Фунготербин® tablets

General characteristics. Structure:

Contains in one tablet: a terbinafina – 0,25 g and excipients (cellulose microcrystallic, коллидон CL-M, коллидон 30, aerosil, the benzoic acid, magnesium stearate).

Pharmacological properties:

Terbinafin – Fungoterbin®-a active agent, represents allylamine and possesses a wide range of antifungal action. It is active concerning such dermatophytes as Trychophyton (T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans), Microsporum canis, Epidermophyton floccosum. In low concentration has fungicidal effect concerning dermatophytes, mold mushrooms (Aspergillus, Cladosporium, Scopulariopsis brevicaulis and others) and some dimorphous mushrooms. Action on barmy mushrooms of the sort Candida and its mitselialny forms can be fungicidal or fungistatic, depending on a species of a mushroom. Terbinafin is active also concerning Pityrosporum – the activator multi-colored (scaly) depriving of Pytyriasis versicolor caused by Pityrosporum ovale. Terbinafin breaks the biosynthesis of ergosterol happening in mushrooms at early stages by inhibition of the enzyme of a skvalenepoksidaza located on a cellular membrane of a mushroom. It leads to deficit of ergosterol and to intracellular accumulation of squalene that causes death of a cell of a mushroom.

Indications to use:

- Onychomycoses

- Mycoses of a pilar part of the head (trichophytosis, microsporia)

- Fungus diseases of smooth skin

– treatment of widespread dermatomycoses of a trunk and extremities

- Candidiases of skin and mucous, the sorts Candida caused by mushrooms

– when localization and prevalence of process cause expediency of peroral therapy.

Route of administration and doses:

Inside. Duration of a course of treatment and the mode of dosing is set individually and depends on localization of process and disease severity. The adult usually appoint inside after food on 1 tablet (250 mg) once a day. To patients with a liver and renal failure - 1/2 tablets (125 mg) once a day. Mycoses of integuments the Recommended treatment duration: A dermatomycosis of feet (mezhpalytsevy, bottom or as "socks"): 2-6 weeks the Dermatomycosis of a trunk, extremities — 2-4 weeks Candidiasis of skin and mucous - 2-4 weeks. Total disappearance of clinical displays of a disease is observed, as a rule, in several weeks after mycologic treatment. Mycoses of a pilar part of the head the Recommended treatment duration: Mycosis of a pilar part of the head - about 4 weeks. Mycoses of a pilar part of the head are observed preferential at children. Onychomycoses Duration of a course of treatment drug at most of patients makes 6-12 weeks. At an onychomycosis of brushes in most cases makes 6 weeks, and at an onychomycosis of feet - 12 weeks. More prolonged treatment can be required by some patients who have the reduced growth rate of nails. The optimum clinical effect is observed several months later after mycologic treatment and the termination of therapy. It is defined by that span which is necessary for growth of a healthy nail. Use of drug for children to Children drug is appointed since two years. The dose depends on the body weight of the child and makes: for children with body weight to 20 kg - 62,5 mg/days (1/4 tablets) from 20 kg to 40 kg - 125 mg/days (1/2 tablets) of more than 40 kg - 250 mg/days (1 tablet). Data on use of drug for children under two years (with body weight less than 12 kg) are not available.

Side effects:

Фунготербин® in general it is transferred well. Side effects are usually expressed poorly or moderately and have passing character. At intake can be observed:

From digestive tract: dyspepsia, abdominal pains, feeling of overflow of a stomach, nausea, appetite loss, diarrhea; sometimes disturbance of flavoring feelings, including their loss (it is recovered in several weeks after the treatment termination).

From a musculoskeletal system: muscle pains, joint pains.

From system of a hemopoiesis: a neutropenia, an agranulocytosis, thrombocytopenia, it is rare – a lymphopenia. Allergic reactions: skin rash in the form of spots, blisters, it is rare – a toxic epidermal necrolysis, Stephens-Johnson's syndrome, anaphylactoid reactions.

Contraindications:

Hypersensitivity to drug components.

With care - alcoholism, diseases of blood, a tumor, a metabolism disease, pathology of vessels of extremities. Children's age (up to 2 years). Pregnancy and lactation: experience of use of drug at pregnancy is limited therefore it is not necessary to apply Fungoterbin® at pregnancy. Terbinafin is allocated with breast milk therefore in need of purpose of drug it is necessary to resolve an issue of the breastfeeding termination.

Issue conditions:

According to the recipe

Packaging:

On 10 or 14 tablets in a blister strip packaging, one or two blister strip packagings together with the instruction on a medical use of drug in a cardboard pack.