of citrate, sodium of a lactate, Acetylcysteinum sodium.

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 30 °C.

To store in places, unavailable to children!

Issue conditions:

Without recipe

Packaging:

On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil.

Planimetric packagings place in boxes from a cardboard of bandbox or corrugated fibreboard. Put instructions on a medical use in boxes in the state and Russian languages by the number of packagings.